Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

Binard, Aymeric; Saraux, Alain; Devauchelle‐Pensec, Valérie; Pers, Jacques‐Olivier; Youinou, Pierre

doi:10.1016/j.jaut.2007.11.001

Cited by 30 publications

(12 citation statements)

References 58 publications

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“…This result itself is not surprising considering the relationships of inflammatory mediators in a variety of human and autoimmune murine diseases [40][41][42][43]. Indeed, that is the basis for targeted therapies [44].…”

Section: Discussionmentioning

confidence: 83%

Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis

Barak

Selmi

Schlesinger

et al. 2009

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 83%

Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis

Barak

Selmi

Schlesinger

et al. 2009

Journal of Autoimmunity

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“…Table 2 summarize characteristics that distinguishes between TaCD3 CD4+CD25 Treg, Tr-1 and Th3 cells. We note that this manuscript is part of a special series of papers on the mosaic of autoimmunity (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). Figure 1.…”

Section: Discussionmentioning

confidence: 99%

In vitro induction of regulatory T cells by anti-CD3 antibody in humans

Abraham

Karni

Dembinsky

et al. 2008

Journal of Autoimmunity

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Therapy with anti-CD3 antibody is effective in controlling models of autoimmune diseases and can reverse or prevent rejection of grafts. We studied the in vitro immunomodulatory effect of anti-CD3 treated human T cells. CD4 + T cells were stimulated with plate bound anti-CD3 and cultured for 12 days after which they were cultured with autologous peripheral blood mononuclear cells (PBMCs) and stimulated with soluble anti-CD3. We found that CD4 + T cells that were stimulated with anti-CD3 (T αCD3 ) markedly suppressed the proliferation and cytokine production of autologous PBMCs. These regulatory T cells were not induced by incubation with isotype control (T Control ) antibody or when anti-CD3 was combined with high doses of anti-CD28 (T αCD3/CD28 ). T αCD3 regulatory cells were anergic and produced lower levels of IFN-γ, TNF-α and IL-2, and higher levels of TGF-β than T Control or T αCD3/CD28 .There were no differences in the expression of CD25, CD45RB or CTLA-4 on T αCD3 as compared to T Control or T αCD3/CD28 and CD4 + CD25 − T αCD3 cells were identical to CD4 + CD25 + T αCD3 cells in their in vitro suppressive properties. Recombinant IL-2 in vitro abrogated the suppressive effect of T αCD3 . The suppressive effect was not related to apoptosis, was independent of HLA since T αCD3 also suppressed allogeneic PBMCs, and was not related to soluble factors. Finally, no suppression was observed when non T cells were removed from culture or when cultures were stimulated with plate bound anti-CD3, consistent with the ability of T αCD3 to downregulate CD80 on dendritic cells in co-culture experiments. Thus, we have identified human T cells with strong in vitro regulatory properties induced in vitro by anti-CD3 which appear to act in a non-HLA restricted fashion by affecting antigen presenting cells.

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“…BAFF acts synergistically with IL-6 and IL-21 to foster survival and differentiation of B cells in humans. It is synthesized by monocytes, neutrophils, DCs, and T cells [128, 129]. …”

Section: Pathogenesis and Antibodiesmentioning

confidence: 99%

Lupus Nephritis: An Overview of Recent Findings

Salgado

Herrera-Diaz

2012

Autoimmune Diseases

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Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a result of an amplified epitope immunological response. IC glomerular deposits generate release of proinflammatory cytokines and cell adhesion molecules causing inflammation. This leads to monocytes and polymorphonuclear cells chemotaxis. Subsequent release of proteases generates endothelial injury and mesangial proliferation. Presence of ICs promotes adaptive immune response and causes dendritic cells to release type I interferon. This induces maturation and activation of infiltrating T cells, and amplification of Th2, Th1 and Th17 lymphocytes. Each of them, amplify B cells and activates macrophages to release more proinflammatory molecules, generating effector cells that cannot be modulated promoting kidney epithelial proliferation and fibrosis. Herein immunopathological findings of LN are reviewed.

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Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

Cited by 30 publications

References 58 publications

Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis

Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis

In vitro induction of regulatory T cells by anti-CD3 antibody in humans

Lupus Nephritis: An Overview of Recent Findings

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