Donor Preconditioning with Taurine Protects Kidney Grafts from Injury After Experimental Transplantation

Guan, Xiaohai; Dei-Anane, Genevieve; Liang, Rui; Groß, Marie-Luise; Nickkholgh, Arash; Kern, Michael; Ludwig, Jochen; Zeier, Martin; Büchler, Markus W.; Schmidt, Jan; Schemmer, Peter

doi:10.1016/j.jss.2007.06.014

Cited by 30 publications

(24 citation statements)

References 27 publications

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“…Recent studies suggest that during kidney injury, transcriptional repression of the taurine transporter by p53 determines intracellular depletion of taurine, causing necrotic cell death [49]. On the other hand, taurine supplementation protects mesangial and tubular cells from high glucose or hypoxia in vitro , ameliorates nephrotic syndrome or diabetic nephropathy in vivo in animal models [31], and provides better outcomes in patients transplanted with kidneys from donors submitted to taurine preconditioning [50]. T3 patients also displayed intra-graft reduction in choline, a pivotal factor for the synthesis of cell membranes and cell-signaling components, a condition that can translate to acute renal failure and hypertension in animal models [51].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Profiling in Individuals with a Failing Kidney Allograft

et al. 2017

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BackgroundAlteration of certain metabolites may play a role in the pathophysiology of renal allograft disease.MethodsTo explore metabolomic abnormalities in individuals with a failing kidney allograft, we analyzed by liquid chromatography-mass spectrometry (LC-MS/MS; for ex vivo profiling of serum and urine) and two dimensional correlated spectroscopy (2D COSY; for in vivo study of the kidney graft) 40 subjects with varying degrees of chronic allograft dysfunction stratified by tertiles of glomerular filtration rate (GFR; T1, T2, T3). Ten healthy non-allograft individuals were chosen as controls.ResultsLC-MS/MS analysis revealed a dose-response association between GFR and serum concentration of tryptophan, glutamine, dimethylarginine isomers (asymmetric [A]DMA and symmetric [S]DMA) and short-chain acylcarnitines (C4 and C12), (test for trend: T1-T3 = p<0.05; p = 0.01; p<0.001; p = 0.01; p = 0.01; p<0.05, respectively). The same association was found between GFR and urinary levels of histidine, DOPA, dopamine, carnosine, SDMA and ADMA (test for trend: T1-T3 = p<0.05; p<0.01; p = 0.001; p<0.05; p = 0.001; p<0.001; p<0.01, respectively). In vivo 2D COSY of the kidney allograft revealed significant reduction in the parenchymal content of choline, creatine, taurine and threonine (all: p<0.05) in individuals with lower GFR levels.ConclusionsWe report an association between renal function and altered metabolomic profile in renal transplant individuals with different degrees of kidney graft function.

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Section: Discussionmentioning

confidence: 99%

Metabolomic Profiling in Individuals with a Failing Kidney Allograft

et al. 2017

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“…Taurine, a sulfur-containing β-amino acid and also a major free intracellular amino acid in mammalian cells (Kerai et al, 1999), is well known as an endogenous anti-oxidant and membrane-stabilizing agent. Many studies have documented the protective effects of taurine against multiple types of kidney damage, including ischemia/reperfusion, hyperglycemia, oxidantstress and xenobiotics (Al-Kahtani, 2010;Guan et al, 2008). In addition, taurine treatment can alleviate the tubular oxidative injury via a mitochondrial-linked pathway in rat models of nephrolithiasis ).…”

Section: Discussionmentioning

confidence: 99%

Urinary metabonomics elucidate the therapeutic mechanism of Orthosiphon stamineus in mouse crystal-induced kidney injury

Gao

Chen

Peng

et al. 2015

Journal of Ethnopharmacology

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“…A more recent study examined the impact of taurine preconditioning of the rat donor kidney; taurine preconditioning was achieved by treatment of the rat for 19 hrs. with taurine prior to donor nephrectomy [30]. Following transplantation, the taurine preconditioned kidney was resistant to injury (apoptosis and necrosis) relative to the untreated kidney.…”

Section: Discussionmentioning

confidence: 99%

Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injury

et al. 2010

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Taurine possesses membrane stabilization, osmoregulatory and antioxidant properties, aspects of relevance to ischemic injury. We tested the hypothesis that body taurine status is a determinant of renal ischemic injury. Accordingly, renal function and structure were examined in control (C), taurine-treated (TT) and taurine deficient (TD) rats that were subjected to bilateral renal ischemia (60 min) followed by reperfusion (IR); sham operated rats served as controls. Baseline urine osmolality was greater in the TD group than in the control and the TT groups, an effect associated with increased renal aquaporin 2 level. The IR insult reduced urine osmolality (i.e., day-1 post insult); the TD/IR group displayed a more marked recovery in urine osmolality by day-6 post insult than the other two groups. Fluid and sodium excretions were lower in the TD/IR group, suggesting propensity to retention. Histopathological examination revealed the presence of tubular necrotic foci in the C/IR group than sham controls. While renal architecture of the TD/IR group showed features resembling sham controls, the TT/IR group showed dilated tubules, which lacked immunostaining for aquaporin 2, but not 1, suggestive of proximal tubule origin. Finally, assessment of cell proliferation and apoptosis revealed lower proliferation but higher apoptotic foci in the TT/IR group than other IR groups. Collectively, the results indicate that body taurine status is a major determinant of renal IR injury.

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Donor Preconditioning with Taurine Protects Kidney Grafts from Injury After Experimental Transplantation

Cited by 30 publications

References 27 publications

Metabolomic Profiling in Individuals with a Failing Kidney Allograft

Metabolomic Profiling in Individuals with a Failing Kidney Allograft

Urinary metabonomics elucidate the therapeutic mechanism of Orthosiphon stamineus in mouse crystal-induced kidney injury

Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injury

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