Does the genetic and familial background of males undertaking ICSI affect the outcome?

Maiburg, Merel C.; Alizadeh, Behrooz Z.; Kastrop, P.M.M.; Lock, M.T.W.T.; Lans, Sjors P. A. van der; Giltay, Jacques C.

doi:10.1007/s10815-009-9315-9

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…As chromosome abnormalities are a known cause of infertility, some differences regarding success rate might be expected between groups. However, studies reporting success rates of ICSI among couples with chromosomal abnormalities also found no significant differences from a control group [23,24]. This might be explained by the fact that ovarian stimulation, required to perform any ART technique, may extend the process of natural selection thus increasing the rejection of abnormal oocytes and the probability of producing a normal embryo [25].…”

Section: Discussionmentioning

confidence: 99%

Reproductive success of assisted reproductive technology in couples with chromosomal abnormalities

Jesus

Silva-Soares

Silva

et al. 2019

J Assist Reprod Genet

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Purpose Infertility is estimated to affect 15% of couples, having chromosome abnormalities an important role in its etiology. The main objective of this work was to access the reproductive success of ART in infertile couples with chromosomal abnormalities comparing to a control group with normal karyotype. Methods A 7-year retrospective karyotype analysis of infertile couples was done. Data regarding type of infertility, couples' ages, ART performed, and their reproductive success were obtained. Adjusted odds ratio (OR) were used to estimate magnitude of association between the reproductive success and the different groups. Results We found a prevalence of 7.83% of chromosome abnormalities in our population (233 couples out of 2989). Chromosomal anomalies were found in 82 men (34.75%) and 154 women (65.25%), with low-grade mosaicism being the most prevalent (50.85%), followed by autosomal translocations (17.37%) and sex chromosomes abnormalities (13.56%). Only 2359 couples were treated with ART. There was a non-significant lower reproductive success rate in the cases (OR = 0.899, p = 0.530) with IVF providing the higher success rate. In general, female carriers of chromosome anomalies had a higher success rate, although not significant. Conclusion Although the differences regarding success rate between groups were not found statistically significant, we still advocate that cytogenetic analysis should be performed routinely in all infertile couples namely before ART. This might help deciding the best treatment options including Preimplantation Genetic Testing for aneuploidies or structural rearrangements and minimize the risk of transmission of anomalies to the offspring.

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Section: Discussionmentioning

confidence: 99%

Reproductive success of assisted reproductive technology in couples with chromosomal abnormalities

Jesus

Silva-Soares

Silva

et al. 2019

J Assist Reprod Genet

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“…7 ICSI, throughout the world, achieves a success rate of 25 to 30% of pregnancies. 8 It is nowadays an established and indispensable technique in assisted reproduction programs, allowing paternity even for men with very poor-quality sperm. It can be proceeded with thawed sperm or those semen with abnormal sperm concentration, motility or morphology.…”

Section: /6mentioning

confidence: 99%

Factors associated with the success of intracytoplasmic sperm injection for the treatment of conjugal infertility

Nunes¹,

Vieira²,

Traebert³

2019

Hum. Reprod. Arch.

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Objectives: Obtaining and maintaining pregnancy after intracytoplasmic sperm injection (ICSI) may be affected by many technical factors. The goal of this study is to determine the rates of success from ICSI technique with established parameters and assess the associated factors to its success to treat infertility. Methods: A cross-sectional study involving 115 infertile couples submitted to ICSI was performed to test the association between technical aspects and success rates, from July 2013 to December 2014. Data collection was done through medical records. The bivariate associations were calculated by prevalence ratios and a Poisson regression was performed with significance level p < 0.05. Results: The aspiration of eight or more oocytes was 0.73 times (CI 95% 0.57-0.94) less associated (p = 0.014), but transferring two or more embryos was 1.75 times (CI 95% 1.54-1.99) more associated with the viable pregnancy (p < 0.001). The remaining characteristics of the ICSI procedures were not significantly associated with the expected outcome. Conclusions: The prevalence of the viable pregnancy after ICSI procedure was 40.9%. This index was positively influenced by the aspiration of less than eight oocytes and the transferring of two or more embryos.

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Does the genetic and familial background of males undertaking ICSI affect the outcome?

Cited by 3 publications

References 16 publications

Reproductive success of assisted reproductive technology in couples with chromosomal abnormalities

Reproductive success of assisted reproductive technology in couples with chromosomal abnormalities

Factors associated with the success of intracytoplasmic sperm injection for the treatment of conjugal infertility

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