Does Pregnancy Contribute to Systemic Right Ventricular Dysfunction in Adults with an Atrial Switch Operation?

Pregnancy and long-term cardiovascular outcomes in women with congenitally corrected transposition of the great arteries

“…The present study did not show that pregnancy contributed to systemic right ventricular failure in women with ccTGA, and the data on long‐term adverse effects of pregnancy on systemic RV remain inconsistent. Zentner et al [17] observed a significantly higher rate of heart failure prescriptions in the pregnancy group among women with d‐TGA who had undergone atrial switch operations. Another study of patients with systemic RV (including 4 women with ccTGA) showed a significant but similar degree of deterioration in right ventricular function in pregnant women and male and non‐pregnant female controls at latest follow‐up [18].…”

Cardiac function and cardiac events 1-year postpartum in women with congenital heart disease

“…Data from a small number of (mostly retrospective) studies have suggested that pregnancy may have an adverse effect on maternal cardiac outcome (with each subsequent pregnancy causing progression of cardiac dysfunction) and that women with adverse cardiac events during pregnancy are at increased risk for cardiac events N6 months after pregnancy. [5][6][7][8][9][10][11][12] Prospective research data are very limited and concern only small study populations.…”

Pregnancy outcomes and mid-term prognosis in women after arterial switch operation for dextro-transposition of the great arteries – Tertiary hospital experiences and review of literature

“…Some cases of the atrial switch group had not recovered from systemic ventricular dysfunction at the mid-term follow-up after delivery. Moreover, six women in seven reports of the atrial switch group showed more severe cardiac complications, such as maternal death or CPA during pregnancy and at the mid-term follow-up after delivery, while no maternal death has been reported among arterial case [2][3][4]13].…”

“…The eight articles were classified as describing pregnancy outcomes after atrial switch operation (seven reports) and outcomes after ASO (one report) ( Fig. 1) [2][3][4]13,[15][16][17][18]. A total of 8 articles and this study were reviewed.…”

“…However, the past studies have described that these patients were at high risk of systemic right ventricular dysfunction, atrial arrhythmias, and cardiac death at long-term follow-up [1]. Pregnancy with d-TGA after atrial switch operation resulted in severe cardiac complications such as maternal death or cardiopulmonary arrest (CPA) during pregnancy and by mid-term follow-up after delivery [2][3][4].…”