Does Radial Artery Pressure Accurately Reflect Aortic Pressure?

Pauca, Alfredo L.; Wallenhaupt, Stephen L.; Kon, Neal D.; Tucker, William Y.

doi:10.1378/chest.102.4.1193

Cited by 310 publications

(200 citation statements)

References 18 publications

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“…One previous study 1 has shown that SBP in the radial artery was higher by more than 10 mmHg than SBP in the ascending aorta. Elucidation of the clinical parameters correlated with peripheral-central SBP difference is potentially important, as central SBP would be expected to be a more sensitive marker than peripheral SBP for cardiovascular risk stratification.…”

Section: Dear Sirmentioning

confidence: 87%

Estimation of aortic systolic blood pressure in community-based screening: the relationship between clinical characteristics and peripheral to central blood pressure differences

2004

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Section: Dear Sirmentioning

confidence: 87%

Estimation of aortic systolic blood pressure in community-based screening: the relationship between clinical characteristics and peripheral to central blood pressure differences

2004

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“…[8][9][10] Although SBP and PP are known to increase physiologically and significantly (8-12 mm Hg) from central to peripheral arteries, falls in DBP or MBP from the ascending aorta to the radial artery do not exceed 2-3 mm Hg. [9][10][11] Therefore, the carotid pressure wave was calibrated assuming that radial and carotid DBP and MBP were nearly equal. The MBP of the carotid pressure wave, computed from the area measurement of the wave in the corresponding heart period, was taken as equal to brachial MBP.…”

Section: Brachial and Carotid Bp And Hr Measurementsmentioning

confidence: 99%

Cardiovascular prevention: relationships between arterial aging and chronic drug treatment

Lieber

Millasseau²,

Mahmud

et al. 2011

J Hum Hypertens

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Drugs acting on cardiovascular (CV) prevention are, by definition, interconnected with age-induced arterial changes. However, this question has been poorly investigated along long-term treatment. This goal requires a major prerequisite: to determine statistical links associating age-induced changes in arterial stiffness and wave reflections with drug classes acting on CV prevention. We studied 347 subjects where CV prevention involved hypertension, diabetes mellitus and hypercholesterolaemia; and included six drug classes: diuretics, b-blocking agents, angiotensin II (ANGII) and calcium-channel (CCB) blockers, insulin therapy and statins. For each class, the total population was divided into two subgroups according to the presence or absence of the corresponding class. Statistical comparisons between subgroups involved brachial and central blood pressure measurements, aortic pulse wave velocity (PWV), augmentation index (AIx), used as a marker of wave reflections. Non-invasive measurements included tonometry and pulse wave analysis. Appropriate adjustments indicated among results the respective role of age, sex, mean blood pressure (MBP), standard risk factors and other confounding variables. CCB and statins did not exhibit statistical association with PWV or AIx. b-Blocking agents were significantly linked with heart rate reduction and resulting increase in AIx and central pulse pressure (PP). Increased PWV independent of age, MBP, CV risk factors were noticed under diuretics, ANGII blockers and insulin, pointing to intrinsic modifications of the arterial wall. Treatment of CV prevention involves alterations of the arterial wall depending on drug class. b-Blocking agents and insulin are associated with the higher increases of central PP.

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“…26 Due to differences in vessel compliance and wave reflection, the shape of the arterial waveform, 27,28 and systolic blood pressure in particular, varies throughout the arterial tree. 29 Peripheral pulse pressure is higher than brachial artery pressure in most individuals -ie, there is amplification moving away from the aorta. 29 However, with age, central pulse pressure rises and the amplification ratio falls, 14 and similar changes might be expected with other conditions, that induce premature vascular stiffening such as hypertension, diabetes mellitus and cigarette smoking.…”

Section: Pulse Wave Analysismentioning

confidence: 99%

“…29 Peripheral pulse pressure is higher than brachial artery pressure in most individuals -ie, there is amplification moving away from the aorta. 29 However, with age, central pulse pressure rises and the amplification ratio falls, 14 and similar changes might be expected with other conditions, that induce premature vascular stiffening such as hypertension, diabetes mellitus and cigarette smoking. Therefore, simply measuring peripheral pulse pressure will not provide a reliable estimate of central haemodynamics.…”

Section: Pulse Wave Analysismentioning

confidence: 99%