Donor InSight: characteristics and representativeness of a Dutch cohort study on blood and plasma donors

Whole blood donors, especially frequently donating donors, have a risk of iron deficiency and low hemoglobin levels, which may affect their health and eligibility to donate. Lifestyle behaviors, such as dietary iron intake and physical activity, may influence iron stores and thereby hemoglobin levels. We aimed to investigate whether dietary iron intake and questionnaire-based moderate-to-vigorous physical activity were associated with hemoglobin levels, and whether ferritin levels mediated these associations. In Donor InSight-III, a Dutch cohort study of blood and plasma donors, data on heme and non-heme iron intake (mg/day), moderate-to-vigorous physical activity (10 minutes/day), hemoglobin levels (mmol/L) and ferritin levels (μg/L) were available in 2,323 donors (1,074 male). Donors with higher heme iron intakes (regression coefficients (β) in men and women: 0.160 and 0.065 mmol/L higher hemoglobin per 1 mg of heme iron, respectively) and lower non-heme iron intakes (β: -0.014 and -0.017, respectively) had higher hemoglobin levels, adjusted for relevant confounders. Ferritin levels mediated these associations (indirect effect (95% confidence interval) in men and women respectively: 0.074 (0.045; 0.111) and 0.061 (0.030; 0.096) for heme and -0.003 (-0.008;0.001) and -0.008 (-0.013;-0.003) for non-heme). Moderate-to-vigorous physical activity was negatively associated with hemoglobin levels in men only (β: -0.005), but not mediated by ferritin levels. In conclusion, higher heme and lower non-heme iron intake were associated with higher hemoglobin levels in donors, via higher ferritin levels. This indicates that donors with high heme iron intake may be more capable of maintaining iron stores to recover hemoglobin levels after blood donation.

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“…Details of DIS-III have been described elsewhere and information about Hb trajectories is available in the Online Supplementary Methods . 32 …”

Section: Methodsmentioning

confidence: 99%

Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight

et al. 2019

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“…DIS is a Dutch cohort study of blood and plasma donors carried out by Sanquin—the only organization in the Netherlands authorized to collect blood from donors [32]. The wide geographical distribution of Sanquin’s blood collection centers across the Netherlands and the large number of blood donors involved in the study yield data that allows us to explore the association of population density on lifestyle behaviors and blood lipid levels.…”

Section: Methodsmentioning

confidence: 99%

The association between population density and blood lipid levels in Dutch blood donors

et al. 2019

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BackgroundIn low and middle-income countries (LMIC), the total and LDL cholesterol and triglyceride levels of residents of urban areas are reported to be higher than those of rural areas. This may be due to differences in lifestyle behaviors between residents of urban areas and rural areas in LMIC. In this study, our aims were to (1) examine whether or not LDL cholesterol, total/HDL ratios and triglyceride levels of individuals in densely populated areas are higher than those of individuals living in less-densely populated areas in a high-income country (HIC) and (2) investigate the potential mediating roles of physical activity and sedentary behavior.MethodsWe used cross-sectional data from 2547 Dutch blood donors that participated in Donor InSight-III. Linear regression was used to analyze the association between population density and LDL cholesterol, total/HDL cholesterol ratio and HDL cholesterol. The mediating roles of moderate-to-vigorous physical activity (MVPA) and sedentary behavior were investigated in a subsample (n = 740) for which objectively measured MVPA/sedentary behavior data was available. Multiple mediation with linear regression analyses were performed and the product-of-coefficients method was used to calculate direct and indirect effects.ResultsMean LDL cholesterol and median total cholesterol/HDL cholesterol ratio and triglyceride levels were 2.89, 3.43 and 1.29 mmol/L, respectively. Population density was not associated with LDL cholesterol [β 0.00 (− 0.01; 0.01)], log transformed total/HDL cholesterol ratio [β 1.00 (1.00; 1.00)] and triglyceride levels [β 1.00 (0.99; 1.00)]. No statistically significant direct or indirect effects were found.ConclusionContrary to previous findings in LMIC, no evidence was found that population density is associated with blood lipid levels in blood donors in the Netherlands or that MVPA and sedentary behavior mediate this association. This may be the result of socioeconomic differences and, in part, may be due to the good health of the study population and the relatively high population density in the Netherlands. Also, compared to LMIC, differences in physical activity levels in more versus less populated areas may be less pronounced in HIC.Electronic supplementary materialThe online version of this article (10.1186/s12942-019-0167-y) contains supplementary material, which is available to authorized users.

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“…This sample bank was then used to investigate the prevalence of HIV‐1, HIV‐2, human T‐cell lymphotropic virus type I (HTLV‐I) and type II (HTLV‐II) seropositivity in first‐time blood donors, ascertain associated risk factors and observe the subsequent rate of seroconversion in repeat donors over time as a measure of infection incidence. Blood donor‐based biobanks have also been established in Germany , the UK , the Netherlands , Denmark , Italy and Japan and it is claimed over 200 publications in the peer‐reviewed scientific literature have resulted from such repositories . To date, these studies have mainly investigated questions related to transfusion safety such as the epidemiology and detection of TTIs , donation‐related physical symptoms and iron‐deficiency anaemia .…”

Section: Principles Of Information Disclosurementioning

confidence: 99%

“…A 2008 survey of blood services in fifteen countries revealed that operational archiving of donor specimens was usually limited to serum or plasma; however, DNA extraction was described for selected purposes, such as donors with rare red cell antigens. Subsequently, DNA isolation from blood donors specifically for the purpose of research biobanking has been described . Public opinion surveys have indicated that donors themselves are largely supportive of the contribution of their blood donation to research biobanks, even for identity‐linked genetic research …”

Section: Principles Of Information Disclosurementioning

confidence: 99%

Informed consent for whole blood donation

Grainger

Flanagan

2019

Vox Sanguinis

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Background and objectives It is recognized that blood transfusion services have an ethical duty to obtain informed consent from their voluntary, non-remunerated donors. This right was most recently affirmed by the 2017 revision of the International Society of Blood Transfusion (ISBT) Code of Ethics. However, the constituent elements necessary to adequately inform such consent have not been definitively established. Materials and methodsThis review evaluates the historical background to informed consent in medicine and as it has been applied to blood donation. The question of what information should be disclosed is then considered with regard to existing statutory requirements in both the United States and EU as well guidance from relevant international organizations. The emerging ethical issues around repurposing of donated blood for sale as recovered plasma and use in research are included in this analysis.Results A reasonable basis is found in the literature to advocate that valid informed consent of blood donors should encompass: the donation process itself and potential adverse effects, the need for pre-donation transfusion-transmissible infection (TTI) screening, potential non-transfusion uses of derived products, requirements to obtain and store personal information, the consequences that non-disclosure of such information may have for both the donor and the recipient and reassurance as to the confidentiality of this information.Conclusion Informed consent is a key component of the duty of care between a blood service and its donor. We identify essential elements that should be present for such consent to be considered valid.

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Donor InSight: characteristics and representativeness of a Dutch cohort study on blood and plasma donors

Cited by 31 publications

References 26 publications

Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight

Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight

The association between population density and blood lipid levels in Dutch blood donors

Informed consent for whole blood donation

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