Dominant lethal test in the mouse for mutagenic effects of saccharine

Machemer, L.; Lorke, Dietrich

doi:10.1007/bf00282194

Cited by 7 publications

(9 citation statements)

References 3 publications

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“…In mice, NMRI strain were the most used ( 34 , 35 ) one study used ICR mice, and one study used BALB/C mice ( 36 ). Five types of sweeteners were used (rebaudioside A—three papers, saccharin—three papers, advantame—one paper, aspartame—one paper, and sucralose—one paper) and were mostly administered to the rodent's feed or drinking water ( 29 , 30 , 33 , 35 – 37 ) (see Table 2 ). Two studies used oral/aqueous gavage ( 32 , 34 ) and one study used gastric tubing to administer the NCS ( 31 ).…”

Section: Resultsmentioning

confidence: 99%

“…Sperm concentration was recorded in the majority of studies ( 30 – 34 , 36 , 37 ) and sperm quality was assessed in over half (5/9) of the studies ( 30 , 33 , 34 , 36 , 37 ). Pregnancy success was only studied in one paper ( 35 ). Reproductive organ weight or damage was recorded in 5 studies ( 29 – 31 , 34 , 37 ).…”

Section: Resultsmentioning

confidence: 99%

“…Only one study investigated pregnancy success as shown in Table 2 , following saccharin consumption in males ( 35 ). Mice were given saccharin for 5 days and then mated with untreated females to assess fertility and implantation loss.…”

Section: Resultsmentioning

confidence: 99%

“…In relation to species and strain, Wistar rats were used for most studies (29)(30)(31), followed by two studies in Sprague-Dawley rats (32,33). In mice, NMRI strain were the most used (34,35) one study used ICR mice, and one study used BALB/C mice (36). Five types of sweeteners were used (rebaudioside A-three papers, saccharinthree papers, advantame-one paper, aspartame-one paper, and sucralose-one paper) and were mostly administered to the rodent's feed or drinking water (29,30,33,(35)(36)(37) (see Table 2).…”

Section: Study Characteristicsmentioning

confidence: 99%

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The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models

2022

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Understanding the factors which influence fertility is essential for developing appropriate nutritional recommendations for couples trying to conceive. Non-caloric sweeteners (NCS) are increasing in the food chain and despite being no/low calorie, several adverse metabolic consequences have been attributed to their consumption. Their effects on reproduction have been relatively under-researched, particularly in males. This review aims to systematically review the literature for evidence of the effect of NCS on male fertility in rodents, with sperm parameters (sperm quantity and quality) assessed as primary outcomes. Given the lack of information available in humans this review has been carried out using evidence from rodent models. Risk of bias assessment was carried out using the Syrcle risk of bias tool. Nine studies met the inclusion criteria. Forty-four percent showed a negative effect of NCS on male reproductive parameters compared with controls. The effects of NCS on fertility have been conflicting and selected studies have been heterogeneous in relation to study design. It is unclear if NCS has an impact on male reproductive function. There is a need for randomized controlled trials using a standardized protocol for analysis, to formulate a clear message in terms of male fertility.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models

2022

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“…Despite being resource intensive, this assay is still used for regulatory testing of chemicals and/or mutagens. This assay also requires hundreds of animals, is labour and time intensive, and is expensive [13,18].…”

Section: Traditional Germ Cell Mutation Assaysmentioning

confidence: 99%

Effects of exposure in utero to diesel exhaust particles : mutation rates in the developing male and female germline

Ritz¹

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Einfluß einer mehrwöchigen Behandlung männlicher und weiblicher Mäuse mit Saccharin, Cyclamat oder Cyclohexylaminsulfat auf Fertilität und Dominant-Letal-Effekte

Lorke

Machemer

1975

Hum Genet

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Dominant lethal test in the mouse for mutagenic effects of saccharine

Cited by 7 publications

References 3 publications

The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models

The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models

Effects of exposure in utero to diesel exhaust particles : mutation rates in the developing male and female germline

Einfluß einer mehrwöchigen Behandlung männlicher und weiblicher Mäuse mit Saccharin, Cyclamat oder Cyclohexylaminsulfat auf Fertilität und Dominant-Letal-Effekte

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