Donor demographic and laboratory predictors of single donor platelet yield

Abstract

Background: Platelet transfusions are essential to prevent morbidity and mortality in patients who are severely thrombocytopenic and are at risk of spontaneous bleeding. Platelets are currently obtained either by fractionation of whole blood or by platelet apheresis. The quality of single donor platelets (SDP) in terms of yield influences platelet recovery in the recipient and allows prolonging intervals between transfusions. Material and Methods: Donor demographic and laboratory data were analyzed prior to performing plateletpheresis to identify donor factors that influence platelet yield. The study was conducted on 130 healthy, first-time plateletpheresis donors over a period of 4 years. The plateletpheresis procedures were performed using Fresenius Kabi COM.TEC and Hemonetics MCS plus separator. A relationship between pre-donation donor variables and yield of platelets was studied using the Pearson correlation. Results: The mean platelet yield was 3.160.62x10 11 per unit. A positive correlation was observed between platelet yield and pre-donation platelet count, body mass index (BMI; Kg/m 2) of the donor, while a negative correlation was observed between age and the platelet yield. Conclusion: Donor pre-donation platelet count, BMI and donor age influence platelet yield. Young healthy donors with a high platelet count and better BMI can give a better platelet yield in the SDP.

Factors influencing plateletpheresis donations in Dr. Sardjito General Hospital, Yogyakarta, Indonesia

“…One study recently concluded that age was negatively and significantly correlated with the yield of plateletpheresis -the older the donor, the lower the yield of plateletpheresis. 9 However, in our study, there is no correlation between age and yield of plateletpheresis (TABLE 4. ).Weight and BMI are several factors from the donor that are believed can influence the yield of plateletpheresis.…”

“…One study revealed that the product volume of plateletpheresis correlated positively and was statistically significant to the yield of plateletpheresis showing that the higher the product volume of plateletpheresis, the higher the yield of plateletpheresis. 9 The study also found that the product volume of plateletpheresis is one of the main factors of the procedural aspects that influence the yield of plateletpheresis. Similarly, in our study, the product volume of plateletpheresis has a positive and statistically significant correlation with the yield of plateletpheresis.…”

“…A study showed that BMI has a positive correlation with the yield of plateletpheresis. 9 However, another study found that weight is not correlated with the yield of plateletpheresis. 10 The BMI reflects weight and body mass in line with the blood volume.…”

An Analysis of Deferral Pattern in Plateletpheresis Donors

“…Plateletpheresis procedure is designed to collect large number of platelets from single donor thereby giving more consistent product. 1 As per guidelines of American association of blood banks plateletpheresis (Single Donor Platelets) unit must have platelet count of 3x 10 11 which in turn raises platelet count by 30,000-60,000 per microlitre and is equivalent to 4-6 units of random platelet concentrates 2 . Besides providing good yield, single donor platelets have numerous advantages over random donor platelets for the recipients which include decreased risk of transfusion transmitted infections, bacterial contamination and alloimmunization due to reduced donor exposure.…”

“…3 Over the years, the demand for single donor platelets has increased manifold. It is estimated that 79% of therapeutic platelet doses transfused in the United States of America are apheresis platelets 1 The demand of plateletpheresis is increasing in our country also mainly because of dengue epidemics since last 10-15 years. 4 Now a days, most of the tertiary care centers are demanding plateletpheresis to increase platelet count of patients.…”