Dopamine increases platelet intracellular calcium in bipolar affective disorder and controls

Berk, Michael; Bodemer, Wilhelm; Oudenhove, Tania Van; Butkow, Neil

doi:10.1097/00004850-199400940-00009

Cited by 27 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While dopamine receptors are expressed on the platelet, the platelet intracellular calcium response to dopamine has not been studied in schizophrenia. A single study in bipolar disorder failed to show any differentiation from controls (Berk et al, 1994). Serotonin is increasingly implicated in schizophrenia.…”

Section: Peripheral Markers Of Schizophreniamentioning

confidence: 93%

“…The 5HT 2 receptor is closely associated with the increase in intracellular calcium since blockade of 5HT 2 receptor sites by ketanserin, abolishes the augmented intracellular response (Kusumi, 1993;Mikuni et al, 1992). Noradrenaline does not cause an agonist-induced rise in platelet intracellular calcium (Mikuni et al, 1992;Berk et al, 1995), nor does dopamine (Berk et al, 1994).…”

Section: Studies Of Platelet Functionmentioning

confidence: 99%

See 1 more Smart Citation

The platelet as a peripheral marker in psychiatric illness

Plein

Berk

2001

Human Psychopharmacology

View full text Add to dashboard Cite

The identification of peripheral markers of psychiatric illness is important if an improvement in the diagnosis and treatment of various diseases with overlapping symptomatology is desired. There are many disorders that not only have overlapping symptomatology, but also have similar biological disturbances. The functional capability of the neurons involved in the disease processes may be at the crux of the underlying pathology. The platelet intracellular calcium response to neurotransmitter stimulation has previously been used as a peripheral marker of psychiatric illness. This review discusses evidence in support of the extended use of the platelet as a peripheral marker. The use of the platelet intracellular calcium response to neurotransmitter stimulation as a state or trait marker in major depression, the specificity and selectivity of this response, and the possible use of the platelet as a peripheral marker in psychotic disorders such as schizophrenia, mania and psychotic depression are shown. Finally, a proposed mechanism for the association between certain psychiatric disorders and cardiovascular disease is discussed. Copyright 2001 John Wiley& Sons, Ltd.

show abstract

Section: Peripheral Markers Of Schizophreniamentioning

confidence: 93%

Section: Studies Of Platelet Functionmentioning

confidence: 99%

The platelet as a peripheral marker in psychiatric illness

Plein

Berk

2001

Human Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Elevated basal calcium levels were found in platelets from unmedicated BPD patients who were either manic [227] or depressed [228]. Elevated calcium levels have also been found in euthymic BPD patients treated with lithium [229][230][231][232]. Other studies involving a mix of BPD patients have also found elevated basal platelet and lymphocyte calcium concentrations [233][234][235] and elevated B-lymphoblast calcium [236].…”

Section: Mdd + Dep Bpdmentioning

confidence: 99%

“…Other studies involving a mix of BPD patients have also found elevated basal platelet and lymphocyte calcium concentrations [233][234][235] and elevated B-lymphoblast calcium [236]. In contrast, however, there are also several reports of normal cellular calcium levels in manic BPD patients [229,230,237,238], depressed BPD patients [227,229,230,239,240], and in lithium-treated BPD patients [227,228,237,241,242].…”

Section: Mdd + Dep Bpdmentioning

confidence: 99%

Current Pathophysiological Findings in Bipolar Disorder and in its Subtypes

Silverstone¹,

McGrath²,

Wessels³

et al. 2005

CPSR

View full text Add to dashboard Cite

There have been many studies that have examined various aspects of the pathophysiology of bipolar disorder, with many positive findings in several areas of neuroimaging and metabolic abnormality. These studies might allow some conclusions to be drawn about the underlying pathophysiology. Additionally, it is of significant interest to determine if there are pathophysiological differences between patients with bipolar disorder type I (BPD-I) and those with bipolar disorder type II (BPD-II). The present review examines imaging studies in bipolar patients of possible structural changes (magnetic resonance imaging (MRI)) functional changes (focusing on functional MRI (fMRI), positron emission tomography (PET), and single photon emission computed tomography (SPECT)), and those examining brain chemistry (utilizing magnetic resonance spectroscopy (MRS)). Metabolic studies reviewed were those that examined 3-methoxy-4-hydroxyphenylglycol (MHPG), cellular calcium, and protein kinase C (PKC). The results clearly suggest that BPD patients differ from controls on many of these measures. However, while there is evidence from genetic studies suggesting possible differences between BPD-II patients and BPD-I patients, the neuroimaging and metabolic studies to date do not support this, and there appear to be no consistent pathophysiological differences between these subtypes from evidence available at present.

show abstract

“…Consequently, serotonin is the most widely studied neurotransmitter using platelet models, although norepinephrine, dopamine, adenosine and glutamate have also been researched. However, the similarities between noradrenergic and dopaminergic neurons and the platelet are much less compelling (3–6).…”

Section: Introductionmentioning

confidence: 99%

The platelet window: examining receptor regulated second messenger processes in psychosis and depression

Berk

Malhi

2003

Acta Neuropsychiatr.

View full text Add to dashboard Cite

Peripheral markers of psychiatric illness provide a potentially important window into the pathophysiology of a number of psychiatric illnesses. Direct access to pathophysiological processes is fraught with difficulty. However, receptor-regulated second messenger-mediated calcium shifts are an accessible and practical method by which to examine changes in a clinical population. This is possible because platelets and neurons share some physiological features. The platelet intracellular calcium response to receptor stimulation has previously been used as a peripheral marker of psychiatric illness across a range of neurotransmitters, including serotonin, dopamine and glutamate. This review considers the specificity and selectivity of this response and its use in psychotic and mood disorders.

show abstract

Dopamine increases platelet intracellular calcium in bipolar affective disorder and controls

Cited by 27 publications

References 0 publications

The platelet as a peripheral marker in psychiatric illness

The platelet as a peripheral marker in psychiatric illness

Current Pathophysiological Findings in Bipolar Disorder and in its Subtypes

The platelet window: examining receptor regulated second messenger processes in psychosis and depression

Contact Info

Product

Resources

About