Dopamine differentially modulates medial temporal lobe activity and behavior during spatial navigation in young and older adults

Baeuchl, Christian; Glöckner, Franka; Petzold, Johannes; Smolka, Michael N.; Li, Shu-Chen

doi:10.1016/j.neuroimage.2023.120099

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Cited by 3 publications

References 99 publications

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Beta oscillation modulations of the orienting attention network effect correlate with dopamine-dependent motor symptoms of Parkinson’s disease

Jiang,

Ding,

Chen

et al. 2024

Brain Struct Funct

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Beta oscillation modulations of the orienting attention network effect correlate with dopamine-dependent motor symptoms of Parkinson’s disease

Jiang,

Ding,

Chen

et al. 2024

Brain Struct Funct

View full text Add to dashboard Cite

Interactions between memory and reward systems

Poh,

Adcock

2024

Reference Module in Neuroscience and Biobehavioral Psychology

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Levodopa suppresses grid-like activity and impairs spatial learning in novel environments in healthy young adults

Gönner,

Baeuchl,

Glöckner

et al. 2023

Cerebral Cortex

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Accumulated evidence from animal studies suggests a role for the neuromodulator dopamine in memory processes, particularly under conditions of novelty or reward. Our understanding of how dopaminergic modulation impacts spatial representations and spatial memory in humans remains limited. Recent evidence suggests age-specific regulation effects of dopamine pharmacology on activity in the medial temporal lobe, a key region for spatial memory. To which degree this modulation affects spatially patterned medial temporal representations remains unclear. We reanalyzed recent data from a pharmacological dopamine challenge during functional brain imaging combined with a virtual object-location memory paradigm to assess the effect of Levodopa, a dopamine precursor, on grid-like activity in the entorhinal cortex. We found that Levodopa impaired grid cell-like representations in a sample of young adults (n = 55, age = 26–35 years) in a novel environment, accompanied by reduced spatial memory performance. We observed no such impairment when Levodopa was delivered to participants who had prior experience with the task. These results are consistent with a role of dopamine in modulating the encoding of novel spatial experiences. Our results suggest that dopamine signaling may play a larger role in shaping ongoing spatial representations than previously thought.

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Dopamine differentially modulates medial temporal lobe activity and behavior during spatial navigation in young and older adults

Cited by 3 publications

References 99 publications

Beta oscillation modulations of the orienting attention network effect correlate with dopamine-dependent motor symptoms of Parkinson’s disease

Beta oscillation modulations of the orienting attention network effect correlate with dopamine-dependent motor symptoms of Parkinson’s disease

Interactions between memory and reward systems

Levodopa suppresses grid-like activity and impairs spatial learning in novel environments in healthy young adults

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