Döndürmeli Kaplama Yöntemi ile Kurkumin Kaplanmış Polikaprolakton Nanolif Yara Örtülerinin Hazırlanması ve in vitro Etkinliğinin İncelenmesi

Abstract

therapeutic agents. In this study, the spin coating was employed for the accommodation of, the therapeutics content, curcumin on the nanofibers followed by the investigation of the efficiency of the spin-coating approach for the drug integration on nanofibers to be employed as a wound dressing. The results showed that accommodation of curcumin onto nanofibers was performed successfully by spin-coating and more than 50% of accommodated curcumin was released in 2 hours. Furthermore, drug-loaded nanofibers improved fibroblast cell proliferation for 24h in comparison to pristine nanofiber. In view of all, curcumin deposited nanofibers are considered as profitable for connective tissue regeneration by means of supporting cell proliferation.