Does transferrin have a special role in the nervous system?

Monteros, Alejandro Espinosa de los; Peña, Louis A.; Vellis, Jean de

doi:10.1002/jnr.490240202

Cited by 64 publications

(37 citation statements)

References 127 publications

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“…Positioned dorsally to the hypoglossal nucleus, the nucleus of the solitary tract (Sol) is labeled on both sides, while the dorsal motor nucleus of the vagus nerve (10) is unlabeled. (Bars = 500 *m.) it is noteworthy that the expression of the receptor for transferrin, a substance known to have a critical role in several growth processes (22), is markedly up-regulated in axotomized motoneurones (23). Similarly, the expression of nerve growth factor receptor mRNA is developmentally regulated and increased in rat spinal cord motoneurones after axotomy (24).…”

Section: Discussionmentioning

confidence: 97%

Axotomy induces the expression of vasopressin receptors in cranial and spinal motor nuclei in the adult rat.

Tribollet

Arsenijévic²,

Marguerat³

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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8-L-Aine vasopressin ([Arg8]VP) receptors are expressed transiently in the rat facial nucleus during the perinatal period. Electrophysiological studies suggest that at least part of these receptors is located on facial motoneurones. In the present study we report that, in the adult rat, unilateral section of a facial nerve results In a massive and transient reexpression of [Arg8JVP receptors in the deeflerented facial nucleus. Data MATERIAL AND METHODS Animals and Surgery. Experiments were performed on adult male rats from a Sprague-Dawley-derived strain. They had free access to water and food pellets. Lights were on from 0700 to 1900, and temperature was maintained around 20'C. Surgery was performed at the age of 4-5 weeks under pentabarbital anesthesia.Altogether, 39 rats were used. In 35 animals, the right facial nerve was cut about 1 mm distal to the stylomastoid foramen. All branches of the nerve were sectioned, with the exception of the posterior auricular branch. Groups of 5-10 animals were subjected to nerve section on the same day and killed at various postoperative times; their brain was cut in coronal sections and processed in a single autoradiographic experiment. The 6 animals of the first group were killed 3-28 days after nerve section; the 10 rats of the second group survived 1-44 days after surgery; the 10 rats of the third group were killed in pairs on postoperative days 8, 10, 13, 16, and 20, respectively; the 9 animals of the fourth group were killed after 4-35 days. In 2 of the remaining 4 animals, the right hypoglossal nerve was exposed at the level of the digastric muscle and cut. In the other 2 remaining rats, the sciatic nerve was exposed and cut in the thigh. These last 4 animals were killed 14 days after surgery. In all animals, the side controlateral to the nerve section served as control. tTo whom reprint requests should be addressed. %36The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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Section: Discussionmentioning

confidence: 97%

Axotomy induces the expression of vasopressin receptors in cranial and spinal motor nuclei in the adult rat.

Tribollet

Arsenijévic²,

Marguerat³

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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“…We found that the treatment of demyelinated rats with a single apotransferrin (aTf) (350 ng) injection at the time of CPZ withdrawal induces a marked increase in myelin deposition as compared to the spontaneous remyelination observed in control animals (Adamo et al 2006). Accordingly, different authors have reported the relevant role of aTf during myelination increasing brain myelin content, including proteins and their mRNAs (Escobar Cabrera et al 1997, regulating MBP gene transcription (Espinosa de los Monteros et al 1989Monteros et al , 1999, synergizing with insulin growth factor-1 (IGF-1), and enhancing myelination in myelin-deficient rats (Espinosa-Jeffrey et al 2002). We recently observed that both canonical and non-canonical Notch signaling pathways are involved in demyelination/ remyelination.…”

Section: Underlying Mechanisms In Demyelination/ Remyelination Processesmentioning

confidence: 97%

Nutritional factors and aging in demyelinating diseases

Adamo

2013

Genes Nutr

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Demyelination is a pathological process characterized by the loss of myelin around axons. In the central nervous system, oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Remyelination is a regenerative process by which myelin sheaths are restored to demyelinated axons, resolving functional deficits. This process is often deficient in demyelinating diseases such as multiple sclerosis (MS), and the reasons for the failure of repair mechanisms remain unclear. The characterization of these mechanisms and the factors involved in the proliferation, recruitment, and differentiation of oligodendroglial progenitor cells is key in designing strategies to improve remyelination in demyelinating disorders. First, a very dynamic combination of different molecules such as growth factors, cytokines, chemokines, and different signaling pathways is tightly regulated during the remyelination process. Second, factors unrelated to this pathology, i.e., age and genetic background, may impact disease progression either positively or negatively, and in particular, age-related remyelination failure has been proven to involve oligodendroglial cells aging and their intrinsic capacities among other factors. Third, nutrients may either help or hinder disease progression. Experimental evidence supports the anti-inflammatory role of omega-6 and omega-3 polyunsaturated fatty acids through the competitive inhibition of arachidonic acid, whose metabolites participate in inflammation, and the reduction in T cell proliferation. In turn, vitamin D intake and synthesis have been associated with lower MS incidence levels, while vitamin D-gene interactions might be involved in the pathogenesis of MS. Finally, dietary polyphenols have been reported to mitigate demyelination by modulating the immune response.

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“…During the development of the CNS, Tf is present in various cell types as they differentiate [Espinosa de los Monteros et al, 1988;Condorelli et al, 1991], and it has been found that there is a close correlation between Tf gene expression and oligodendroglial cell (OLGc) differentiation and myelination [Espinosa de los Monteros et al, 1989]. In the rat brain, both Tf immunoreactivity and Tf mRNA are confined to oligodendrocytes and the choroid plexus [Bloch et al, 1985;Fine, 1986, 1987] and cell culture studies have demonstrated the synthesis of Tf by epithelial cells of the choroid plexus [Aldred et al, 1987] and by oligodendrocytes [Espinosa de los Monteros et al, 1990].…”

Section: Introductionmentioning

confidence: 99%

Apotransferrin Decreases Migration and Enhances Differentiation of Oligodendroglial Progenitor Cells in an in vitro System

et al. 2002

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We have previously shown that a single intracranial injection of apotransferrin (aTf) in neonatal rats produces an accelerated mylinogenesis and increases the expression of certain myelin proteins such as myelin basic protein (MBP). In the present work, we studied the effects of aTf upon oligodendrocyte progenitor cell (Opc) cultures. In the presence of aTf, cells developed a multipolar morphology and showed an increased expression of O₄, MBP, O₁ and myelin-associated glycoprotein compared to controls. Migration studies using the agarose drop assay showed that aTf strongly inhibited OPc migration. This effect was not observed when an antibody against the transferrin receptor was added. The expression of two cell adhesion molecules, neural cell adhesion molecule (NCAM), N-cadherin and of polysialylated NCAM (PSA-NCAM) was evaluated by immunocytochemistry and by Western blot. Although NCAM expression did not change, there was a significant increase in N-cadherin expression and a decrease in PSA-NCAM in the aTf-treated cells. Time lapse studies of the expression of PSA-NCAM as an indicator of migration and of MBP as a marker of differentiation showed that in the cultures treated with aTf there is first a decrease in the percentage of cells expressing the former molecule which is followed by an increase in the percentage of cells expressing MBP. These results suggest that aTf added in vitro to cultured OPcs inhibits first their migration and then enhances their differentiation.

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Does transferrin have a special role in the nervous system?

Cited by 64 publications

References 127 publications

Axotomy induces the expression of vasopressin receptors in cranial and spinal motor nuclei in the adult rat.

Axotomy induces the expression of vasopressin receptors in cranial and spinal motor nuclei in the adult rat.

Nutritional factors and aging in demyelinating diseases

Apotransferrin Decreases Migration and Enhances Differentiation of Oligodendroglial Progenitor Cells in an in vitro System

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