Don’t edit the human germ line

Gene Editing in Clinical Practice

“…As rightly pointed out by Lanphier et al [5], the public outcry about the ethical breach of human embryo genome editing could hinder the promising area of therapeutic development that are involved in making genetic changes in somatic cells and there should be an open discussion around the appropriate action should a compelling case arise for therapeutic benefit of germ line modification [5].…”

“…The nuclease may not necessarily cleave both copies of the target gene or the cells may start dividing before the corrections are completed, resulting in genetic mosaic [5]. Mosaicism is the presence of the populations of somatic cells that are genetically distinct in an organism.…”

“…While it is clear that people's informed consent is secured before genetically engineered somatic cells are used in clinical research, it is not clear what information would be needed from the prospective parents to adequately inform them about the risks involved in germ line modification [5]. The scientific community should engage in a dialogue to establish guidelines of research involving genetic modification of human germ cells.…”

Genome-editing revolution: My whirlwind year with CRISPR

“…I wouldn't have blamed my neighbours or friends for saying, "All this was going on and you didn't tell us about it?" The Science perspective, and a related Comment published in Nature the week before 9 , helped to convey the message that those leading the work recognized that they had a responsibility to voice concerns.…”

Genetic engineering: Friend or foe?

“…Nitekim Nisan 2015'te Çin'de yapılan bir araştırma, insan embriyolarıyla oynandığını ortaya koydu bile (14). Mart 2015'te ise, içlerinde CRISPR yönteminin mucitlerinden Jennifer Droudna'nın da bulunduğu bir grup, ortak bir bildiri yayınlayarak embriyolar üzerinde yapılan kalıtılabilir genetik değişim araştırmalarının yasaklanmasını istedi (15,16).…”