Does the severity of atopic dermatitis correlate with serum IgE levels?

Laske, Nora; Niggemann, B.

doi:10.1046/j.0905-6157.2003.00106.x

Cited by 127 publications

(114 citation statements)

References 8 publications

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“…33 Taken together, these observations underline the concept that high levels of IL-5 associated with high levels of IgE and a higher degree of eczema in AD may be predictive for a clear risk of inflammation of the upper and lower airways marching to the development of rhinitis and asthma. 34,35 In conclusion, this study shows a relevant contribution of FE NO and of some mediators present in EBC as markers of upper and lower airway inflammation in children with atopic diseases. The presence of low values of these markers in a subgroup of patients overlapping with the normal subjects suggests the need for further studies to identify a cutoff to define the normal and the pathologic ranges of these parameters.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive methods for the detection of upper and lower airway inflammation in atopic children

Profita

Grutta²,

Carpagnano

et al. 2006

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Noninvasive methods for the detection of upper and lower airway inflammation in atopic children

Profita

Grutta²,

Carpagnano

et al. 2006

Journal of Allergy and Clinical Immunology

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“…10,41 Our study revealed that the total IgE level was correlated with the objective SCORAD index and the pruritus score. In addition, a higher IgE level was associated with lower sleep efficiency, more wakefulness in sleep, and more sleep fragmentation.…”

Section: Figurementioning

confidence: 94%

“…The total serum IgE level has been reported to be associated with pruritus and sleep loss in patients with AD, 10,41 and whether it is associated with disease severity is controversial. 10,41 Our study revealed that the total IgE level was correlated with the objective SCORAD index and the pruritus score.…”

Section: Figurementioning

confidence: 99%

Atopic Dermatitis, Melatonin, and Sleep Disturbance

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: Sleep disturbance affects 47% to 60% of children with atopic dermatitis and is a leading cause of impaired quality of life for the patients and their family. WHAT THIS STUDY ADDS:Sleep disturbance in children with atopic dermatitis can be predicted by a Scoring Atopic Dermatitis index of $48.7, and lower nocturnal melatonin secretion might play a role in the pathophysiology. abstract BACKGROUND AND OBJECTIVES: Sleep disturbance is common in patients with atopic dermatitis (AD). However, studies have largely been questionnaire-based, and the pathophysiology remains unclear. The aims of this study were to determine objective characteristics of sleep disturbance in children with AD and explore contributing factors and clinical predictors.METHODS: Sleep parameters were measured by actigraphy and polysomnography in 72 patients with AD and 32 controls ages 1 to 18 years. Urinary 6-sulfatoxymelatonin levels, serum cytokines, and total and allergen-specific immunoglobulin E (IgE) levels were also measured. RESULTS:The patients with AD had significantly reduced sleep efficiency, longer sleep onset latency, more sleep fragmentation, and less nonrapid eye movement sleep. Results from actigraphy correlated well with those from polysomnography. The AD disease severity was associated with sleep disturbance (r = 0.5520.7), and a Scoring Atopic Dermatitis index of $48.7 predicted poor sleep efficiency with a sensitivity of 83.3% and a specificity of 75% (area under the curve = 0.81, P = .001). Lower nocturnal melatonin secretion was significantly associated with sleep disturbance in the patients with AD. Other correlates of sleep disturbance included pruritus, scratching movements, higher total serum IgE levels, and allergic sensitization to dust mite and staphylococcal enterotoxins. CONCLUSIONS:Poor sleep efficiency is common in children with AD and can be predicted by the Scoring Atopic Dermatitis index. Melatonin and IgE might play a role in the sleep disturbance. Further studies are required to explore the mechanisms and clinical implications, and actigraphy could serve as a useful evaluating tool. Atopic dermatitis (AD) is a common chronically relapsing pruritic inflammatory skin disease. 1 Disturbed sleep is frequently reported by the patients and their family and is a major factor leading to an impaired quality of life. [2][3][4] Sleep disturbance can have many negative consequences, including impaired neurocognitive function, higher rates of behavioral problems, and changes in mood. 5,6 Therefore, the recognition and proper management of sleep disturbance should be an important issue in AD.The sleep disturbance in AD might be due to the pruritus and scratching movements during sleep, 7-10 but it is likely that other factors are involved. 11 Melatonin is a hormone secreted by the pineal gland that is essential for regulating the circadian rhythm. 12 Dysfunction in the diurnal secretion of melatonin in patients with AD has been reported, 13 but its association with their sleep disturbance has...

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“…Çalışmalarda çocukluk çağı AD ağırlığı ile serum IgE düzeyleri arasında bir korelasyon saptanmıştır (33,34 …”

Section: Discussionunclassified

Ev Tozu Akarı Duyarlı Atopik Dermatitli Çocuklarda D Vitaminin Etkisi

Nain¹,

Kıykım²,

Yaşöz³

et al. 2017

Asthma Allergy Immunol

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ÖZAmaç: Atopik dermatit (AD) International Study of Asthma and Allergies in Childhood (ISAAC) tarafından yapılan çalışmalarda 6-7 yaş arası çocuklarda İran' da %2' den az, Japonya ve İsveç' de %16, 13-14 yaş grubu çocuklarda Arnavutluk'ta %1'in altında, Kuzey Avrupa' da %15 üzeri saptanmıştır. Ev-tozu akarı (ETA) duyarlılığı AD' de farklı bir klinik oluşturmaktadır. Çalışmamızda ETA duyarılı AD'li hastalarda hastalık şiddetini etkileyen faktörleri belirlemeyi amaçladık.Gereç ve Yöntem: 2014-2015 yılları arasında kliniğimizde ETA'na duyarlı AD tanısıyla izlenen 33 hasta çalışmaya alındı. Başvuru yakınmaları, başvuru ve tanı yaşları, doğum şekli, 1. derece aile bireylerinde atopi, allerjen duyarlılıkları, kan eozinofil, immünoglobulin ve D vitamini düzeyleri, tedavileri ve tedavi yanıtları değerlendirildi. Bulgular: Başvuru yakınmalarının %81.8'i kaşıntı (n=27), %45.5'i döküntü (n=15), %9.1'i kuruluk (n=3) idi. Başvuru sırasında ortalama objektif SCORAD (scoring atopic dermatitis) 45±15 hesaplandı. Objektif SCORAD değerine göre 21 hasta ağır AD olarak değerlendirildi. Hastaların %71.9'unda allerjik astım (AA), %62.5'inde allerjik rinit (AR), %27.3'ünde gıda allerjisi vardı. Maternal atopi 10 (%34.5), paternal atopi 4 (%13.8), kardeşte atopi 6 (%20.7) olarak saptandı. On altı hastanın (%57.1) D vitamini düşük saptandı. Ailede atopi, doğum şekli ve cinsiyet açısından gruplandığında ETA duyarlı AD hastalarında semptom başlangıç ve tanı yaşları, laboratuvar parametreleri ve objektif SCORAD değerleri açısından anlamlı fark yoktu. D vitamini düşük olgularda serum IgA ve IgG düzeyleri anlamlı düşük, spesifik IgE Dermatophagoides ABSTRACT Objective: Atopic dermatitis (AD) in studies conducted by the International Study of Asthma and Allergies in Childhood (ISAAC), children aged 6-7 years accounted for less than 2% in Iran, 16% in Japan and Sweden, and 13-14 years in Albania less than 1%, and over 15% in Northern Europe. House dust mite (HDM) sensitivity confers a distinct phenotype in AD. The current study aimed to determine the factors influencing the disease severity in HDMsensitized AD patients. Materials and Methods:Thirty-three patients with HDMsensitized AD were enrolled in the study. The medical charts were retrospectively evaluated for complaints, age at admission and diagnosis, delivery, gender, atopy in family, sensitizations, eosinophil counts, immunoglobulin and Vitamin D levels, treatment modalities and response to treatment. Results:The chief complaint was pruritus in 81.8%, rash in 45.5% and dryness in 9.1% of patients. Objective SCORAD (scoring atopic dermatitis) at admission was 45±15. Severe AD was detected in 21 patients according to their objective SCORAD index. Accompanying allergic diseases were allergic asthma (AA) in 71.9%, allergic rhinitis (AR) in 62.5% and food allergy in 27.3% of the patients. Sixteen (57.1%) patients showed decreased vitamin D levels. When familial atopy, type of delivery, and gender were set as grouping items, age at disease onset and diagnosis, laboratory parameters and obje...

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Does the severity of atopic dermatitis correlate with serum IgE levels?

Cited by 127 publications

References 8 publications

Noninvasive methods for the detection of upper and lower airway inflammation in atopic children

Noninvasive methods for the detection of upper and lower airway inflammation in atopic children

Atopic Dermatitis, Melatonin, and Sleep Disturbance

Ev Tozu Akarı Duyarlı Atopik Dermatitli Çocuklarda D Vitaminin Etkisi

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