Does omeprazole (Prilosec) improve respiratory function in asthmatics with gastroesophageal reflux?

Meier, John H.; McNally, Peter R.; Punja, Madhukar; Freeman, Scott R.; Sudduth, Robert H.; Stocker, Nancy; Perry, Michael E.; Spaulding, Harry

doi:10.1007/bf02090360

Cited by 144 publications

(72 citation statements)

References 24 publications

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“…Recently, PPI has been also used for the diagnosis of gastroesophageal reflux, not only in the patients with non-erosive reflux disease (NERD) [28,29] , but also in patients with atypical gastroesophageal reflux symptoms [30,31] . The present study suggests that the four kinds of PPI are effective for the diagnosis of the existence of gastroesophageal acid reflux, and it may be worthwhile investigating whether esomeprazole can shorten the time period necessary for diagnosis.…”

Section: A L T H O U G H T H E S Y M P T O M R E L I E F Wa S F a S Tmentioning

confidence: 99%

Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis

Zheng¹

2009

WJG

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AIM:To clarify whether there is any difference in the symptom relief in patients with reflux esophagitis following the administration of four Proton pump inhibitors (PPIs). METHODS:Two hundred and seventy-four patients with erosive reflux esophagitis were randomized to receive 8 wk of 20 mg omeprazole (n = 68), 30 mg of lansoprazole (n = 69), 40 mg of pantoprazole (n = 69), 40 mg of esomeprazole (n = 68) once a day in the morning. Daily changes in heartburn and acid reflux symptoms in the first 7 d of administration were assessed using a six-point scale (0: none; 1: mild; 2: mild-moderate; 3: moderate; 4: moderate-severe; 5: severe). RESULTS:The mean heartburn score in patients treated with esomeprazole more rapidly decreased than those receiving other PPI. Complete resolution of heartburn was also more rapid in patients treated with esomeprazole for 5 d compared with omeprazole (P = 0.0018, P = 0.0098, P = 0.0027, P = 0.0137, P = 0.0069, respectively), lansoprazole (P = 0.0020, P = 0.0046, P = 0.0037, P = 0.0016, P = 0.0076, respectively), and pantoprazole (P = 0.0006, P = 0.0005, P = 0.0009, P = 0.0031, P = 0.0119, respectively). There were no significant differences between the four groups in the rate of endoscopic healing of reflux esophagitis at week 8. CONCLUSION:Esomeprazole may be more effective than omeprazole, lansoprazole, and pantoprazole for the rapid relief of heartburn symptoms and acid reflux symptoms in patients with reflux esophagitis.

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Section: A L T H O U G H T H E S Y M P T O M R E L I E F Wa S F a S Tmentioning

confidence: 99%

Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis

Zheng¹

2009

WJG

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“…Asthma symptoms also correlated with esophageal pH events on 24-h esophageal pH monitoring [11] . Previous studies on the effect of antireflux therapy on asthma have shown inconsistent results [12][13][14][15][16][17][18][19][20][21][22][23][24] . Most of these studies have been done in small groups of patients with different proton-pump inhibitors and were done for short durations of anti-reflux therapy.…”

Section: Introductionmentioning

confidence: 99%

Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux

Sharma

Sharma²,

Daga³

et al. 2007

WJG

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AIM:To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesophageal reflux. METHODS:We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and after 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symptom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbronchodilator forced expiratory volume in 1 second (FEV1) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS:Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9%), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antireflux therapy compared to mean change in placebo group (P < 0.001). There was significant improvement in morning PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEV1 (11.1% vs 3.78%) and FVC (9.3% vs 1.52%) in the antireflux therapy group compared to placebo on comparing the mean change from baseline after 16 wk (P < 0.01). CONCLUSION:Combined therapy with Ome and Dom in adult asthmatics with gastroesophageal reflux may be beneficial by reducing asthma symptoms, rescuing medication use, and improving pulmonary function.

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“…There have been many studies dealing with asthma outcome and medical anti-reflux therapy. Field and Sutherland (1998) reviewed the previously published data on medical anti-reflux therapy with H 2 -receptor blockers (H 2 blockers), cimetidine (Goodall et al 1981;Larrain et al 1991) and ranitidine (Harper et al 1987;Nagel et al 1988;Ekstrom et al 1989;Gustaffson et al 1992), and with a proton pump inhibitor (PPI) omeprazole (Ford et al 1994;Meier et al 1994;Harding et al 1996;Teichtahl et al 1996), showing that asthma symptoms were improved. Kiljander (2003) suggested that, in the management of GERD-related asthma, PPIs other than omeprazole should be used at double the standard dose.…”

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confidence: 99%

A Proton Pump Inhibitor, Lansoprazole, Ameliorates Asthma Symptoms in Asthmatic Patients with Gastroesophageal Reflux Disease

Shimizu

Dobashi

Kobayashi³

et al. 2006

Tohoku J. Exp. Med.

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Aspiration of acid to the airway causes airway inflammation, and acid stress to the airway caused by gastroesophageal reflux disease (GERD) has been known as a potential mechanism of deteriorated asthma symptoms. However, the efficacy of the acid suppressive drugs, H 2 -receptor blockers (H 2 blocker) and proton pump inhibitors, on asthma symptoms and pulmonary functions remains controversial. We therefore designed the randomized prospective study to determine the efficacy of an H 2 blocker (roxatidine, 150 mg/day) and a proton pump inhibitor (lansoprazole, 30 mg/day) on asthma symptoms of 30 asthmatic patients with GERD. These patients were divided in the two groups (15 patients for each group) and treated with either roxatidine or lansoprazole. The diagnosis of GERD was established by the method of Los Angeles classification including mucosal minimum change of Grade M and questionnaire for the diagnosis of reflux disease (QUEST) score. The efficacy of acid suppressive drugs was evaluated by peak expiratory flow (PEF), asthma control questionnaire (ACQ) that evaluates the improvement of asthma symptoms, and forced expiratory volume in 1 second (FEV 1.0 ). Lansoprazole, but not roxatidine, significantly improved PEF and ACQ scores ( p < 0.05) with the improved QUEST scores. However, these acid suppressive drugs did not change the pulmonary function of FEV 1.0 in asthmatic patients. In conclusion, treatment with a proton pump inhibitor, lansoprazole, appears to be useful in improvement of asthma symptoms in asthmatic patients with GERD.asthma; gastroesophageal reflux disease; proton pump inhibitor; H 2 -receptor blocker

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Does omeprazole (Prilosec) improve respiratory function in asthmatics with gastroesophageal reflux?

Cited by 144 publications

References 24 publications

Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis

Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis

Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux

A Proton Pump Inhibitor, Lansoprazole, Ameliorates Asthma Symptoms in Asthmatic Patients with Gastroesophageal Reflux Disease

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