Does sublingual misoprostol reduce pain and facilitate IUD insertion in women with no previous vaginal delivery? A randomized controlled trial

Role of vaginal misoprostol prior to levonorgestrel-releasing IUD insertion

“…In accordance with our findings, A research group in AL Azhar university stated that using vaginal misoprostol before IUD insertion in parous women who had previously failed insertion enhanced the rate of successful insertion, especially in women who had previously caesarean delivery 20 . However, in their work, they used the copper IUD.…”

Does the cervical canal passage axis have an effect on pain sensation in IUD application?: a randomized controlled trial

“…Mansy et al (18) studied 200 mg misoprostol administered patients who had undergone IUD and the placebo group; no statistically significant difference was observed between the groups in terms of pain. Similar results were obtained in the study performed by İbrahim et al (19) due to the side effects of misoprostol, and this drug is not recommended to be used before IUD insertion.…”

Sublingual misoprostol prior to intra uterine contraceptive device insertion in women with previous cesarean section who had never delivered vaginally

“…14 However, other studies showed no improvement in discomfort during the operation or an increase in the probability of a successful insertion. 15 Dijkhuizen et al, 2014 performed a 270-patient RCT to see whether pretreatment with vaginal misoprostol makes it easier to implant an IUD in nulliparous and multiparous women. They found no advantage to using misoprostol before IUD pullout.…”