Donor age is paramount to success in oocyte donation *

Cohen, Matthew A.; Lindheim, Steven R.; Sauer, Mark V.

doi:10.1093/humrep/14.11.2755

Cited by 65 publications

(30 citation statements)

References 21 publications

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“…One of the most important issues in an egg donor program is to have a good screening protocol, where only potentially successful donors are accepted into the program. Unfortunately, this is not an easy task and studies showed that selecting only young donors, [16,17] failed to show any variables that would make a difference in future outcome [18][19][20]. In our program, we include donors younger than 35 years old with regular menses, with normal basal FSH/estradiol levels and basal antral follicle count, without androgenic characteristics, and without history of repeated spontaneous miscarriages.…”

Section: Discussionmentioning

confidence: 99%

A shared egg donor program: which is the minimum number of oocytes to be allocated?

Glujovsky¹,

Domínguez²,

Fiszbajn³

et al. 2010

J Assist Reprod Genet

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Purpose To evaluate which is the minimum number of oocytes to be allocated to each recipient in a shared egg donor program. Methods We analyzed 953 recipients that received at least 4 metaphase II (MII) oocytes in the period 2006-2008. We retrospectively divided the recipients according to the number of MII oocytes actually received.Results No statistically significant differences were found among the analyzed strata in clinical pregnancy rate (A:43.7%; B:45.6%; C:48.6%; D:45.5%; E:53%, P=NS) and miscarriage rate. However, the rate of top quality transferred embryos, and the embryo freezing rate were significantly higher among those recipients that received 7 or more mature eggs. Conclusions After a large sample was analyzed, no significant differences in fresh embryo transfer outcome were encountered when a different number of oocytes was allocated. A minimum of 4 MII oocytes seems to achieve satisfactory pregnancy rates in our shared egg donor program.

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Section: Discussionmentioning

confidence: 99%

A shared egg donor program: which is the minimum number of oocytes to be allocated?

Glujovsky¹,

Domínguez²,

Fiszbajn³

et al. 2010

J Assist Reprod Genet

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“…Data from egg-donation programs have shown that the quality of human oocytes decreases with the age of the donor (17). Little is known about the mechanism (but see ref.…”

Section: Significancementioning

confidence: 99%

Reduced fitness in progeny from old parents in a natural population

Schroeder

Nakagawa

Rees

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

140

206

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A nongenetic, transgenerational effect of parental age on offspring fitness has been described in many taxa in the laboratory. Such a transgenerational fitness effect will have important influences on population dynamics, population age structure, and the evolution of aging and lifespan. However, effects of parental age on offspring lifetime fitness have never been demonstrated in a natural population. We show that parental age has sex-specific negative effects on lifetime fitness, using data from a pedigreed insular population of wild house sparrows. Birds whose parents were older produced fewer recruits annually than birds with younger parents, and the reduced number of recruits translated into a lifetime fitness difference. Using a long-term cross-fostering experiment, we demonstrate that this parental age effect is unlikely to be the result of changes in the environment but that it potentially is epigenetically inherited. Our study reveals the hidden consequences of late-life reproduction that persist into the next generation.aging | epigenetic | indirect effects | senescence | transgenerational R eproducing at old age is known to incur costs such as an increased risk of polysomy and higher infant and maternal mortality. One potential cost that is hard to estimate occurs when parental age influences the lifespan or fertility of the next generation and beyond. First described by Alexander Graham Bell (1), this negative influence of parental age on offspring fitness [known as the "Lansing effect" (2-6)] has been observed in humans and in many taxa in the laboratory. Such transgenerational effects might have an epigenetic cause and are critical for understanding the evolution of late reproduction and longevity (7-11). However, to our knowledge, an effect of parental age on fitness in the next generation has not yet been shown conclusively in the wild, perhaps because its detection requires an exact knowledge of parental age and of the lifetime fate of offspring, data that are difficult to gather in natural populations (12). We have data from a natural, pedigreed population of passerines, house sparrows (Passer domesticus), in which we know the life history and precise fitness estimates of nearly all individuals (13). We use these data to demonstrate that parental age has a negative effect on fitness. We complement this study with a long-term cross-fostering experiment (14) that allows us to demonstrate that this effect is not environmentally induced. Our study reveals the hidden consequences of late-life reproduction for the next generation. Such transgenerational effects have the potential to help us better understand the evolution of aging and lifespan. ResultsWe found no statistically significant effect of a parent's age at reproduction on its offspring's longevity (Table 1). However, we found significant, sex-specific evidence for a negative effect of the age of the focal individual's parents on its lifetime reproductive success (the number of genetic recruits over a lifetime, LRS; Fig. 1). Sparrow females ...

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“…To date the majority of published studies are of a retrospective nature analyzing a more or less large consecutive series of recipients. The most studied prognostic factors include donor and recipient age, oocyte donation indication, endometrial thickness, and duration of estrogen replacement (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

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confidence: 99%