2022
DOI: 10.3390/jcm11071769
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Does the Serum Concentration of Angiotensin II Type 1 Receptor Have an Effect on the Severity of COVID-19? A Prospective Preliminary Observational Study among Healthcare Professionals

Abstract: SARS-CoV-2 is a virus that causes severe respiratory distress syndrome. The pathophysiology of COVID-19 is related to the renin–angiotensin system (RAS). SARS-CoV-2, a vector of COVID-19, uses angiotensin-converting enzyme 2 (ACE-2), which is highly expressed in human lung tissue, nasal cavity, and oral mucosa, to gain access into human cells. After entering the cell, SARS-CoV-2 inhibits ACE-2, thus favouring the ACE/Ang II/angiotensin II type 1 receptor (AT1R) axis, which plays a role in the development of ac… Show more

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Cited by 5 publications
(4 citation statements)
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“…AngII has many cellular actions via two receptors, the angiotensin I receptor (AT1R) and the angiotensin II receptor (AT2R) [23]. The linkage of AngII with AT1R results in constriction, inflammation, and fibrosis of peripheral vessel walls, while the linkage with AT2R vasodilates and promotes anti-fibrotic and anti-inflammatory actions [24]. The genetic pathways for the production of AT1R and AT2R have been studied as targets for genetic therapy for EH [25].…”
Section: Targeting the Raasmentioning
confidence: 99%
“…AngII has many cellular actions via two receptors, the angiotensin I receptor (AT1R) and the angiotensin II receptor (AT2R) [23]. The linkage of AngII with AT1R results in constriction, inflammation, and fibrosis of peripheral vessel walls, while the linkage with AT2R vasodilates and promotes anti-fibrotic and anti-inflammatory actions [24]. The genetic pathways for the production of AT1R and AT2R have been studied as targets for genetic therapy for EH [25].…”
Section: Targeting the Raasmentioning
confidence: 99%
“…Due to the fact that SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE-2) as a receptor enabling human infection, research has been undertaken on a possible relationship between angiotensin 1 receptor (AT1R) levels in the serum and the course of the disease. However, Janc et al [ 16 ] did not show the effect of AT1R on the severity of symptoms associated with COVID-19 among healthcare professionals and any prognostic significance. On the other hand, San-Cristobal et al [ 17 ], based on the analysis of clinical and biochemical variables obtained in the first 72 h of hospitalization from 1039 COVID-19 patients, specified three clusters with different clinical severity outcomes.…”
Section: Predictors Of the Outcomementioning
confidence: 99%
“…Ainda não há tantos estudos realizados que investigam a presença do receptor ACE2 na cavidade oral. Embora a distribuição do receptor em outras áreas do trato gastrointestinal sugira uma alta presença, como mencionado anteriormente, a disponibilidade de dados é limitada [33]. Análises de mRNA em tecidos normais de uma pequena amostra de pesquisa demonstraram a presença do receptor na cavidade oral, mas em menor número do que em outros órgãos alvo, como pulmões, rins, coração e esôfago [34].…”
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