Dopamine agonist treatment increases sensitivity to gamble outcomes in the hippocampus in de novo Parkinson’s disease

Vegt, J.P.M. van der; Hulme, Oliver J.; Madsen, Kristoffer Hougaard; Buhmann, Carsten; Bloem, Bastiaan R.; Münchau, Alexander; Helmich, Rick C.; Siebner, Hartwig R.

doi:10.1016/j.nicl.2020.102362

Cited by 1 publication

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“…Furthermore, the underlying involvement of visual illusions include not only the primary visual cortex and surrounding regions, but also the hippocampus [ 119 ]. Finally, dopamine depletion is also linked to attenuated reward signaling in the mesolimbic system, and deficient reward-related processing in the hippocampus has been shown to be partially restorable through the administration of dopaminergic medication [ 120 ].…”

Section: Regions Of the Limbic Systemmentioning

confidence: 99%

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

et al. 2022

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The limbic system describes a complex of brain structures central for memory, learning, as well as goal directed and emotional behavior. In addition to pathological studies, recent findings using in vivo structural and functional imaging of the brain pinpoint the vulnerability of limbic structures to neurodegeneration in Parkinson’s disease (PD) throughout the disease course. Accordingly, dysfunction of the limbic system is critically related to the symptom complex which characterizes PD, including neuropsychiatric, vegetative, and motor symptoms, and their heterogeneity in patients with PD. The aim of this systematic review was to put the spotlight on neuroimaging of the limbic system in PD and to give an overview of the most important structures affected by the disease, their function, disease related alterations, and corresponding clinical manifestations. PubMed was searched in order to identify the most recent studies that investigate the limbic system in PD with the help of neuroimaging methods. First, PD related neuropathological changes and corresponding clinical symptoms of each limbic system region are reviewed, and, finally, a network integration of the limbic system within the complex of PD pathology is discussed.

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Section: Regions Of the Limbic Systemmentioning

confidence: 99%