Objective. Breast milk is the best food for newly born infants because it is more digestible and can relieve infants’ gastrointestinal burdens. The purpose of this study was to investigate the application effect of abdominal acupoint massage on feeding intolerance in premature infants. Methods. A total of 50 premature infants with feeding intolerance admitted to our hospital from January 2018 to October 2019 were selected and randomly divided into the control group (n = 25) and the experimental group (n = 25). Among them, the premature infants in the control group received routine therapy, while based on the treatment in the control group, the premature infants in the experimental group were treated with abdominal acupoint massage. After that, the incidence of feeding intolerance, MNA nutritional status score, body mass, development state, length of hospital stay, and response rate were all compared between the two groups to analyze the application effect of abdominal acupoint massage on feeding intolerance in premature infants. Results. The incidence of feeding intolerance of the premature infants in the experimental group was significantly lower than that in the control group, with statistically significant differences (
P
<
0.05
); the MNA nutritional status scores of the premature infants in the experimental group were significantly higher than those in the control group, with statistically significant differences (
P
<
0.05
); the body mass and development state of the premature infants in the experimental group were significantly better than those in the control group, with statistically significant differences (
P
<
0.05
); the length of hospital stay of the premature infants in the experimental group was significantly shorter than that in the control group, with statistically significant differences (
P
<
0.05
); the response rate in the experimental group was significantly higher than that in the control group, with statistically significant differences (
P
<
0.05
). Conclusions. Abdominal acupoint massage therapy can significantly reduce the incidence of feeding intolerance, shorten the length of hospital stay, and improve nutritional status, development state, and response rate in premature infants, with obvious therapeutic effect, which is worthy of application and promotion in clinical practice.