Doppler and biochemical assessment for the prediction of early pregnancy outcome in patients experiencing threatened spontaneous abortion

Shehata, Nesreen A.A.; Ali, Hamada A.A.; Hassan, Abd El Gany M.A.; Katta, Maha; Ali, Ashraf S.F.

doi:10.1002/ijgo.12631

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…Sheehata et al [21] found no significant difference between the Doppler indices of the uterine artery. The patients' ages were significantly higher in the spontaneous abortion group than in the ongoing pregnancy group, which is consistent with previous studies reporting that inappropriate and inadequate progesterone secretion increases miscarriage rate due to ovarian aging [21,22]. In our study, age was significantly higher in the threatened miscarriage group and no significant differences were found in the indexes of spiral and uterine arteries by Doppler ultrasonography.…”

Section: Discussionmentioning

confidence: 92%

“…When spiral artery RI is normal, decreased uterine artery RI in the placental area may occur with a locally developing shunt [20]. Sheehata et al [21] found no significant difference between the Doppler indices of the uterine artery. The patients' ages were significantly higher in the spontaneous abortion group than in the ongoing pregnancy group, which is consistent with previous studies reporting that inappropriate and inadequate progesterone secretion increases miscarriage rate due to ovarian aging [21,22].…”

Section: Discussionmentioning

confidence: 99%

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The effect of uterine and spiral artery Doppler velocimetry in predicting miscarriage in threatened miscarriage patients

Okçu¹,

Gürbüz²

2021

Journal of Surgery and Medicine

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The effect of uterine and spiral artery Doppler velocimetry in predicting miscarriage in threatened miscarriage patients

Okçu¹,

Gürbüz²

2021

Journal of Surgery and Medicine

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“…Measurement of uterine artery blood flow can be performed in the second or third trimester to assess if the pregnancy is progressing normally; however, its value in the early first trimester is controversial. Some investigators have reported that an increased uterine artery pulsatility index (UTPI) or resistant index (RI) at between 6 and 12 weeks of pregnancy may precede the diagnosis of a miscarriage, 8,9 whereas other investigators have been unable to confirm this finding 10–12 . Earlier studies did not precisely time the assessment of uterine artery blood flow, ranging from 6–14 weeks of pregnancy, 8–10,12 which could have introduced bias and increased the variance of the results.…”

Section: Introductionmentioning

confidence: 99%

“…Some investigators have reported that an increased uterine artery pulsatility index (UTPI) or resistant index (RI) at between 6 and 12 weeks of pregnancy may precede the diagnosis of a miscarriage, 8,9 whereas other investigators have been unable to confirm this finding. [10][11][12] Earlier studies did not precisely time the assessment of uterine artery blood flow, ranging from 6-14 weeks of pregnancy, [8][9][10]12 which could have introduced bias and increased the variance of the results.…”

Section: Introductionmentioning

confidence: 99%

Comparison of uterine artery Doppler measurements at 6 weeks of pregnancy after IVF between pregnancies that resulted in miscarriage and ongoing pregnancies

Guo

Chaemsaithong

Huang

et al. 2020

Intl J Gynecology & Obste

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Objective To compare uterine artery pulsatility index (UTPI) at 6 weeks of pregnancy following in vitro fertilization (IVF) and embryo transfer (ET) between clinical pregnancies that resulted in a miscarriage and those that were ongoing beyond 12 weeks. Methods A prospective observational study was conducted in an IVF unit at Prince of Wales Hospital, Hong Kong, between December 1, 2017 and December 31, 2019. UTPI was measured at 6 weeks of pregnancy among women who conceived following IVF/ET. Results Among 153 participants, 22 (14.4%) had a miscarriage whereas 131 (85.6%) had an ongoing pregnancy beyond 12 weeks. Median UTPI in pregnancies that ended in a miscarriage was significantly lower than those that progressed beyond 12 weeks (2.1, IQR 1.9–2.4 vs 2.50, IQR 2.2–2.9, respectively; P<0.001). The likelihood of the pregnancy ending in a miscarriage when the UTPI was above the 75th percentile (>2.9), between the 25th–75th percentiles (2.2–2.9), and below the 25th percentile (<2.2) was 0%, 13.2%, and 27.7%, respectively (P=0.001). Conclusions IVF pregnancies that resulted in a miscarriage were associated with reduced resistance to uterine artery blood flow at 6 weeks of pregnancy.

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“…According to the World Health Organization [WHO], "abortion is defined as loss of a pregnancy before 20 weeks of gestation" [1] . Doppler ultrasound supply is used to measure blood velocity and flow [2] .…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Color Doppler Imaging in Normal and Abnormal First Trimester Pregnancy

Sileem

Mansour

Aabdelazem

2020

International Journal of Medical Arts

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Background: Color Doppler ultrasonography enables the non-invasive study of physiologic and pathophysiologic changes in the uterine and ovarian circulation in pregnant and non-pregnant women. Aim of the work:To evaluate the potential value of color Doppler of the uterine artery, corpus luteum blood flow, and subchorionic blood vessels in abnormal first-trimester pregnancy. Patients and methods: The study included 200 pregnant women in the first trimester in the antenatal care clinic of the Department of Obstetrics and Gynecology AL Azhar University [Assiut], divided into two groups; control group [100 cases] with normal pregnancy and study group [100 cases] which was further subdivided into threatened abortion [60 cases], blighted ovum [20 cases] and vesicular mole [20 cases]. Results:The uterine artery resistance index [RI] of the study groups was lower than the control group. The decrease was highly significant in the uterine artery RI of both threatened abortion and blighted ovum groups and significant in the vesicular mole group. Uterine artery pulsatility index [PI] showed a significant decrease in the study group compared with the control cases. There was a highly significant negative correlation between gestational age and both RI and PI of the study group's uterine artery. There was a higher prevalence of abortion in a group of threatened abortion compared to the control group. Conclusion:The prevalence of pregnancy complications is increased in association with abnormal blood flow patterns of the early uteroplacental circulation. Doppler indices of the early gestation uteroplacental circulation have an important value in the threatened abortion follow up.

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Doppler and biochemical assessment for the prediction of early pregnancy outcome in patients experiencing threatened spontaneous abortion

Abstract: Serum progesterone and CA125 are useful provisional predictors of spontaneous abortion, whereas the Doppler indices are not. The two biomarkers could be used as a basis to counsel anxious couples. CLINICALTRIALS.GOV: NCT02420769.

Cited by 12 publications

References 22 publications

The effect of uterine and spiral artery Doppler velocimetry in predicting miscarriage in threatened miscarriage patients

The effect of uterine and spiral artery Doppler velocimetry in predicting miscarriage in threatened miscarriage patients

Comparison of uterine artery Doppler measurements at 6 weeks of pregnancy after IVF between pregnancies that resulted in miscarriage and ongoing pregnancies

Comparative Study of Color Doppler Imaging in Normal and Abnormal First Trimester Pregnancy

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