Dopexamine and microcirculatory flow in transplanted small bowel: The Leeds experience

Bellamy, Mark; Mullane, D.; O'Beirne, H.; Young, Y.; Lodge, J.P.A.

doi:10.1016/s0041-1345(97)00093-6

Cited by 12 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We measured microvascular hemoglobin oxygen saturation (HbO 2 ) by reflectance spectrophotometry, a method validated in vitro and in vivo using oxygen electrodes (29,39), laser Doppler flowmetry (40), intravital microscopy (41), and hydrogen gas clearance (42). The lightguide was introduced into the stomach via an orogastric tube and placed facing the greater curvature, a site reported to represent the oxygenation of other gastric and upper intestinal regions (43).…”

Section: Critique Of Methodsmentioning

confidence: 99%

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Schwarte

Picker

Schindler

et al. 2004

Critical Care Medicine

View full text Add to dashboard Cite

During compromised cardiocirculatory conditions, alpha1-receptor activation during dopamine infusion prevented an increase in gastric mucosal oxygenation. Furthermore, selective DA1-stimulation (by fenoldopam) was insufficient to overcome the PEEP-induced depression of microHbO2. The responses of gastric mucosal oxygenation did not parallel changes in systemic oxygen transport. These findings were independent of fluid resuscitation.

show abstract

Section: Critique Of Methodsmentioning

confidence: 99%

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Schwarte

Picker

Schindler

et al. 2004

Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…It detects splanchnic ischemia with similar precision as laser Doppler flowmetry (25), intravital microscopy (26), and hydrogen gas clearance (27). In addition, the lightguide was nontraumatically introduced via a conventional orogastric tube and placed under endoscopic control facing the great curvature.…”

Section: Critique Of Methodsmentioning

confidence: 99%

Fenoldopam—but not dopamine—selectively increases gastric mucosal oxygenation in dogs

Schwarte

Picker²,

Schindler³

et al. 2003

Critical Care Medicine

View full text Add to dashboard Cite

Fenoldopam dose-dependently increased microvascular oxygenation of the gastric mucosa without changing systemic oxygen transport, i.e., this drug acted selectively on the splanchnic mucosa. The increase in gastric mucosal oxygenation was mediated by DA(1)-receptors. In contrast, dopamine markedly increased systemic oxygen transport, but did not affect microvascular oxygenation of gastric mucosa. This lacking effect on gastric mucosal oxygenation was not caused by alpha(1)-mediated vasoconstriction. The regional effects of both catecholamines could not be deduced from systemic hemodynamics and oxygenation.

show abstract

“…The mHbO 2 values reported are the means of the last 5 min (150 spectra, 2 s each) of the respective intervention under steady state conditions. This method allows detection of splanchnic ischemia with similar precision as laser flowmetry (Leung et al 1987), intra-vital microscopy (Bellamy et al 1997), or hydrogen gas clearance (Machens et al 1995). The non-traumatic instrumentation and in particular nontraumatic access to the gastric mucosa allows the determination of mucosal oxygenation in the absence of surgical stress.…”

Section: Measurementsmentioning

confidence: 99%

Vasopressin V1A receptors mediate the increase in gastric mucosal oxygenation during hypercapnia

Vollmer

Schwartges

Naber

et al. 2013

Journal of Endocrinology

View full text Add to dashboard Cite

Hypercapnia (HC) improves systemic oxygen delivery (DO 2 ) and microvascular hemoglobin oxygenation of the mucosa (mHbO 2 ). Simultaneously, HC increases plasma levels of vasopressin. Although vasopressin is generally regarded a potent vasoconstrictor particularly in the splanchnic region, its effects on splanchnic microcirculation during HC is unclear. The aim of this study was to evaluate the role of endogenous vasopressin on gastric mucosal oxygenation and hemodynamic variables during physiological (normocapnia) and hypercapnic conditions. Five dogs were repeatedly anesthetized to study the effect of vasopressin V 1A receptor blockade ([Pmp 1 ,Tyr(Me) 2 ]-Arg 8 -Vasopressin, 35 mg/kg) on hemodynamic variables and mHbO 2 during normocapnia or HC (end-tidal CO 2 70 mmHg). In a control group, animals were subjected to HC alone. mHbO 2 was measured by reflectance spectrophotometry, systemic DO 2 was calculated from intermittent blood gas analysis, and cardiac output was measured by transpulmonary thermodilution. Data are presented as meanGS.E.M. for nZ5 animals. During HC alone, DO 2 increased from 12G1 to 16G1 ml/kg per min and mHbO 2 from 70G4 to 80G2%. By contrast, additional vasopressin V 1A receptor blockade abolished the increase in mHbO 2 (80G2 vs 69G2%) without altering the increase in DO 2 (16G1 vs 19G 2 ml/kg per min). Vasopressin V 1A receptor blockade (VB) during normocapnia neither affected DO 2 (13G1 vs 14G1 ml/kg per min) nor mHbO 2 (75G3 vs 71G5%). Vasopressin V 1A receptor blockade abolished the increase in mHbO 2 during HC independent of DO 2 . Thus, in contrast to its generally vasoconstrictive properties, the vasopressin V 1A receptors seem to mediate the increase in gastric microcirculatory mucosal oxygenation induced by acute HC.

show abstract

Dopexamine and microcirculatory flow in transplanted small bowel: The Leeds experience

Cited by 12 publications

References 24 publications

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Fenoldopam—but not dopamine—selectively increases gastric mucosal oxygenation in dogs

Vasopressin V1A receptors mediate the increase in gastric mucosal oxygenation during hypercapnia

Contact Info

Product

Resources

About