Background. Medical events are often reported as triggers for weight loss, but it is unknown whether medical triggers result in better short-and long-term weight control.Methods. The relationship between medical triggers and weight loss was examined in the National Weight Control Registry (NWCR), a database of individuals who have lost z30 lbs and kept it off for z1 year. Recall of weight loss triggers may become difficult over time, thus participants were limited to those reporting weight loss <5 years ago. Three groups were examined: (1) participants with medical triggers (N = 207), (2) participants with nonmedical triggers (N = 539), and (3) participants with no trigger (N = 171).Results. Participants with medical triggers were older than those with nonmedical triggers or no trigger (50.5 F 11.7, 44.9 F 11.8, 46.7 F 13.3 years; P = 0.0001), had a higher initial BMI at entry into the NWCR (26.1 F 5.0, 25.0 F 4.3, 24.8 F 4.4 kg/m