Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?

Kocot, Joanna; Luchowska-Kocot, Dorota; Kiełczykowska, Małgorzata; Musik, Irena; Kurzepa, Jacek

doi:10.3390/nu9070659

Cited by 192 publications

(110 citation statements)

References 205 publications

(289 reference statements)

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“…Some articles demonstrated the association between poor vitamin C and increased depression symptoms [70,71], between DM and depression [72] and between severe PD [73] and depression. Studies have shown that depression is a consequence of inadequate levels of ascorbic acid [74].…”

Section: Discussionmentioning

confidence: 99%

Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association

et al. 2020

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Ascorbic acid (vitamin C) is an important water-soluble vitamin found in many fruits and vegetables. It has well-documented beneficial effects on the human body and is used as a supplement, alone or in combination with other vitamins and minerals. Over recent years, research has focused on possible new therapeutic actions in chronic conditions including periodontal disease (PD). We conducted a systematic review on clinical trials from four databases (PubMed, Clinical Trials, Cochrane, Web of Science) which measured plasmatic/salivary levels of ascorbic acid in PD–diabetes mellitus (DM) association. Six studies were included in our review, three of them analyzing patients with different grades of PD and DM who received vitamin C as a treatment (500 mg vitamin C/day for 2 months and 450 mg/day for 2 weeks) or as part of their alimentation (guava fruits), in combination with standard therapies and procedures. Decreased levels of vitamin C were observed in PD patients with DM but data about efficacy of vitamin C administration are inconclusive. Given the important bidirectional relationship between PD and DM, there is a strong need for more research to assess the positive effects of ascorbic acid supplementation in individuals suffering from both diseases and also its proper regimen for these patients.

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Section: Discussionmentioning

confidence: 99%

Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association

et al. 2020

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“…Ascorbate (vitamin C) is a potent antioxidant obtained through the diet. In the brain, ascorbate is maintained at high concentrations relative to other organs [ 13 ], and low levels are linked to neurodegenerative diseases [ 14 , 15 ]. Previous research has indicated that patients with Parkinson’s disease have significantly lower concentrations of plasma ascorbate and higher concentrations of oxidative stress markers compared to healthy controls [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Positive Association of Ascorbate and Inverse Association of Urate with Cognitive Function in People with Parkinson’s Disease

et al. 2020

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Oxidative stress is thought to contribute to the aetiology of neurological disorders such as Parkinson’s disease. Ascorbate (vitamin C) is a potent antioxidant and is associated with neurological and cognitive function. In this study we assessed the ascorbate status of a cohort of people with Parkinson’s disease (n = 215), aged 50–90 years, compared with a cohort of age matched healthy controls (n = 48). The study sample’s cognitive status ranged from normal to mild cognitive impairment and dementia. There was no difference between the Parkinson’s disease and healthy control groups with respect to mean ascorbate status, however, a higher proportion of participants with Parkinson’s disease had hypovitaminosis C (i.e., <23 μmol/L) compared with healthy controls (20% vs. 8%, respectively). Within the Parkinson’s disease group, Montreal Cognitive Assessment (MoCA) scores correlated positively with ascorbate concentrations, with higher ascorbate status associated with better cognitive function (r = 0.14, p = 0.045). Participants with hypovitaminosis C had significantly lower MoCA scores relative to participants with ascorbate concentrations >23 µmol/L (p = 0.014). Ascorbate concentrations were significantly lower in the cognitively impaired subgroup compared with the normal cognition subgroup in the Parkinson’s disease cohort (p = 0.03). In contrast, urate showed an inverse correlation with cognitive function (r = −0.19, p = 0.007), with higher urate concentrations observed in the cognitively impaired subgroup compared with the normal cognition subgroup (p = 0.015). There was an inverse association between ascorbate status and urate concentrations (r = −0.15, p = 0.017). Plasma protein carbonyls, a measure of systemic oxidative stress, were not significantly different between the Parkinson’s disease cohort and healthy controls, and there was no association with cognitive function (r = 0.09, p = 0.19) or with ascorbate status (r = −0.05, p = 0.45). Overall, our study showed ascorbate status was positively associated with cognitive function in Parkinson’s disease, suggesting that longitudinal studies investigating the temporal sequence of cognitive decline and ascorbate status are warranted.

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“…Its ability to effectively disrupt the fibrillogenesis of the A β peptide has already been reported [ 30 ]. Vitamin C ((2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one) is believed to be a vital antioxidant in the brain ( Figure 1(b) ) [ 31 ]. Namely, a huge body of evidence suggests that vitamin C may change the course of neurological diseases and serve as a potential therapeutic tool.…”

Section: Introductionmentioning

confidence: 99%

“…Namely, a huge body of evidence suggests that vitamin C may change the course of neurological diseases and serve as a potential therapeutic tool. Intracellularly, it helps to maintain several key processes, including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission, and antioxidant protection [ 31 ]. Targeted deletion of the sodium-vitamin C cotransporter in mice resulted in widespread cerebral hemorrhage and death [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Protein Aggregation by Several Antioxidants

Hasanbašić

Jahić

Berbić

et al. 2018

Oxidative Medicine and Cellular Longevity

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Amyloid fibril formation is a shared property of all proteins; therefore, model proteins can be used to study this process. We measured protein aggregation of the model amyloid-forming protein stefin B in the presence and absence of several antioxidants. Amyloid fibril formation by stefin B was routinely induced at pH 5 and 10% TFE, at room temperature. The effects of antioxidants NAC, vitamin C, vitamin E, and the three polyphenols resveratrol, quercetin, and curcumin on the kinetics of fibril formation were followed using ThT fluorescence. Concomitantly, the morphology and amount of the aggregates and fibrils were checked by transmission electron microscopy (TEM). The concentration of the antioxidants was varied, and it was observed that different modes of action apply at low or high concentrations relative to the binding constant. In order to obtain more insight into the possible mode of binding, docking of NAC, vitamin C, and all three polyphenols was done to the monomeric form of stefin B.

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Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?

Cited by 192 publications

References 205 publications

Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association

Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association

Positive Association of Ascorbate and Inverse Association of Urate with Cognitive Function in People with Parkinson’s Disease

Inhibition of Protein Aggregation by Several Antioxidants

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