Does Treatment of Erectile Dysfunction With PDE 5 Inhibitor Tadalafil Improve Quality of Life in Male Patients With Compensated Chronic Liver Disease? A Prospective Pilot Study

Kumar, Alok; Saraswat, Vivek A.; Pande, Gaurav; Kumar, Rajesh

doi:10.1016/j.jceh.2022.01.009

Cited by 3 publications

(1 citation statement)

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“…Nootropics that target phosphodiesterases (PDEs) in the brain have been shown to help neuronal cell function (8,9). PDEs, a large family of enzymes (10), are widely distributed in tissues and break the phosphodiester linkages of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) (11) to produce metabolites such as AMP and GMP, respectively (10), which are indicated to have a role in cognitive function. The PDE family comprises 11 PDEs (PDE1-11) containing >60 isoenzymes with 21 genes and >100 gene variants (12,13).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical identification and in silico study of ethanolic extract of white cabbage as a phosphodiesterase 1B inhibitor

Ahmad,

Lesa,

Ujiantari

et al. 2023

J Herbmed Pharmacol

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Introduction: Memory dysfunction has remained a challenging issue globally. Nootropics have proven fruitful in managing cognitive dysfunction but because of their side effects, opportunities exist to explore alternatives. White cabbage is a cost-effective natural source of phytochemicals without side effects and has remained uninvestigated as a nootropic agent. This study sought to identify secondary metabolites in white cabbage extract (WCE) and to predict the molecular interaction between the phytochemical constituents of cabbage and phosphodiesterase-1B (PDE1B) using in silico studies. Methods: The WCE was prepared by macerating crushed fresh white cabbage with ethanol for 24 h with continuous stirring. The phytochemical profile of WCE was analyzed using thin layer chromatography (TLC)-densitometry, and molecular docking studies were performed to predict the underlying mechanism action of the phytochemicals with PDE1B. Results: The TLC-densitometry analysis showed that WCE was a rich source of sinigrin, whereas quercetin, chlorogenic acid, and rutin were not detected. In silico studies identified neobrassicin as having the highest affinity (∆Gbind: −19.3358 kcal/mol) for PDE1B. However, quercetin (∆Gbind: −13.1813 kcal/mol) and chlorogenic acid (∆Gbind: −14.8706 kcal/mol) exhibited moderate interaction with PDE1B. Conclusion: These results suggest that WCE has the potency to improve memory function by blocking PDE1B, and this preliminary study implies upcoming in vitro and in vivo research.

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Section: Introductionmentioning

confidence: 99%

Phytochemical identification and in silico study of ethanolic extract of white cabbage as a phosphodiesterase 1B inhibitor

Ahmad,

Lesa,

Ujiantari

et al. 2023

J Herbmed Pharmacol

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Etiological Spectrum of Cirrhosis in India: A Systematic Review and Meta-analysis

Swaroop,

Vaishnav,

Arora

et al. 2024

Journal of Clinical and Experimental Hepatology

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Chronic liver diseases and erectile dysfunction

Zang

Sun

et al. 2023

Front. Public Health

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Chronic liver diseases (CLDs) are characterized by progressive necrosis of hepatocytes, which leads to liver fibrosis and cirrhosis, and ultimately liver dysfunction. The statistics of 2020 shows that the number of patients with CLDs, including chronic hepatitis, fatty liver, and cirrhosis, may exceed 447 million in China. The liver is a crucial organ for the metabolism of various substances, including sex hormones and lipids. CLDs frequently result in abnormalities in the metabolism of sex hormones, glucose, and lipids, as well as mental and psychological illnesses, all of which are significant risk factors for erectile dysfunction (ED). It has been reported that the prevalence of ED in male patients with CLDs ranges from 24.6 to 85.0%. According to a survey of Caucasians, liver transplantation may improve the erectile function of CLDs patients with ED. This finding supports the link between CLDs and ED. In addition, ED is often a precursor to a variety of chronic diseases. Given this correlation and the significant prevalence of CLDs, it is important to evaluate the epidemiology, risk factors, etiology, and treatment outcomes of ED in male patients with CLDs, expecting to attract widespread attention.

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Does Treatment of Erectile Dysfunction With PDE 5 Inhibitor Tadalafil Improve Quality of Life in Male Patients With Compensated Chronic Liver Disease? A Prospective Pilot Study

Cited by 3 publications

References 48 publications

Phytochemical identification and in silico study of ethanolic extract of white cabbage as a phosphodiesterase 1B inhibitor

Phytochemical identification and in silico study of ethanolic extract of white cabbage as a phosphodiesterase 1B inhibitor

Etiological Spectrum of Cirrhosis in India: A Systematic Review and Meta-analysis

Chronic liver diseases and erectile dysfunction

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