Dorsal raphe nucleus stimulation modulates the response of layers IV and V barrel cortical neurons in rat

Sheibani, Vahid; Farazifard, Rasoul

doi:10.1016/j.brainresbull.2005.09.017

Cited by 12 publications

(13 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Before recording, all whiskers on the left side of the snout were trimmed to the length of 10 mm, and the trimmed D2 and D1 whiskers were inserted 1-2 mm into 2 small-diameter glass tubes that were attached to miniature speakers. The stimulus waveforms consisted of ramp-and-hold trapezoids, which produced 500 µm displacement (deflection of whiskers was about 500 µm in height) for a duration of 200 ms [13] . The amplitude of displacements was To assess the effect of DRN stimulation on barrel neuronal responses, 2 different protocols were used.…”

Section: Stimulationsmentioning

confidence: 99%

“…It was advanced 6.2 mm with an angle of 18 º relative to midline, to avoid bleeding from sagittal sinus [13,15] . The cortical surface was covered with 3% warm agar solution.…”

Section: Stimulationsmentioning

confidence: 99%

“…Our previous study has reported that the electrical stimulation of DRN modulates response properties of barrel cortex neurons to whisker stimulation [13] . However, little is known about how DRN activation changes the response properties of barrel cortex following long-term sensory deprivation, or which receptors are involved in this process.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of electrical stimulation of dorsal raphe nucleus on neuronal response properties of barrel cortex layer IV neurons following long-term sensory deprivation

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Stimulationsmentioning

confidence: 99%

“…It was advanced 6.2 mm with an angle of 18 º relative to midline, to avoid bleeding from sagittal sinus [13,15] . The cortical surface was covered with 3% warm agar solution.…”

Section: Stimulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of electrical stimulation of dorsal raphe nucleus on neuronal response properties of barrel cortex layer IV neurons following long-term sensory deprivation

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Therefore, the release of endogenous serotonin in the IC could be investigated by activating these nuclei electrically or chemically (for example, Sakai and Crochet 2001;Pobbe and Zangrossi 2005;Sheibani and Farazifard 2006). A disadvantage of this type of manipulation is that it would likely have relatively global effects, since these dorsal raphe neurons innervate extensive regions of the brain, including regions that are known to project to the IC (for example, cochlear nucleus: Zook and Casseday 1985,Oliver 1987,Vater and Feng 1990Klepper and Herbert 1991;amygdala: Marsh et al 2002,Jacobs et al 1978.…”

Section: Introductionmentioning

confidence: 99%

The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons

Hall

Hurley

2007

Hearing Research

View full text Add to dashboard Cite

Local direct application of the neuromodulator serotonin strongly influences auditory response properties of neurons in the inferior colliculus (IC), but endogenous stores of serotonin may be released in a distinct spatial or temporal pattern. To explore this issue, the serotonin releaser fenfluramine was iontophoretically applied to extracellularly recorded neurons in the IC of the Mexican free-tailed bat (Tadarida brasiliensis). Fenfluramine mimicked the effects of serotonin on spike count and first spike latency in most neurons, and its effects could be blocked by co-application of serotonin receptor antagonists, consistent with fenfluramine-evoked serotonin release. Responses to fenfluramine did not vary during single applications or across multiple applications, suggesting that fenfluramine did not deplete serotonin stores. A predicted gradient in the effects of fenfluramine with serotonin fiber density was not observed, but neurons with fenfluramine-evoked increases in latency occurred at relatively greater recording depths compared to other neurons with similar characteristic frequencies. These findings support the conclusion that there may be spatial differences in the effects of exogenous and endogenous sources of serotonin, but that other factors such as the identities and locations of serotonin receptors are also likely to play a role in determining the dynamics of serotonergic effects.

show abstract

“…As previously described (Motaghi et al, 2006;Sheibani and Farazifard, 2006), we used two tiny speakers to ensure controlled displacement of the whiskers. A thin glass tube with an internal diameter of 0.69 mm was attached to the center of each speaker.…”

Section: Whisker Stimulationmentioning

confidence: 99%

Neonatal capsaicin treatment modulates experience‐dependent plasticity in the rat barrel cortex

Sheibani

Shamsizadeh

Afarinesh

et al. 2010

J of Comparative Neurology

Self Cite

View full text Add to dashboard Cite

Previous studies have reported that capsaicin-induced C-fiber depletion results in expansion of low threshold somatosensory mechanoreceptive fields. Here we used this paradigm to investigate its effect on experience-dependent plasticity in the barrel cortex of rats. All but the D2 vibrissa were first plucked on postnatal day 0 (P0), P5, or P8, and kept plucked for a period of 30 days before being allowed to regrow for 7-9 days prior to the recording session. To assess receptive field characteristics the spared D2 principal whisker (PW) and the deprived D1 adjacent whisker (AW) were moved either singly or in concert, neuronal responses being recorded in layers IV and V of the D2 barrel. In vehicle-treated rats, PW-evoked ON responses (layer IV) were increased only in those animals that first had their vibrissae plucked on P0, whereas AW-evoked ON responses (layers IV and V) were decreased in the P0, P5, and P8 groups. In the capsaicin-treated animals, PW-evoked ON responses (layer IV) were increased in all three groups, but no decrease was recorded in the AW-evoked ON (layers IV and V) responses. In the vehicle- and capsaicin-treated animals, the greatest decrease in inhibitory interactions was observed in the P5 and P0 groups, respectively. These findings indicate that, following the induction of experience-dependent plasticity, the resultant changes in excitatory and integrative circuits can be further influenced by C-fiber depletion.

show abstract

Dorsal raphe nucleus stimulation modulates the response of layers IV and V barrel cortical neurons in rat

Cited by 12 publications

References 29 publications

Effects of electrical stimulation of dorsal raphe nucleus on neuronal response properties of barrel cortex layer IV neurons following long-term sensory deprivation

Effects of electrical stimulation of dorsal raphe nucleus on neuronal response properties of barrel cortex layer IV neurons following long-term sensory deprivation

The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons

Neonatal capsaicin treatment modulates experience‐dependent plasticity in the rat barrel cortex

Contact Info

Product

Resources

About