Dopamine-Mediated Zwitterionic Polyelectrolyte-Coated Polypropylene Hernia Mesh with Synergistic Anti-inflammation Effects

Qiao, Yansha; Li, Yan; Zhang, Qian; Gao, Jing; Wang, Lu

doi:10.1021/acs.langmuir.0c00602

Cited by 40 publications

(37 citation statements)

References 56 publications

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“…This is the typical color of oxidant catechol, such as DA, after oxidized polymerization. 14 The existence of P and N elements in PMAD@TA/Fe-PP also implied the immobilization of PMAD on layer I and a stable cross-linked layer I at the same time. In summary, alkalicatalyzed oxidation was not only important for the stability of the assembled structure but also influenced PMAD immobilization.…”

Section: ■ Results and Discussionmentioning

confidence: 96%

“…PMAD, as the outer layer, always protects the intermediate layer of TA/Fe from oxidation, and catechol groups of PMAD also have antioxidant abilities. 14,39 Although there was a quick loss of antioxidant ability in the first 3 days, the property remained at 61.6% of the original value at 7 days, showing good antioxidant durability. The reason for the quick decrease in the first 3 days was supposedly the oxidation of surficial polyphenols of PMAD-TA/Fe and the loss of PMAD, but the second aryloxy radical coupling can be induced.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…18,19 To address this issue, we tried to introduce polydopamine (PDA) as the adhesive platform, and a synergistic anti-inflammatory coating was spontaneously obtained due to the antioxidant phenolic hydroxyl. 14 However, there were still some issues awaiting solutions: as the PDA coating was obtained via oxidative self-polymerization, poor controllability of deposition was the main drawback. 20,21 In addition, ZPs were loosely attached to PDA via noncovalent interactions (hydrogen bonds and electrostatic force), forming the outermost layer, which means that detachment of ZPs from substrate surfaces may occur under physiological conditions.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Therefore, the anti-inflammatory effects of natural biomaterials depend on many factors, such as source tissues and processing techniques. Hydrophilic synthetic polymers can be further classified into nonionic , and zwitterionic polymers. Poly(ethylene glycol) (PEG), a typical representative antifouling nonionic polymer, exhibits vulnerability to oxidative damage .…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, the strong antifouling ability of zwitterionic polymers (ZPs) has been confirmed to benefit from the overall zero net charge, , which shows significant potential in anti-inflammatory applications. However, in the covalent grafting methodologies of ZPs, “grafting to” or “grafting from” the substrate surface requires tricky or strict processes, such as reactive substrate surface preparation and oxygen-free environment creation. , To address this issue, we tried to introduce polydopamine (PDA) as the adhesive platform, and a synergistic anti-inflammatory coating was spontaneously obtained due to the antioxidant phenolic hydroxyl . However, there were still some issues awaiting solutions: as the PDA coating was obtained via oxidative self-polymerization, poor controllability of deposition was the main drawback. , In addition, ZPs were loosely attached to PDA via noncovalent interactions (hydrogen bonds and electrostatic force), forming the outermost layer, which means that detachment of ZPs from substrate surfaces may occur under physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Anti-inflammatory Coating “Zipped Up” on Polypropylene Hernia Mesh

Qiao

Zhang

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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Violent inflammation has impeded worry-free application of polypropylene (PP) hernia meshes. Efficient antiinflammatory coatings are urgently needed to alter the situation. Here, we present a zipper-like, two-layer coating with an intermediate antioxidant layer (I) and an outer antifouling layer (II) to endow PP meshes with synergistic anti-inflammatory effects. The controllable antioxidant ability of layer I was obtained by modulating the assembly cycle of the metal-phenolic network (MPN) composed of tannic acid (TA) and Fe 3+ . Polyzwitterionic (PMAD) brush-based layer II was generated upon multiple interactions between the catechol side groups of PMAD and layer I. To consolidate the entire assembly architecture, aryloxy radical coupling was initiated through alkali-catalyzed oxidation. The reaction is similar to a "zipping up" process to construct covalent bonds in the I−II interface and layer I by coupling adjacent catechol groups, which facilely achieved grafting and crosslinking. The obtained coating (PMAD-TA/Fe) did not affect the original properties of the PP mesh and remained stable during cyclic tensile testing or degradation. Most importantly, the excellent antioxidant and antifouling capacities enabled PMAD-TA/Fe-PP to exhibit desirable anti-inflammatory effects and reduce collagen deposition when compared with the bare material. The synergistic anti-inflammatory coating eliminates a major hindrance in the design of biocompatible meshes, and its potential application in developing medical implants with low immunogenicity is promising.

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Section: ■ Results and Discussionmentioning

confidence: 96%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synergistic Anti-inflammatory Coating “Zipped Up” on Polypropylene Hernia Mesh

Qiao

Zhang

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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A Review of Advanced Abdominal Wall Hernia Patch Materials

Liang,

Ding,

et al. 2023

Adv Healthcare Materials

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Tension‐free abdominal wall hernia patch materials (AWHPMs) play an important role in the repair of abdominal wall defects (AWDs), which have a recurrence rate of <1%. Nevertheless, there are still significant challenges in the development of tailored, biomimetic, and extracellular matrix (ECM)‐like AWHPMs that satisfy the clinical demands of abdominal wall repair (AWR) while effectively handling post‐operative complications associated with abdominal hernias, such as intra‐abdominal visceral adhesion and abnormal healing. This extensive review presents a comprehensive guide to the high‐end fabrication and the precise selection of these advanced AWHPMs. The review begins by briefly introducing the structures, sources, and properties of AWHPMs, and critically evaluates the advantages and disadvantages of different types of AWHPMs for AWR applications. The review subsequently summarizes and elaborates upon state‐of‐the‐art AWHPM fabrication methods and their key characteristics (e.g., mechanical, physicochemical, and biological properties in vitro/vivo). This review uses compelling examples to demonstrate that advanced AWHPMs with multiple functionalities (e.g., anti‐deformation, anti‐inflammation, anti‐adhesion, pro‐healing properties, etc.) can meet the fundamental clinical demands required to successfully repair AWDs. In particular, there have been several developments in the enhancement of biomimetic AWHPMs with multiple properties, and additional breakthroughs are expected in the near future.

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A Universal Nanogel‐Based Coating Approach for Medical Implant Materials

Ghosh

Keskin

Forson

et al. 2023

Advanced NanoBiomed Research

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Coatings are essential for biomedical applications antifouling and antimicrobial properties, supporting cell adhesion and tissue integration and particularly interesting in this field are nanogel (nGel)-based coatings. Since biomaterials differ in physiochemical properties, specific nGel-coating strategies need to be developed for every distinct material, leading to complex coating strategies. Hence, the solution lies in adopting a universal strategy to apply the same nGel coating with the same function on a wide range of implant surfaces. To this end, a universal nGel-based coating approach provides the same coating using a single method on implant materials including stiff polymer materials, metals, ceramics, glass, and elastomers. The coating formation is achieved by electrostatic interactions between oxygen plasma-activated surfaces and positively charged nGels using a spray-deposition method. Fluorescent labels are introduced into the nGels as a model for post-modification capabilities to increase the functionality of the coating. The coating is highly stable under in vitro physiological conditions with the retention of its function on different clinically relevant materials. Meanwhile, the in vivo study indicates that the nGel coating on a polyvinylidene fluoride hernia mesh is stable and biocompatible, therefore, making the coating and the coating strategy, a highly impactful approach for future clinical developments.

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Dopamine-Mediated Zwitterionic Polyelectrolyte-Coated Polypropylene Hernia Mesh with Synergistic Anti-inflammation Effects

Cited by 40 publications

References 56 publications

Synergistic Anti-inflammatory Coating “Zipped Up” on Polypropylene Hernia Mesh

Synergistic Anti-inflammatory Coating “Zipped Up” on Polypropylene Hernia Mesh

A Review of Advanced Abdominal Wall Hernia Patch Materials

A Universal Nanogel‐Based Coating Approach for Medical Implant Materials

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