Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex

Pezze, Marie A.; Marshall, Hayley J.; Fone, Kevin C. F.; Cassaday, Helen J.

doi:10.1016/j.euroneuro.2015.07.018

Cited by 49 publications

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“…into the mPFC induced a dose-related impairment in object recognition encoding and retrieval (Pezze et al, 2015). Although these results appear conflicting, the authors propose that NOR memory requires an optimal level of D 1 receptor stimulation in the mPFC and may reflect an inverted U-shaped function (Pezze et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: A preliminary investigation

et al. 2017

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Rationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and is a thoroughly validated animal model for cognitive deficits in schizophrenia. The aim of our study was to investigate the role of PFC dopamine in scPCP-induced deficits in a cognitive task of relevance to the disorder, novel object recognition (NOR). Methods: Twelve adult female Lister Hooded rats received scPCP (2 mg/kg) or vehicle via the intraperitoneal route twice daily for seven days, followed by seven days washout. In vivo microdialysis was carried out prior to, during and following the NOR task. Results: Vehicle rats successfully discriminated between novel and familiar objects and this was accompanied by a significant increase in dopamine in the PFC during the retention trial (P<0.01). scPCP produced a significant deficit in NOR (P<0.05 vs. control) and no PFC dopamine increase was observed. Conclusions: These data demonstrate an increase in dopamine during the retention trial in vehicle rats that was not observed in scPCP-treated rats accompanied by cognitive disruption in the scPCP group. This novel finding suggests a mechanism by which cognitive deficits are produced in this animal model and support its use for investigating disorders in which PFC dopamine is central to the pathophysiology.3

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Section: Discussionmentioning

confidence: 99%

“…Although these results appear conflicting, the authors propose that NOR memory requires an optimal level of D 1 receptor stimulation in the mPFC and may reflect an inverted U-shaped function (Pezze et al, 2015). The role of dopamine in the PFC has been further investigated using other selective dopamine receptor agonists and antagonists.…”

Section: Discussionmentioning

confidence: 99%

Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: A preliminary investigation

et al. 2017

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“…As this is an innate tendency, novel object recognition (NOR) procedures offer advantages over many learning and memory tasks in that NOR can be studied without training or the use of positive (e.g., food) or negative (e.g., footshock) reinforcers (Lyon et al 2012). Furthermore, by selecting an appropriate phase for drug administration, the task can be utilized to distinguish the effects of neuropharmacological manipulations on acquisition, consolidation, and/or retrieval of visual learning and memory (King et al 2004;Pezze et al 2015). The neurobiological substrates of recognition memory have been extensively studied (Winters et al 2008;Brown et al 2010;Warburton and Brown 2010) and a key role has been identified for plasticity within the perirhinal cortex (Bussey et al 1999;Brown and Aggleton 2001;Banks et al 2012).…”

Section: United Kingdommentioning

confidence: 99%

“…The NOR task was based on previously established protocol (Pezze et al 2015). Experiments 1 and 2 were run over a 6 d cycle in a within-subjects design.…”

Section: Nor: Behavioral Proceduresmentioning

confidence: 99%

Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay

et al. 2017

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Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesion studies cannot distinguish effects on encoding and retrieval. The interval between encoding and retrieval tests may also be a critical determinant of the role of the ACgx. The current series of experiments used micro-infusion of the GABAA receptor agonist, muscimol, into ACgx to reversibly inactivate the area and distinguish its role in encoding and retrieval. ACgx infusions of muscimol, before encoding did not alter NOR assessed after a delay of 20 min or 24 h. However, when infused into the ACgx before retrieval muscimol impaired NOR assessed after a delay of 24 h, but not after a 20-min retention test. Together these findings suggest that the ACgx plays a time-dependent role in the retrieval, but not the encoding, of NOR memory, neuronal activation being required for the retrieval of remote (24 h old), but not recent (20 min old) visual memory.

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“…IP injection of SCH-23390 [11], or by D1 activity facilitation via SKF81297 microinfusion in the prefrontal cortex [12].…”

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Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice

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Muratori

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et al. 2016

Behavioural Brain Research

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h i g h l i g h t s• Heterozygous mice for dopamine transporter (DAT+/−) exhibit higher levels of synaptic dopamine.• Here we confirmed that D2 antagonism can interfere in object recognition.• We observed in DAT+/− a natural phenotype of impaired novel object memory recognition.• The injection of haloperidol at 0.05 mg before object exposition restored object recognition.• This effect could be explained by restoring D2 activity to optimal levels, acting on memory acquisition. a r t i c l e i n f o Genetically-modified mice without the dopamine transporter (DAT) are hyperdopaminergic, and serve as models for studies of addiction, mania and hyperactive disorders. Here we investigated the capacity for object recognition in mildly hyperdopaminergic mice heterozygous for DAT (DAT +/−), with synaptic dopaminergic levels situated between those shown by DAT −/− homozygous and wild-type (WT) mice. We used a classical dopamine D2 antagonist, haloperidol, to modulate the levels of dopaminergic transmission in a dose-dependent manner, before or after exploring novel objects. In comparison with WT mice, DAT +/− mice showed a deficit in object recognition upon subsequent testing 24 h later. This deficit was compensated by a single 0.05 mg/kg haloperidol injection 30 min before training. In all mice, a 0.3 mg/kg haloperidol injected immediately after training impaired object recognition. The results indicate that a mild enhancement of dopaminergic levels can be detrimental to object recognition, and that this deficit can be rescued by a low dose of a D2 dopamine receptor antagonist. This suggests that novel object recognition is optimal at intermediate levels of D2 receptor activity.© 2016 Elsevier B.V. All rights reserved.Dopamine (DA) is a neurotransmitter related to complex behaviors, such as: reward perception, social interaction [1,2], and is also linked to memory consolidation both in humans and rodents [3]. Alterations in DA synaptic regulation are related to a large variety of mental diseases, such as schizophrenia, hyperactivity, mood disorders, and Parkinson disease [4,5]. * Corresponding author.E-mail addresses: brunolobaosoares@gmail.com, brunolobaosoares@hotmail.com (B. Lobão-Soares).DA has many receptor subtypes, but they are basically divided in D1 and D2 families [3]. DA, mainly through D1 receptors, elicits the onset of the late phase of long term potentiation in the hippocampus [6], control plasticity-induced protein synthesis [6], and enhance the persistence of hippocampus-dependent memories [7].The involvement of both dopamine receptors families with learning and memory is widely reported for working memory [3], spatial learning [3,6], aversive memory [7], reward-related learning [8] and cognitive flexibility [9]. In particular, impairment in object recognition has been induced by D2 activity suppression due to haloperidol IP injection [10], by D1 activity suppression trough http://dx

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Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex

Cited by 49 publications

References 49 publications

Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: A preliminary investigation

Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: A preliminary investigation

Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay

Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice

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