Does the Oral-Anal Transit Test Correlate with Colonic Manometry Findings in Children with Refractory Constipation?

Dranove, Jason E.; Fleishman, Nathan R; Reddy, S.N.; Teich, Steven

doi:10.5223/pghn.2020.23.2.137

Cited by 6 publications

(12 citation statements)

References 18 publications

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“…Study by Dranove et al (32) on 34 children showed that CTT (authors used the oral-anal transit test) is a good tool to rule out slow transit constipation, but one should plan further investigations to assess for the location of segmental dysmotility, especially if surgical treatment is considered.…”

Section: Normative Datamentioning

confidence: 99%

Colonic Function Investigations in Children

Rybak

Martinelli

Thapar

et al. 2022

J. pediatr. gastroenterol. nutr.

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Disorders of colonic motility, most often presenting as constipation, comprise one of the commonest causes of outpatient visits in pediatric gastroenterology. This review, discussed and created by the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Motility Working Group, is a practical guide, which highlights the recent advances in pediatric colonic motility testing including indications, technical principles of the tests, patient preparation, performance and basis of the results’ analysis of the tests. classical methods, such as colonic transit time (cTT) with radiopaque markers and colonic scintigraphy, as well as manometry and novel techniques, such as wireless motility capsule and electromagnetic capsule tracking systems are discussed.

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Section: Normative Datamentioning

confidence: 99%

Colonic Function Investigations in Children

Rybak

Martinelli

Thapar

et al. 2022

J. pediatr. gastroenterol. nutr.

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“…Although this test could provide directions for diagnosis and treatment, the way is not straight. And, in some patients who do not respond to conventional medical therapy or cannot taper the medicine, further studies are required to investigate the roles of outlet function, which includes the pelvic floor and puborectalis muscle, sigmoid colon, and anorectum, and slow transit, which includes the entire colon except the sigmoid colon [ 5 6 7 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most recent studies on pediatric constipation have conducted aggressive tests, such as entire colon manometry, after a simple brief study without the evaluation of anorectal outlet function [ 8 ]. However, considering the frequency of the underlying diseases, feasibility of examination, and treatment in pediatric patients, it is reasonable to evaluate outlet function before aggressive end-stage studies, such as entire colon manometry.…”

Section: Introductionmentioning

confidence: 99%

Dyssynergic Defecation in Chronically Constipated Children in Korea

Bae

2023

Pediatr Gastroenterol Hepatol Nutr

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Purpose Dyssynergic defecation (DSD) is one of the important causes of chronic constipation in children. We aimed to analyze the clinical features, diagnostic test results, and treatments for DSD in children. Methods Children diagnosed with DSD using fluoroscopic defecography were enrolled in this study. Clinical data, including the results of colon transit time (CTT) test and biofeedback (BF) therapy, were collected from medical records retrospectively. Results Nineteen children were enrolled. The median age was 9 years (6–18 years), the median frequency of bowel movement was 1/7 days (1–10 days), the median duration of constipation was 7.0 years (2–18 years), the median age of onset of constipation was 2.5 years (1–11 years). In the CTT test, outlet obstruction type was noted in 10/18 (55.6%), slow transit type in 5/18 (27.8%), and normal transit in 1/18 (5.6%). The median CTT was 52 hours (40–142 hours). Initial medical therapy was performed with the polyethylene glycol 4000, and the response was good in 9/19 (47.4%), fair in 9/19 (47.4%), and poor in 1/19 (5.0%). BF was performed in 8/19, with good results in 6/8 (75.0%) children and failure in 2/8 (25.0%) children. After long-term medical therapy (11/19), 3/5 showed good response with medication alone, 6/8 showed good response with BF and medication combined. Conclusion DSD should be considered as a cause of chronic constipation in children, especially in those with abnormal CTT test results. BF combined with medical therapy is effective even with age-limited cooperation.

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“…To our knowledge, there are only three studies that have evaluated the relationship between OTT and CM [5,10,13] outcome of the CM study. We aimed to study the correlation of OTT (SITZMARKS) with CM in a larger sample size, compare the results of OTT, ARM, and CM, and determine the outcomes of treatment changes that were made based on the results of CM.…”

Section: Introductionmentioning

confidence: 99%

Oro-Anal Transit Time and Colon Manometry: Predictability and Outcomes in Children With Functional Constipation

Shaukat,

Altaf

2023

Cureus

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Objectives: The primary objective of the study was to evaluate the correlation of oro-anal transit time (OTT) using SITZMARKS® (Konsyl Pharmaceuticals Inc., Easton, MD, USA) with colonic manometry (CM) in children with chronic idiopathic constipation (CIC). The secondary objective was to determine the clinical utility of these studies in directing treatment strategies.Methods: A retrospective chart review of 44 children with CIC was evaluated with both OTT and CM. The median follow-up was one year (0.3 to 7).Results: Seventeen children had normal OTT, and 27 had abnormal OTT (slow-transit constipation (STC)). There was no statistical difference between the percentage of children with abnormal CM (13) test results categorized by OTT (23.5% normal OTT vs. 33% abnormal OTT, p = 0.73). A change in therapy was accepted by all 13 children with abnormal CM, but only 26/31 (84%) of the children had normal CM. The CM test results prompted acceptance of treatment change (appendicectomy or medication escalation) in 89% of children. Overall, 31/44 (70%) of children undergoing CM testing had improvement in clinical symptoms. More children with abnormal CM testing improved vs. normal CM but did not reach significance (85% vs. 65%, p = 0.28). Conclusion: Contrary to previous studies, OTT results did not predict the presence of colonic dysmotility based on colon motility testing. Colonic manometry testing resulted in the acceptance of a change in therapy in approximately 90% of children. More children with colonic dysmotility improved versus those with normal CM studies. Other interventions beyond stimulant laxatives should be considered in children with refractory constipation.

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Does the Oral-Anal Transit Test Correlate with Colonic Manometry Findings in Children with Refractory Constipation?

Cited by 6 publications

References 18 publications

Colonic Function Investigations in Children

Colonic Function Investigations in Children

Dyssynergic Defecation in Chronically Constipated Children in Korea

Oro-Anal Transit Time and Colon Manometry: Predictability and Outcomes in Children With Functional Constipation

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