Donor citrate reactions influence the phenotype of apheresis platelets following storage

Wal, Dianne E. van der; Davis, April; Marks, Denese C.

doi:10.1111/trf.16729

Cited by 3 publications

(4 citation statements)

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“…Furthermore, these donors generally possess substantial knowledge about the blood donation process, both before and after donation. Consequently, these individuals experience less psychological stress and fewer adverse reactions during donation, aligning with reports from other regions across the country ( 6 ). Notably, the male-to-female ratio among single platelet unpaid blood donors in Zhengzhou is 2.6:1 ( Table 1 ), which is similar to the sex distribution in Zhengzhou ( 7 ) but differs from that in other parts of China ( 11 ).…”

Section: Discussionsupporting

confidence: 76%

“…The clinical demand for apheresis platelets has increased accordingly ( 3 , 4 ). However, due to the protracted collection process ( 5 ), specific storage requirements ( 6 ), and short shelf life of apheresis platelets ( 7 ), recruiting donors for this component has become a challenging endeavor, often resulting demand exceeding the available supply ( 8 ). Public health emergencies exacerbate this challenge and disrupt the balance between the supply and demand for apheresis platelets ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Discussion on the recruitment strategy for apheresis platelet donors in Chongqing during a public health emergency*

Cheng,

Xie,

Tian

et al. 2024

Front. Public Health

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ObjectiveThis study aimed to analyze the population characteristics of apheresis platelet donors in Chongqing Province and provide a scientific basis for the development of precise and efficient recruitment strategies. The ultimate goal is to increase the number of regular platelet donors in preparation for public health emergencies.MethodsThis study involved 53,089 blood donors who donated apheresis platelets to the Chongqing Blood Center from 2020 to 2022. Data regarding age, sex, blood type, education level, occupation, and frequency of blood donation were collected and analyzed to identify factors influencing platelet donation.ResultsBetween 2020 and 2022, the majority of apheresis platelet donors in Chongqing were aged 25–35 years, with a male-to-female ratio of 2.6:1. The ABO blood group distribution was O > A > B > AB. The apheresis platelet donors mainly consisted of college students, and the donors who had donated only once accounted for the greatest proportion.ConclusionBased on the population characteristics of apheresis platelet donors in Chongqing, blood collection and supply organizations must refine emergency blood collection and supply plans during public health emergencies. This study underscores the importance of developing precise and efficient recruitment strategies for apheresis platelet donors and expanding the pool of regular apheresis platelet donors. These measures are essential to ensure the timely, safe, and effective use of clinical blood resources during public health emergencies.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Discussion on the recruitment strategy for apheresis platelet donors in Chongqing during a public health emergency*

Cheng,

Xie,

Tian

et al. 2024

Front. Public Health

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“… 54 It is important to note that we used platelet concentrates and not the routinely used apheresis platelets in this study. 55 , 56 Thus, the data may not be completely representative of glycan topology change in platelets procured by apheresis. However, the data here serve as a foundation to understanding the diverse role of glycans in platelets during storage.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the human platelet N- and O-glycome upon storage using tandem mass spectrometry

et al. 2023

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Changes in surface glycan determinants, specifically sialic acid loss, determine platelet life span. The gradual loss of stored platelet quality is a complex process that fundamentally involves carbohydrate structures. Here, we applied lipophilic extraction and glycan release protocols to sequentially profile N- and O-linked glycans in freshly isolated and seven-day room temperature stored platelet concentrates. Analytical methods including matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), tandem mass spectrometry (MSn), and liquid chromatography (LC) were used to obtain structural details of selected glycans and terminal epitopes. The fresh platelet repertoire of surface structures revealed diverse N-glycans, including high mannose structures, complex glycans with polylactosamine repeats, and glycans presenting blood group epitopes. The O-glycan repertoire was largely comprised of sialylated and fucosylated core-1 and core-2 structures. For both N- and O-linked glycans, we observed a loss in sialylated epitopes with a reciprocal increase in neutral structures as well as increased neuraminidase activity following platelet storage at room temperature. The data indicate that loss of sialylated glycans is associated with diminished platelet quality and untimely removal of platelets following storage.

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“…Given that these are obtained from donors, platelet transfusion entails elements of platelet heterogeneity inherent in the population variables above. Furthermore, heterogeneity in units arises from different donor reactions to apheresis [ 75 ], changes occurring with storage over time [ 76 ], and the specific method of storage [ 77 ]. Progress is being made on ex vivo synthesis of platelets for transfusion [ 78 , 79 ], and their properties compared with those of donor platelets may need to be considered.…”

Section: Platelet Heterogeneity At the Individual Level: Inherited Ac...mentioning

confidence: 99%

Heterogeneity of platelets and their responses

Thomas,

Kelliher,

Krishnan

2024

Research and Practice in Thrombosis and Haemostasis

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Donor citrate reactions influence the phenotype of apheresis platelets following storage

Abstract: Funding informationAustralian Governments fund Australian Red Cross Lifeblood to provide blood, blood products, and services to the Australian community.

Cited by 3 publications

References 20 publications

Discussion on the recruitment strategy for apheresis platelet donors in Chongqing during a public health emergency*

Discussion on the recruitment strategy for apheresis platelet donors in Chongqing during a public health emergency*

Characterization of the human platelet N- and O-glycome upon storage using tandem mass spectrometry

Heterogeneity of platelets and their responses

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