Dopamine based adhesive nano-coatings on extracellular matrix (ECM) based grafts for enhanced host–graft interfacing affinity

Tao, Chao; Jin, Min; Hui-yuan, Yao; Wang, Dong‐An

doi:10.1039/d1nr06284k

Cited by 14 publications

(5 citation statements)

References 65 publications

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“…Adhesion and integration of implanted materials with native tissue are important in cartilage tissue repair because insufficient adhesion and integration challenge implant stability and the ability of cells to migrate across a mechanically unstable gap [ 25 , 26 ]. Previously reported strategies using sutures, glue pretreatment, or implant surface modification techniques to improve graft–host bonding have shown dissatisfactory results, even impairing the healing [ 25 , 26 , 27 ]. However, GelMA/SF composite hydrogels exhibit unique tissue adhesion capabilities that facilitate integration; for example, in treating corneal perforations [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

BMSCs-Seeded Interpenetrating Network GelMA/SF Composite Hydrogel for Articular Cartilage Repair

Zheng

et al. 2023

JFB

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Because of limited self-healing ability, the treatment of articular cartilage defects is still an important clinical challenge. Hydrogel-based biomaterials have broad application prospects in articular cartilage repair. In this study, gelatin methacrylate (GelMA)and silk fibroin (SF) were combined to form a composite hydrogel with an interpenetrating network (IPN) structure under ultraviolet irradiation and ethanol treatment. Introducing silk fibroin into GelMA hydrogel significantly increased mechanical strength as compressive modulus reached 300 kPa in a GelMA/SF-5 (50 mg/mL silk fibroin) group. Moreover, composite IPN hydrogels demonstrated reduced swelling ratios and favorable biocompatibility and supported chondrogenesis of bone mesenchymal stem cells (BMSCs) at day 7 and day 14. Additionally, significantly higher gene expressions of Col-2, Acan, and Sox-9 (p < 0.01) were found in IPN hydrogel groups when compared with the GelMA group. An in vivo study was performed to confirm that the GelMA-SF IPN hydrogel could promote cartilage regeneration. The results showed partial regeneration of cartilage in groups treated with hydrogels only and satisfactory cartilage repair in groups of cell-seeded hydrogels, indicating the necessity of additional seeding cells in hydro-gel-based cartilage treatment. Therefore, our results suggest that the GelMA/SF IPN hydrogels may be a potential functional material in cartilage repair and regeneration.

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Section: Discussionmentioning

confidence: 99%

BMSCs-Seeded Interpenetrating Network GelMA/SF Composite Hydrogel for Articular Cartilage Repair

Zheng

et al. 2023

JFB

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“…In another study [ 79 ], albumin was rapidly crosslinked with NHS ester-functionalized PEG via a reaction between the negative charges of albumin and NHS esters of PEG through curing for 15–30 s, achieving an adequate strength within 2 min. Albumin adhesive was also prepared via a reaction between an albumin prepolymer, which was obtained through a reaction of albumin and citrate acid via EDC/NHS chemistry, and dopamine [ 85 ]. Similarly, an albumin adhesive was prepared via a reaction of albumin with genipin as a natural crosslinker in a water bath at 35℃ for 24 h without further purification [ 86 ].…”

Section: Representative Examples Of Polymeric Tasmentioning

confidence: 99%

Progress of tissue adhesives based on proteins and synthetic polymers

et al. 2023

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In recent years, polymer-based tissue adhesives (TAs) have been developed as an alternative to sutures to close and seal incisions or wounds owing to their ease of use, rapid application time, low cost, and minimal tissue damage. Although significant research is being conducted to develop new TAs with improved performances using different strategies, the applications of TAs are limited by several factors, such as weak adhesion strength and poor mechanical properties. Therefore, the next-generation advanced TAs with biomimetic and multifunctional properties should be developed. Herein, we review the requirements, adhesive performances, characteristics, adhesive mechanisms, applications, commercial products, and advantages and disadvantages of proteins- and synthetic polymer-based TAs. Furthermore, future perspectives in the field of TA-based research have been discussed.

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“…In this study, chondroitin sulfate (CS) was introduced as a negatively charged polysaccharide, which is a glycosaminoglycan (GAG) derived from cartilage, has been proven to be an effective biocompatible base material of bio-adhesives for both hemostasis and integration extracellular matrix based porous grafts. [17][18][19] Correspondingly, branched polyethylenimine (PEI) was introduced as a positively charged polymer, which has been widely investigated in applications of gene therapy, antimicrobial as well as bioadhesives. [20][21][22] As for surface adhesion, mussel-inspired chemistry can provide hints, and the most critical catechol groups, which can polymerize or oxidize under an alkaline environment, have been intensively studied for bio-adhesives.…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25] Our group has developed mussel-inspired bio-adhesives using dopamine with catechol groups for adhesion. [17,18,26,27] Catechin (CC) is mainly sourced from plants, has been widely studied as an antioxidant with catechol groups, [28,29] but less reported in bioadhesives. [30,31] Herein, the basic design spirit of this study was as follows.…”

Section: Introductionmentioning

confidence: 99%

An Instant Underwater Tissue Adhesive Composed of Catechin‐Chondroitin Sulfate and Cholesterol‐Polyethyleneimine

Jin

Tao

et al. 2023

Adv Healthcare Materials

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Due to the safety issue and poor underwater adhesion of current commercially available bioadhesives, they are hard to apply to in vivo physiological environments and more diverse medical use conditions. In this study, a novel and facile bioadhesive for underwater medical applications are designed based on the coacervation of electrostatic interactions and hydrophobic interactions, with the introduction of catechin as a provider of catechol moieties for adhesion to surrounding tissues. The orange‐colored bio‐adhesive, named PcC, is generated within seconds by mixing catechin‐modified chondroitin sulfate and cholesterol chloroformate‐modified polyethyleneimine with agitation. In vitro mechanical measurements prove that this novel PcC bio‐adhesive is superior in underwater adhesion performance when applied to cartilage. Animal experiments in a rat mastectomy model and rat cartilage graft implantation model demonstrate its potential for diverse medical purposes, such as closing surgical incisions, reducing the formation of seroma, and tissue adhesive applied in orthopedic or cartilage surgery.

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Dopamine based adhesive nano-coatings on extracellular matrix (ECM) based grafts for enhanced host–graft interfacing affinity

Abstract: Interfacing affinity between grafts and host tissues is an urgent issue that needs to be addressed for clinical translation of tissue engineered extracellular matrix (ECM) based grafts. Dopamine is known...

Cited by 14 publications

References 65 publications

BMSCs-Seeded Interpenetrating Network GelMA/SF Composite Hydrogel for Articular Cartilage Repair

BMSCs-Seeded Interpenetrating Network GelMA/SF Composite Hydrogel for Articular Cartilage Repair

Progress of tissue adhesives based on proteins and synthetic polymers

An Instant Underwater Tissue Adhesive Composed of Catechin‐Chondroitin Sulfate and Cholesterol‐Polyethyleneimine

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