2022
DOI: 10.1016/j.prrv.2020.08.005
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Does newborn screening improve early lung function in cystic fibrosis?

Abstract: Despite evidence showing an improvement in nutritional outcomes following diagnosis by newborn screening (NBS) for cystic fibrosis (CF), the impact on pulmonary outcomes has been less clear. In this review the approaches to measurement of early lung function and knowledge gained from NBS CF cohorts will be described. Studies which have compared outcomes in those diagnosed by NBS to those diagnosed following symptomatic presentation will be presented. Compiling the evidence base used to evaluate the impact of N… Show more

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Cited by 7 publications
(9 citation statements)
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“…1). At the time of presentation the mean age of children was 28 days (IQR [16][17][18][19][20][21][22][23][24][25][26].…”
Section: Newborn Screening Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…1). At the time of presentation the mean age of children was 28 days (IQR [16][17][18][19][20][21][22][23][24][25][26].…”
Section: Newborn Screening Resultsmentioning
confidence: 99%
“…A recent review of Davies et. al highlights the fact that clear pulmonary benefits for NBS screened children have not been demonstrated yet 22 . In concordance with this and similar to other studies, we did not observe a reduction in radiological pulmonary abnormalities as assessed by X-ray scoring in the NBS group in spite of an earlier introduction of inhalational and respiratory therapy strategies compared to our control group.…”
Section: Discussionmentioning
confidence: 99%
“…Известно, что ранняя диагностика МВ положительно влияет на выживаемость [23]. Однако в данном исследовании явные преимущества ранней диагностики (скрининга новорожденных) на функцию легких при МВ не были показаны [24]. Мы также не выявили влияния сроков установки диагноза на функцию легких.…”
Section: Discussionunclassified
“…Newborn CF screening is now a successful public health technique for early identification of afflicted infants, particularly in populations with high risk of CF prevalence (14). The majority of screening initiatives assess immuno-reactive trypsinogen (IRT) in dried blood spots, which must be taken within the first week of life.…”
Section: Newborn Screeningmentioning
confidence: 99%