Does sickle cell disease have a psychosomatic component? A particular focus on anxiety and depression

Toumi, M; Merzoug, Sameha; Boulassel, Mohamed Rachid

doi:10.1016/j.lfs.2018.08.066

Cited by 19 publications

(9 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Under hypoxic circumstances, usually disc-shaped red blood cells become sickle-shaped, non-deformable, and poorly capable of passing through the small vessels, thus leading to ischemia presented with acute pain and, finally, organ dysfunction [ 4 ]. These physical changes have a negative impact on the quality of life (QoL) of SCD patients [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

Al-Marzouki¹,

Alrefaie²,

Aljohani³

et al. 2021

Cureus

View full text Add to dashboard Cite

Background Sickle cell disease (SCD) is a recessive hereditary condition. The physical changes caused by SCD affect the quality of life (QoL) by negatively impacting psychological aspects. Objective This study aimed to assess the prevalence of depression and anxiety in SCD patients based on different sociodemographic characteristics in Jeddah, Saudi Arabia. Method A cross-sectional study was conducted at King Abdulaziz University Hospital (KAUH) in Jeddah from 13 July to 30 August 2021. The included patients were 18 years of age and above and affected with sickle cell disease. Medical staff interviewed the patients and filled the Patient Health Questionnaire (PHQ)-9 and General Anxiety Disorder (GAD)-7. Result One hundred nineteen (119) patients were included in this study. The median age of participants was 32 and mostly male (n=72, 60.5%). The rate of depression was 45.4%. On the other hand, the rate of anxiety was 22.7%. The median of the PHQ-9 score was 8±8 while the median of the GAD-7 score was 5±8. Moreover, the study showed that anxiety and depression in relation to sociodemographics were higher in the patient age groups of 30-34 years old, male, single, unemployed, and with higher education. There was a significant association between depression rate and the two variables: patient employment status (49.3%; p=0.047) and a family history of SCD (51%). Conclusion Depression in patients with sickle cell disease is prevalent and correlated to demographic and social factors.

show abstract

Section: Introductionmentioning

confidence: 99%

The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

Al-Marzouki¹,

Alrefaie²,

Aljohani³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…These physical changes in the body become the cause of psychological disorders and depression, and anxiety are the most common among them. These psychosocial disorders have a negative impact on quality of life (QoL) to the patients 2. The World Health Organization (WHO) reported that depression affects over 154 million individuals globally 3…”

mentioning

confidence: 99%

Systematic psychiatric assessment of patients with sickle cell disease

Zahrani

Mukhtar

Subaie

et al. 2019

SMJ

View full text Add to dashboard Cite

Objectives: To determine the level of the psychological problems such as depression and anxiety in sickle cell disease (SCD) patients in Tabuk region, northwestern Saudi Arabia. Methods: In this cross-sectional study, 89 patients with SCD was assessed in the outpatient clinics of King Salman Armed Forces Hospital, Tabuk, Saudi Arabia between March 2017 and August 2017. Two validated Arabic translated questionnaires, the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7), were used to assess the type and degree of psychopathology (anxiety or depression) each patient suffered. Chi-square test was used to assess the differences between anxiety and depression levels according to the different sociodemographic characteristics of the participants. Results: The values were computed by analyzing the Cronbach’s alphas for the GAD-7 (0.83) and PHQ-9 (0.81) questionnaires. The rate of depression was 36% and anxiety was 29%. Female patients with SCD reported a higher incidence of depression and anxiety than males ( p >0.05). Patients with a higher level of education were significantly more anxious about their illness than those with a lower level education ( p =0.02). Conclusion: A statistically insignificant association was reported between depression and anxiety with regard to gender; however, female patients reported a higher incidence of depression and anxiety than male patients. A significant association with anxiety was reported among patients with higher levels of education.

show abstract

“…We cannot deduce from these results the percentage of patients suffering from psychological disorders. In other studies, the proportion of SCD patients reporting psychological disturbances was very variable: 18 to 62% for depressive symptoms and 7 to 67% for anxiety symptoms [26,[49][50][51][52].…”

Section: Medication and Psychoactive Substances Usementioning

confidence: 77%

Descriptive analysis of sickle cell patients living in France: The PHEDRE cross-sectional study

et al. 2021

View full text Add to dashboard Cite

Background Sickle cell disease (SCD) induces chronic haemolytic anaemia and intermittent vaso-occlusion that results in tissue ischaemia causing acute, severe pain episodes that can lead to frequent hospitalizations. These consequences can have repercussions on family, social, school and/or professional life. Here, we present some of the results of the PHEDRE study (Pharmacodépendance Et DREpanocytose—drug dependence and sickle-cell disease), which is the largest study of patients with SCD in France. This paper intends to describe characteristics of the French SCD population. We also aimed to assess the impact of the disease on the lives of patients using objective and subjective variables. Methods The PHEDRE study was a national multicentric observational study. Adults, adolescents and children with a confirmed SCD diagnosis were included in the study by their referring doctor. Then, they were interviewed by phone about their socioeconomic status, about the impact of the disease on their lives and about their analgesic and psychoactive drug use. Results The study population consisted of 872 patients (28% were minors). Seventy-two percent of adults were active, and all minors were in school. Many patients presented criteria of severe SCD. Seventy-five percent were homozygous SS, 15% were double heterozygotes SC and 8% were heterozygotes Sβthal, 87% received specific treatment, 58% were hospitalized at least once for vaso-occlusive crisis in the past 12 months, and the number of analgesic drugs taken averaged 3.8. Seventy-five percent of patients reported academic or professional consequences related to their SCD, and 52% reported social consequences. Conclusions The impact of SCD on patients’ lives can be significant, nevertheless their social integration seems to be maintained. We highlighted respect of recommendations regarding analgesic treatments and only a few patients used tobacco, alcohol or cannabis. Trial registration Clinical Trials, NCT02580565; https://clinicaltrials.gov/ Registered 16 October 2015.

show abstract

Does sickle cell disease have a psychosomatic component? A particular focus on anxiety and depression

Cited by 19 publications

References 49 publications

The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

Systematic psychiatric assessment of patients with sickle cell disease

Descriptive analysis of sickle cell patients living in France: The PHEDRE cross-sectional study

Contact Info

Product

Resources

About