Does the sedative agent, JM-1232(−) cause QT prolongation with subsequent torsades de pointes?

Kato, Ryuichi; Watanabe, Rei; Miki, Haruna; Ijiri, Yoshio; Hayashi, Toshio; Tanaka, Kazuhiko

doi:10.1016/j.lfs.2009.10.002

Cited by 3 publications

(3 citation statements)

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“…A new guideline (ICH S7B) providing provisions for a QT prolongation screening test for new drug development was issued by ICH, the International conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (http://www.ich.org/products/guidelines/safety/article/safety-guidelines.html). Aside from the provided guidelines, it is important to look for substances that do not block K + channels when developing drugs; one can make use of hERG or a screening method using MAP (Kato et al, 2009) .…”

Section: Resultsmentioning

confidence: 99%

“…When comparing QT intervals under different pulse rates, it is standard practice to use the corrected QT interval using Bazett's formula (QTc = QT/ RR ). Other formulae include Fredericia's (QTc = QT/ 3 RR ) and Van de Water's (QTc = QT−0.087×(RR-1000)) (Kato et al, 2009 interval prolongs in bradycardia, while in tachycardia they are larger. Here, we adopt the formula among those mentioned above that shows the lowest correlation between the QTc and the RR interval.…”

Section: What Is Qt Prolongation?mentioning

confidence: 99%

“…MAP 90 (MAP duration at 90% of repolarization) indicates the K + -ion outward current. MAP triangulation (MAP 90-30 ) indicates if Ca 2+ channels or IKr channels are involved (Kato et al, 2009). In the case of arrhythmia from digitalis, Na + / K + -ATPase inhibition increases intracellular Na + which activates the Na + / Ca 2+ exchange mechanism.…”

Section: What Causes Qt Prolongation?mentioning

confidence: 99%

See 2 more Smart Citations

Medicines and QT Prolongation

Kato¹,

Ijiri²,

Tanaka³

2012

Advances in Electrocardiograms - Methods and Analysis

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Section: Resultsmentioning

confidence: 99%

Section: What Is Qt Prolongation?mentioning

confidence: 99%

Section: What Causes Qt Prolongation?mentioning

confidence: 99%

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Medicines and QT Prolongation

Kato¹,

Ijiri²,

Tanaka³

2012

Advances in Electrocardiograms - Methods and Analysis

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Synthesis of novel isoindolone‐based medium‐sized macromolecules and triazole containing heterocyclic compounds

Boddu

Potlapati

Subhashini

2019

Journal of Heterocyclic Chem

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A series of novel isoindolone‐based macromolecules of medium‐sized heterocyclic rings, such as 7,8‐dihydro‐6H‐benzo[4,5][1,6,3]dioxazonino[2,3‐a]isoindol‐14(9aH)‐one derivatives (5a‐l), were synthesized and its frame work incorporating with a triazole moiety on phenol, ie, 2‐(4‐((1‐(2‐methoxyphenyl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)phenyl)isoindoline‐1,3‐dione (9a‐f) and also a triazole moiety on carboxylic acid, ie, (1‐(2‐methoxyphenyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl 4‐(1,3‐dioxoisoindolin‐2‐yl)benzoate derivatives (13a‐e) with various substitutions on aryl ring system have synthesized. All the synthesized compounds were characterized and confirmed with IR, 1H NMR, 13C NMR, and ESI mass spectral analysis.

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Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008

Tor

Yong

et al. 2011

Int. J. Neuropsychopharm.

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Benzodiazepines are commonly prescribed to patients with schizophrenia in many countries, but as little is known about such treatment in Asia, we evaluated their adjunctive use for 6761 in-patients diagnosed with schizophrenia in nine Asian countries using a cross-sectional study design in 2001, 2004 and 2008. Multivariate logistic regression and multivariate linear regression analyses were performed to assess predictors of benzodiazepine use and dose, respectively. Overall, 54% of the patients received adjunctive benzodiazepines at an average daily dose equivalent to 30.3 mg diazepam, with minor changes over the years sampled. Benzodiazepine use was highest in Taiwan and Japan, lowest in Thailand and China, and was associated with fewer years ill, presence of delusions (OR 1.24), hallucinations (OR 1.22), disorganized speech (OR 1.17), social or occupational dysfunction (OR 1.16), and use of mood stabilizers (OR 3.15), antiparkinsonian (OR 1.79) or antidepressant drugs (OR 1.33), and lower doses of antipsychotics (all p=0.016 to <0.001). Benzodiazepine doses were highest in Taiwan and China, lowest in Korea and Singapore; higher doses were associated with being young, male, physically aggressive, receiving mood stabilizers, and having electroconvulsive treatment (all p=0.019 to <0.001). Benzodiazepine use was associated with neurological and systemic adverse effects. In conclusion, benzodiazepine use was common in Asian patients with schizophrenia. Predictors of benzodiazepine use and dose differed in this population. Critical clinical guidelines should be developed specifically for Asian countries to address sound practices in regard to use of benzodiazepines for psychotic disorders.

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Does the sedative agent, JM-1232(−) cause QT prolongation with subsequent torsades de pointes?

Cited by 3 publications

References 16 publications

Medicines and QT Prolongation

Medicines and QT Prolongation

Synthesis of novel isoindolone‐based medium‐sized macromolecules and triazole containing heterocyclic compounds

Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008

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