Does sphincter of oddi dysfunction cause chronic pancreatitis?

Tarnasky, I.; Knapple, Whitfield L.; Coyle, W; Pineau, Benoit C.; Brooker, C; Hoffman, Brenda J.; Aabakken, Lars; Cunningham, J; Cotton, Peter B.; Hawes, Robert H.

doi:10.1016/s0016-5107(96)80429-9

Cited by 17 publications

(22 citation statements)

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“…This is remarkable because pancreatobiliary drainage by endoscopic placement of an endoprothesis (needing exchange of stents at intervals of 2 to 4 mo) is accompanied with complications and shows poor long-term results [15,16] . Since papillary stenosis has been suggested to play a possible role as a pathogenetic factor in pancreatitis [6,17,18] , the present study included patients with pancreatitis type symptoms and focused on changes in exocrine pancreatic function. Therapeutical approaches in patients with chronic pancreatitis aim to alleviate pain, prevent attacks of pancreatitis, reduce the effects of pancreatic insufficiency and manage complications no matter what the etiology of chronic pancreatitis might be.…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater: Three-year follow-up of exocrine pancreatic function and clinical symptoms

Ewald¹

2007

WJG

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AIM: To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS:After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type Ⅰ), followup examinations were performed in 60 patients (mean follow-up time 37.7 mo). Patients were asked about clinical signs and symptoms at present and before intervention using a standard questionnaire. Before and after ES exocrine pancreatic function was assessed by determination of immunoreactive fecal elastase 1. Serum enzymes indicating cholestasis as well as serum lipase and amylase were measured. RESULTS:Eighty percent of patients reported an improvement in their general condition after ES. The fecal elastase 1 concentrations (FEC) in all patients increased significantly after ES. This effect was even more marked in patients with pathologically low concentrations (< 200 μg/g) of fecal elastase prior to ES. The levels of serum lipase and amylase as well as serum alcaline phosphatase (AP) and gamma-glutamyltranspeptidase (GGT) decreased significantly after ES. CONCLUSION:The results of this study demonstrate that patients with stenosis of the ampulla of Vater can be successfully treated with endoscopic sphincterotomy. The positive effect is not only indicated by sustained improvement of clinical symptoms and cholestasis but also by improvement of exocrine pancreatic function.© 2007 The WJG Press. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

“…Gallstones, bile duct microlithiasis and sludge may repeatedly induce ductal lesions leading to obstruction and stenosis of the papilla of Vater [5][6][7] . In addition to the resulting problems concerning the bile duct system, chronic obstruction of the papilla of Vater may also contribute to lesions of the pancreas.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater: Three-year follow-up of exocrine pancreatic function and clinical symptoms

Ewald¹

2007

WJG

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“…Occasionally pathology at the minor papilla such as pancreatic divisum, can be a cause of chronic pancreatitis (Tarnasky et al, 1997). Minor papillotomy, dividing only the mucosal mound rather than true sphincterotomy, can be performed to achieve decompression of the dorsal duct (Buscaglia & Kalloo, 2007).…”

Section: Endoscopic Sphincterotomymentioning

confidence: 99%

Endoscopic Treatment in Chronic Pancreatitis

Cheung¹,

Lai²

2012

Chronic Pancreatitis

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“…It has been shown that local installation of alcohol on the SO results in elevated SO pressures, suggesting a role in the pathogenesis of alcoholic pancreatitis [65] . Tarnasky et al [66] looked for evidence of chronic pancreatitis in patients undergoing manometry for investigation of unexplained upper abdominal pain (n = 104). Pancreatic ductography, EUS and pancreatic fluid bicarbonate concentration measurements were carried out.…”

Section: Sod and Chronic Pancreatitismentioning

confidence: 99%