2013
DOI: 10.3109/15622975.2013.841993
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Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression

Abstract: We describe novel behavioural and biochemical abnormalities in the DN-DISC1 mouse model of schizophrenia. The data shows for the first time a possible link between DISC1 mutation and the cannabinoid system.

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Cited by 25 publications
(18 citation statements)
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“…Furthermore, as social abilities require non-social cognitive processes, alterations in social recognition can be a consequence of impaired non-social cognition. In this context, and in contrast to other models of schizophrenia (Kaminitz et al 2014; Zoubovsky et al 2015), PCP-induced impairment in recognition might not be specific to social stimuli, as observed in a non-social recognition task (Vigano et al 2009). Based on these observations, any attempt to dissociate between social and non-social cognition deficits in PCP-treated animals would be only speculative, and studies aimed at better understanding the underlying mechanisms of these two domains are warranted.…”
Section: Discussionmentioning
confidence: 59%
See 1 more Smart Citation
“…Furthermore, as social abilities require non-social cognitive processes, alterations in social recognition can be a consequence of impaired non-social cognition. In this context, and in contrast to other models of schizophrenia (Kaminitz et al 2014; Zoubovsky et al 2015), PCP-induced impairment in recognition might not be specific to social stimuli, as observed in a non-social recognition task (Vigano et al 2009). Based on these observations, any attempt to dissociate between social and non-social cognition deficits in PCP-treated animals would be only speculative, and studies aimed at better understanding the underlying mechanisms of these two domains are warranted.…”
Section: Discussionmentioning
confidence: 59%
“…Interestingly, this selective impairment of social novelty preference has been reported across a broad range of animal models of schizophrenia (Kaminitz et al 2014; O'Tuathaigh et al 2007; Shimamoto et al 2014; Zoubovsky et al 2015, but O'Tuathaigh et al 2010a). Eagle and co-workers (Eagle et al 2013) proposed that this selective impairment might be related to the differences between sensation-seeking versus novelty-seeking behaviors, the latter requiring to recall and recognize a familiar versus a novel object.…”
Section: Discussionmentioning
confidence: 76%
“…Finally, many of these studies implicated significant alterations in key neurotransmitter systems, including glutamatergic, dopaminergic, cannabinoid, or nicotinic neurotransmission (Jaaro-Peled et al, 2013; Kaminitz et al, 2014; Ballinger et al, 2015; Dawson et al, 2015; Kim et al, 2015). Taken together, these transgenic approaches, coupled with DN-DISC1 constructs, are expected to further contribute to the understanding of pathobiology associated with human psychiatric conditions (Table 1).…”
Section: Transgenic Modelsmentioning
confidence: 99%
“…dominant-negative or C-terminus truncated) DISC1 (Ayhan et al, 2011; Kaminitz et al, 2014; Kuroda et al, 2011; Ma et al, 2013; Ovanesov et al, 2008) . Thus, we performed a series of behavioral tests to assess whether selective expression of mutant DISC1 in PCs would affect different domains of mouse behavioral repertoire.…”
Section: Resultsmentioning
confidence: 99%