Donepezil, a potential therapeutic agent for heart failure

Chen, Ao; Chen, Yingmin

doi:10.1002/ejhf.214

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…[ 1 , 2 ] Acute coronary syndrome (ACS), characterized by rupture of vulnerable plaque in the coronary arteries and subsequent partial or complete blockage of the vascular lumen, is the most lethal manifestation of CAD. [ 3 , 4 ] Indeed, complications of ACS, including acute cardiac failure, ventricular rupture, and malignant arrhythmia, are associated with a high mortality rate. [ 5 ] The overall survival of patients with ACS has improved with the use of antiplatelet drugs and statins, and more importantly, with timely revascularization via percutaneous coronary intervention (PCI) and coronary artery bypass graft.…”

Section: Introductionmentioning

confidence: 99%

MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome

Wang²,

Zhang³

et al. 2017

Medicine

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The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, circulating levels of homocysteine (Hcy), and the severity of coronary lesion in patients with acute coronary syndrome (ACS) remains unknown.Consecutive ACS patients were included. MTHFR C677T polymorphisms were determined via amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Gensini scores were used to evaluate the severity of coronary lesions.Three hundred ten ACS patients were included, and grouped according to the MTHFR C677T polymorphism variant: CC (n = 78, 25.2%), CT (n = 137, 44.2%), and TT (n = 95, 30.6%) groups. No significant differences were detected with respect to baseline characteristics. Patients in TT group had significantly higher Hcy, and significantly lower folic acid (FA) levels as compared with those in the other 2 groups (P < .05 for both). More importantly, patients with TT had more severe coronary lesions as compared with those from the other 2 groups, as evidenced by higher Gensini scores (P < .05 for both); however, no significant differences were observed with respect to the numbers of affected coronary arteries, or the number, length, and diameter of stents implanted in each group (P > .05 for all). On multivariate logistic regression analysis, presence of a T allele in MTHFR C677T was found to be independently associated with higher circulating Hcy (odds ratio [OR] = 1.06, 95% confidence interval [CI]: 1.01–1.12, P = .024), and higher Gensini scores (OR: 1.01, 95% CI: 1.00–1.02, P = .046).MTHFR C677T TT polymorphism was associated with higher Hcy levels and more severe coronary lesions in patients with ACS.

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Section: Introductionmentioning

confidence: 99%

MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome

Wang²,

Zhang³

et al. 2017

Medicine

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Autonomic Modulation in Heart Failure: Ready for Prime Time?

2015

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It has been known for many decades that multiple abnormalities of the autonomic nervous system (ANS) are present in heart failure (HF). Moreover, many of the effective therapies currently used to treat HF have either direct or indirect effects on the ANS. While therapies that block over-activity of the sympathetic nervous system are now standard of care, much less well studied are therapies aimed at augmenting the parasympathetic nervous system. This review will cover recent and ongoing investigations targeting modulation of the ANS, especially highlighting new and ongoing studies directed toward augmenting parasympathetic mechanisms.

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Expert Center for cardiac amyloidosis: reality and perspectives

Nasonova,

Zhirov,

Shoshina

et al. 2024

Terapevticheskii arkhiv

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Aim. To evaluate the features of diagnosis of amyloid cardiomyopathy (ACMP), differential diagnosis of different types of amyloidosis and its clinical manifestations. Materials and methods. Were analyzed 150 cases of patients who consulted at the Expert Center for Amyloidosis with suspicion of the presence of ACMP. 63 patients were diagnosed with ACMP: 25 (39.7%) – women, 38 (60.3%) – men, with an average age of 64.1±1.5. 36 (57.1%) patients had AL-amyloidosis (immunoglobulin amyloid light-chain amyloidosis), 25 (39.7%) – ATTR-amyloidosis (transthyretin amyloidosis), 2 (3.2%) – AA-amyloidosis with heart failure (reactive systemic amyloidosis caused by hypersecretion of á-globulin). The analysis of clinical manifestations depending on the type of amyloidosis, data of laboratory and instrumental methods of diagnosis is carried out. Results. In most cases, 53 (84.1%) patients, amyloidosis manifested as signs of heart failure. Among cardiac manifestations, shortness of breath (95.2%), general weakness (93.7%), lower limb edema (76.2%) were the most common. To confirm the diagnosis, despite the high accuracy of the speckle-tracking echocardiography and magnetic resonance imaging of the heart with gadolinium, in rare cases a biopsy is required (e.g. there is a combination of clinical signs of several types of amyloidosis). Biopsy of the affected organ was performed in 31 (49.2%) patients. The strategy for further pathogenetic treatment depends on the determination of the type of amyloidosis. Free light chains of immunoglobulins were detected in 57.1% of cases, which allowed diagnosis of AL-amyloidosis. In 17 (38.6%) patients myocardial scintigraphy with 99mTc-pyrophosphate showed signs of ATTR-amyloidosis, which with a negative result of immunochemical studies allows non-invasive diagnosis of it. Conclusion. ACMP is a disease with an extremely adverse prognosis. Raising the awareness of specialists about ACMP is an important goal. With timely diagnosis, pathogenetic therapy can be started early, which will improve the quality of life and prognosis of patients with ACMP.

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Donepezil, a potential therapeutic agent for heart failure

Cited by 4 publications

References 6 publications

MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome

MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome

Autonomic Modulation in Heart Failure: Ready for Prime Time?

Expert Center for cardiac amyloidosis: reality and perspectives

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