Measuring and explaining sociospatial segregation is essential in urban and social geography. Recent advances in activity space-based segregation provide new opportunities to study sociospatial segregation. This paper provides a comprehensive review of the emerging activity space-based segregation research in terms of measurements, dimensions, and influential factors. We highlight the trend toward integrating spatial, temporal, and social dimensions in activity space-based segregation measurement. Then, a multidimensional framework is constructed to cover the spatial form, opportunity exposure, spatiotemporal interaction, and social relationship of activity space-based segregation research. This paper ends with challenges and future directions for activity space-based segregation research, highlighting the importance of the temporal dimension, social interaction, influential mechanisms, and social effects.