Dopamine Effects on Human Error Processing Depend on Catechol-<i>O</i>-Methyltransferase VAL158MET Genotype

Mueller, Erik M.; Makeig, Scott; Stemmler, Gerhard; Hennig, Jürgen; Wacker, Jan

doi:10.1523/jneurosci.2103-11.2011

Cited by 55 publications

(59 citation statements)

References 64 publications

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“…In particular, although in our task participants could not directly infer from behavior whether it is correct or incorrect, actions assessed by the strict evaluator induced a similar electrocortical responses as have previously been reported for clear behavioral errors (i.e., actions that were wrong in terms of an explicit task rule; e.g. Luu et al, 2004;Mueller, Makeig, Stemmler, Hennig, & Wacker, 2011;Trujillo & Allen, 2007). This does not necessarily mean that performance in the strict evaluator context has been rather assessed as false by the system.…”

Section: Task Performance Stagesupporting

confidence: 52%

Face-induced expectancies influence neural mechanisms of performance monitoring

Osinsky

Seeger

Mussel

et al. 2015

Cogn Affect Behav Neurosci

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In many daily situations, the consequences of our actions are predicted by cues that are often social in nature. For instance, seeing the face of an evaluator (e.g., a supervisor at work) may activate certain evaluative expectancies, depending on the history of prior encounters with that particular person. We investigated how such face-induced expectancies influence neurocognitive functions of performance monitoring. We recorded an electroencephalogram while participants completed a time-estimation task, during which they received performance feedback from a strict and a lenient evaluator. During each trial, participants first saw the evaluator's face before performing the task and, finally, receiving feedback. Therefore, faces could be used as predictive cues for the upcoming evaluation. We analyzed electrocortical signatures of performance monitoring at the stages of cue processing, task performance, and feedback reception. Our results indicate that, at the cue stage, seeing the strict evaluator's face results in an anticipatory preparation of fronto-medial monitoring mechanisms, as reflected by a sustained negative-going amplitude shift (i.e., the contingent negative variation). At the performance stage, face-induced expectancies of a strict evaluation rule led to increases of early performance monitoring signals (i.e., frontal-midline theta power). At the final stage of feedback reception, violations of outcome expectancies differentially affected the feedback-related negativity and frontalmidline theta power, pointing to a functional dissociation between these signatures. Altogether, our results indicate that evaluative expectancies induced by face-cues lead to adjustments of internal performance monitoring mechanisms at various stages of task processing.

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Section: Task Performance Stagesupporting

confidence: 52%

Face-induced expectancies influence neural mechanisms of performance monitoring

Osinsky

Seeger

Mussel

et al. 2015

Cogn Affect Behav Neurosci

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“…In particular, there is evidence that ERN (and thus probably activity in the anterior MCC) can be reduced under antipsychotic medication. [56][57][58] As the majority of our clinical sample was treated with antipsychotic medication we cannot rule out that some of the results obtained in our study may have been influenced by effects of medication. Second, owing to the relative infrequency of errors in the compatible condition (i.e., low conflict trials) in patients with schizophrenia, only errors in the incompatible condition (i.e., high conflict trials) entered the analysis.…”

Section: Limitationsmentioning

confidence: 88%

Aberrant network connectivity during error processing in patients with schizophrenia

Voegler

Becker

Nitsch

et al. 2016

jpn

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“…EEG was recorded at 64 channels with a sampling rate of 512 Hz using an Active Two system (BioSemi, Amsterdam, Netherlands), as reported in more detail elsewhere (Mueller et al, 2011). ECG was measured with three Ag-AgCl flat electrodes in lead II configuration (right forearm, left leg, ground electrode on left arm) connected to the BioSemi system.…”

Section: Physiological Recordingmentioning

confidence: 99%

Panic Disorder and Serotonin Reuptake Inhibitors Predict Coupling of Cortical and Cardiac Activity

Mueller

Panitz

Nestoriuc

et al. 2013

Neuropsychopharmacol

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Panic attacks, the cardinal symptom of panic disorder (PD), are characterized by intense physiological reactions including accelerated heart activity. Although cortical processes are thought to trigger and potentiate panic attacks, it is unknown whether individuals with PD have a general tendency to show elevated cortico-cardiac interactions, which could predispose them for brain-driven modulations of heart activity during panic. Consistent with this hypothesis, serotonin, a highly relevant neurotransmitter for panic and PD presumably affects the cortical control of the heart. The current study thus aimed to test whether PD and serotonin reuptake inhibitor (SRI) intake are related to corticocardiac interactions in the absence of acute panic. Human participants with PD (n ¼ 22), major depression (MD, clinical control group, n ¼ 21) or no psychiatric diagnosis (healthy control group, n ¼ 23) performed a gambling task. To measure cortico-cardiac coupling, the within-subject covariation of single-trial EEG after feedback presentation and subsequent changes in heart period was determined. As in prior studies, there was a significant time-lagged covariation of EEG and heart activity indicating that trial-by-trial fluctuations of feedback-evoked EEG amplitude determined how much heart activity accelerated seconds later. Importantly, this covariation pattern was significantly potentiated in PD vs control participants. Moreover, concurrent SRI intake further augmented brain-heart covariation in individuals with PD and MD. The present findings demonstrate that PD and serotonin are associated with altered brain-heart interactions in a non-panic situation. Future work should clarify whether brain-heart coupling has a causal role in PD, for example by facilitating panic attacks.

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Dopamine Effects on Human Error Processing Depend on Catechol-O-Methyltransferase VAL158MET Genotype

Cited by 55 publications

References 64 publications

Face-induced expectancies influence neural mechanisms of performance monitoring

Face-induced expectancies influence neural mechanisms of performance monitoring

Aberrant network connectivity during error processing in patients with schizophrenia

Panic Disorder and Serotonin Reuptake Inhibitors Predict Coupling of Cortical and Cardiac Activity

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