Donor Klotho KL-VS Polymorphism Predicts Allograft Glomerulosclerosis and Early Post-Transplant Kidney Function

Pazik, J.; Rembek, Karolina; Sadowska-Jakubowicz, Anna; Sitarek, E; Kosieradzki, Maciej; Durlik, Magdalena

doi:10.1016/j.transproceed.2020.02.086

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Deceased donor Klotho polymorphism, also predicts early transplant glomerular lesions and function [43]. While Klotho levels of the recipient and donor before transplantation may be significant, Klotho levels measured after transplantation are not associated with decline of renal function in our cohort.…”

Section: Discussionmentioning

confidence: 60%

“…Indeed, the pre-transplant Klotho level seems to be decisive for the post-transplant period, independent of transplant or donor characteristics [ 42 ]. Deceased donor Klotho polymorphism, also predicts early transplant glomerular lesions and function [ 43 ]. While Klotho levels of the recipient and donor before transplantation may be significant, Klotho levels measured after transplantation are not associated with decline of renal function in our cohort.…”

Section: Discussionmentioning

confidence: 99%

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Calcification Propensity (T50) Predicts a Rapid Decline of Renal Function in Kidney Transplant Recipients

Hammer

Legouis

Huber

et al. 2023

JCM

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Background: Serum creatinine level, proteinuria, and interstitial fibrosis are predictive of renal prognosis. Fractional excretion of phosphate (FEP)/FGF23 ratio, tubular reabsorption of phosphate (TRP), serum calcification propensity (T50), and Klotho’s serum level are emerging as determinants of poor kidney outcomes in CKD patients. We aimed at analysing the use of FGF23, FEP/FGF23, TRP, T50, and Klotho in predicting the rapid decline of renal function in kidney allograft recipients. Methods: We included 103 kidney allograft recipients in a retrospective study with a prospective follow-up of 4 years. We analysed the predictive values of FGF23, FEP/FGF23, TRP, T50, and Klotho for a rapid decline of renal function defined as a drop of eGFR > 30%. Results: During a follow-up of 4 years, 23 patients displayed a rapid decline of renal function. Tertile of FGF23 (p value = 0.17), FEP/FGF23 (p value = 0.78), TRP (p value = 0.62) and Klotho (p value = 0.31) were not associated with an increased risk of rapid decline of renal function in kidney transplant recipients. The lower tertile of T50 was significantly associated with eGFR decline >30% with a hazard ratio of 3.86 (p = 0.048) and remained significant in multivariable analysis. Conclusion: T50 showed a strong association with a rapid decline of renal function in kidney allograft patients. This study underlines its role as an independent biomarker of loss of kidney function. We found no association between other phosphocalcic markers, such as FGF23, FEP/FGF23, TRP and Klotho, with a rapid decline of renal function in kidney allograft recipients.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Calcification Propensity (T50) Predicts a Rapid Decline of Renal Function in Kidney Transplant Recipients

Hammer

Legouis

Huber

et al. 2023

JCM

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“…90 In peritransplant biopsy specimens from 170 deceased donors, a chronic glomerulopathy score >0 was more frequent in KL-VS carriers (12.2% versus 3.2%; P = 0.023). 91 Moreover, the incidence of proteinuria was higher and eGFR lower at 3 mo in recipients of KL-VS allografts. These results point to KL-VS genotype as a tool to predict early kidney graft impairment.…”

Section: Klotho and Outcomes In Ktmentioning

confidence: 96%

The Value of Klotho in Kidney Transplantation

et al. 2022

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Kidney transplant recipients have better survival rates and improved quality of life than long-term dialysis patients. However, delayed graft function, immunosuppressive therapy nephrotoxicity, and rejection episodes may compromise graft and patient survival. The KL gene is highly expressed in kidney tubular cells and encodes the antiaging and kidney-protective protein Klotho, which has membrane-anchored and soluble forms and regulates mineral metabolism. Klotho expression decreases during acute kidney injury or chronic kidney disease, and human chronic kidney disease shares features of accelerated aging with murine Klotho deficiency. In this work, we review clinical studies on the relationship between Klotho and kidney transplantation. Specifically, we address the dynamics of serum and kidney Klotho levels in donors and kidney transplant recipients, the role of Klotho as a marker of current graft function and graft outcomes, and the potential impact of Klotho on kidney protection in the transplantation context. A better understanding of the potential biomarker and therapeutic utility of Klotho in kidney transplant recipients may provide new insights into the control of graft function and new therapeutic strategies to preserve allograft function.

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Association of KLOTHO gene variants with metabolic and renal function parameters in Mexican patients living with type 2 diabetes

Mendoza-Carrera,

Farías-Basulto,

Gómez-García

et al. 2024

J Diabetes Metab Disord

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Donor Klotho KL-VS Polymorphism Predicts Allograft Glomerulosclerosis and Early Post-Transplant Kidney Function

Cited by 3 publications

References 17 publications

Calcification Propensity (T50) Predicts a Rapid Decline of Renal Function in Kidney Transplant Recipients

Calcification Propensity (T50) Predicts a Rapid Decline of Renal Function in Kidney Transplant Recipients

The Value of Klotho in Kidney Transplantation

Association of KLOTHO gene variants with metabolic and renal function parameters in Mexican patients living with type 2 diabetes

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