Does trypsin extract soluble antigen meet the criteria of immunogenicity without allergenicity?

Immunity to tuberculosis from the perspective of pathogenesis

“…The animal model for his principal assay of protection involved measurement of differences in lung density in mice given TESA in adjuvant or adjuvant alone and subsequently challenged intravenously with 0.03 mg of virulent tubercle bacilli (4). Smith et al (33) measured the protective activity of TESA in adjuvant (provided by Crowle) in guinea pigs infected by the respiratory route with three to five virulent tubercle bacilli. Protection was judged by the extent to which vaccination inhibited bacillemia.…”