Does Nutrition Matter in Liver Disease?

Ramos‐Tovar, Erika; Muriel, Pablo

doi:10.1016/b978-0-12-804274-8.00053-9

Cited by 3 publications

(3 citation statements)

References 147 publications

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“…In the liver, aldolase B, which is one of the three aldolase isoforms, participates in the interconversion of both fructose-1-phosphate and frutose-1,6-bisphosphate to dihydroxyacetone and glycerol-3-phosphate, which acts as a rate-limiting step for fructose metabolism in the liver (68)(69)(70)(71)(72)(73). Moreover, aldolase A and aldolase B have been linked to EMT in colon cancer, as they seem to interact with HIF-1 (74).…”

Section: Metabolism Characteristics Of Csc That Enhance Invasivenessmentioning

confidence: 99%

Colorectal Cancer Stem Cells in the Progression to Liver Metastasis

et al. 2020

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Colorectal carcinoma (CRC) is a leading cause of cancer mortality. Tumorigenesis is a dynamic process wherein cancer stem cells (CSCs) and their microenvironment promote initiation, progression, and metastasis. Metastatic colonization is an inefficient process that is very complex and is poorly understood; however, in most cases, metastatic disease is not curable, and resistance mechanisms tend to develop against conventional treatments. An understanding of the underlying mechanisms and factors that contribute to the development of metastasis in CRC can aid in the search for specific therapeutic targets for improving standard treatments. In this review, we summarize current knowledge regarding tumor biology and the use of stroma cells as prognostic factors and inflammatory inducers associated with the use of tumor microenvironments as a promoter of cancer metastasis. Moreover, we look into the importance of CSC, pericytes, and circulating tumor cells as mechanisms that lead to liver metastasis, and we also focus on the cellular and molecular pathways that modulate and regulate epithelial-mesenchymal transition. Finally, we discuss a novel therapeutic target that can potentially eliminate CSCs as a CRC treatment.

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Section: Metabolism Characteristics Of Csc That Enhance Invasivenessmentioning

confidence: 99%

Colorectal Cancer Stem Cells in the Progression to Liver Metastasis

et al. 2020

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“…Chronic degenerative diseases have gained high prevalence in the world as sedentarism, alcohol and tobacco consumption, improper nutritional habits, and obesity have become more common [10]. Diseases like metabolic syndrome, diabetes, and fatty liver, target many organs such as the heart, the guts, and the liver, which, when untreated can become more susceptible to develop unwanted comorbidities [8,9]. Here, there is an interesting case to be made for the liver, as not only these behaviors lead to an increase in degenerative diseases which end up affecting the liver, but also the pharmacological reagents used to treat these diseases are typically processed in the liver, hence, the combined effect becomes a disastrous scenario [3,12].…”

Section: Non-communicable Diseasesmentioning

confidence: 99%

“…Unfortunately, they include either high cholesterol or high-sugar foods including bread, starches, cold cuts, and sugary beverages, which are overall not good for the liver [5]. Also, much of the population's work schedule relates to long hours and high-levels of stress, and not to mention the rise in the cost of living under the stress of the COVID-19 pandemic [6][7][8]. Under these conditions' malnutrition, alcohol (or substance) consumption, and inadequate eating schedules are common.…”

Section: Introductionmentioning

confidence: 99%

A molecular outlook review on how coffee and oats can help redefine the way we take care of our health

Delgado-Gallegos¹,

Garza-Juarez²,

G-Buentello³

et al. 2021

TheGMS

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Chronic degenerative diseases like obesity, metabolic syndrome, diabetes, fatty liver, have gained high prevalence in the world, due to sedentarism, improper nutritional habits as well as alcohol and tobacco consumption. Studies have shown that regular consumption of breakfast leads to a wide range of benefits, especially for the liver. The liver is a key organ for metabolic homeostasis regulating and governing energy metabolism, mostly providing nutrients for reabsorption. Benefits of a nutrimental quality breakfast seem to help lower body mass index, prevent metabolic diseases, and overall improve quality of life. Unfortunately, these include either high cholesterol or high-sugar foods including cold cuts, bread, eggs, and sugary beverages. Also, much of the population’s work schedule relates to long hours and high-level of stress, therefore malnutrition, and inadequate eating schedules are common.

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Free radicals, antioxidants, nuclear factor‐E2‐related factor‐2 and liver damage

Ramos‐Tovar

Muriel

2019

J of Applied Toxicology

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Oxidative/nitrosative stress is proposed to be a critical factor in various diseases, including liver pathologies. Antioxidants derived from medicinal plants have been studied extensively and are relevant to many illnesses, including liver diseases. Several hepatic disorders, such as viral hepatitis and alcoholic or nonalcoholic steatohepatitis, involve free radicals/oxidative stress as agents that cause or at least exacerbate liver injury, which can result in chronic liver diseases, such as liver fibrosis, cirrhosis and end‐stage hepatocellular carcinoma. In this scenario, nuclear factor‐E2‐related factor‐2 (Nrf2) appears to be an essential factor to counteract or attenuate oxidative or nitrosative stress in hepatic cells. In fact, a growing body of evidence indicates that Nrf2 plays complex and multicellular roles in hepatic inflammation, fibrosis, hepatocarcinogenesis and regeneration via the induction of its target genes. Inflammation is the most common feature of chronic liver diseases, triggering fibrosis, cirrhosis and hepatocellular carcinoma. Increasing evidence indicates that Nrf2 counteracts the proinflammatory process by modulating the recruitment of inflammatory cells and inducing the endogenous antioxidant response of the cell. In this review, the interactions between antioxidant and inflammatory molecular pathways are analyzed.

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Does Nutrition Matter in Liver Disease?

Cited by 3 publications

References 147 publications

Colorectal Cancer Stem Cells in the Progression to Liver Metastasis

Colorectal Cancer Stem Cells in the Progression to Liver Metastasis

A molecular outlook review on how coffee and oats can help redefine the way we take care of our health

Free radicals, antioxidants, nuclear factor‐E2‐related factor‐2 and liver damage

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