Dosage finding and outcome in the treatment of schizophrenic inpatients with amisulpride. Results of a drug utilization observation study

Scheel, Tabea; Eich, F.X.

doi:10.1002/hup.574

Cited by 30 publications

(17 citation statements)

References 33 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although in the present study no significant gender differences emerged with respect to either clinical response or tolerability, lower amisulpride doses for women with schizophrenia should be considered. The lack of differences in clinical effects could be due to the broad therapeutic window of amisulpride within a dose range between 50 mg and about 1600 mg [24]. However, higher prolactin levels under conventional antipsychotics [28] and amisulpride [9,11,37] have repeatedly been reported in females compared with males.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Gender Aspects in the Clinical Treatment of Schizophrenic Inpatients With Amisulpride: A Therapeutic Drug Monitoring Study

Müller¹,

Регенбоген²,

Sachse³

et al. 2006

Pharmacopsychiatry

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

“…For acute treatment of schizophrenic positive symptoms, doses of 400±800 mg are recommended [26,30]; in patients with severe positive symptoms, higher doses up to 1600 mg have been used successfully [24].…”

mentioning

confidence: 99%

Gender Aspects in the Clinical Treatment of Schizophrenic Inpatients With Amisulpride: A Therapeutic Drug Monitoring Study

Müller¹,

Регенбоген²,

Sachse³

et al. 2006

Pharmacopsychiatry

View full text Add to dashboard Cite

show abstract

“…The questionnaire is composed of 10 items which measure the EPS side effects from none (0) to severe (4).…”

Section: Friedman Test Of Extrapyramidal Symptoms (Eps)mentioning

confidence: 99%

“…Elderly females are more at risk of using polypharmacy 3 . As the courses of different diseases continue, the chance of using polypharmacy increases 3,4 . Polypharmacy is also defined as using two or more medications in treating diseases, which all share the same mechanism of action; however, using sertraline for depression, along with metformin for diabetics in the same patient, is not considered to be polypharmacy 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Antipsychotic Polypharmacy Versus Monotherapy in Elderly Patients with Chronic Schizophrenia: A Clinical Trial

Mirabzadeh

Shemshadi

Khodaei

et al. 2014

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

View full text Add to dashboard Cite

Objective: Antipsychotic polypharmacy in the elderly usually results in higher rates of interactions, side effects and increased cost. This research was designed to observe the benefits of replacing polypharmacy with a single medication in elderly patients with chronic schizophrenia. Methods: This was a quasi-experimental, prospective, descriptive and analytical clinical trial. A survey was performed at the long stay public and academic Tehran Razi Mental Hospital. From the initial 157 conveniently access patients, 59 cases were selected based on inclusion and exclusion criteria. Before intervention, 7 patients did not participate in the study due to the recent diagnosis of new medical conditions. Fifty-two (52) cases (males=13 and females= 39) entered and completed the 36 week research time period. At baseline 40 patients were receiving two types of antipsychotics, whereas, 11 patients were receiving three types and only 1 patient was receiving four types of antipsychotic drugs. In the pre-intervention period, the approval of the University`s ethics committee and the informed consents of the patients' relatives were obtained. Systematically, the patients` multiple antipsychotics were switched to a single medication, risperidone. After determining the equivalent dose of risperidone, it was started at 1 mg/day for all patients. After a 3-6 week cross-titration period, the patients reached the previously determined equivalent risperidone doses and completed 36 weeks until the end of the study. Clinical assessments including the Brief Psychotic Rating Scale (BPRS), Global Assessment of Functioning (GAF), and Extra-Pyramidal Syndrome (EPS) Scale were applied on a weekly basis for a 36 week period. Results: The mean BPRS scores of the participants showed statistically significant improvement after the 9 th week of intervention. Improvements were observed in all symptom dimensions of the BPRS (positive, negative and general schizophrenic symptoms). At the end of 36 weeks of risperidone use, 90.1% of the patients achieved at least a 50% reduction in their symptoms. Additionally, functional improvement and a lower incidence of extrapyramidal side effects were also achieved after 36 weeks of risperidone use in the study population. Conclusion: Risperidone may be considered safe as a monotherapy alternative for elderly patients with chronic schizophrenia who are being treated with multiple concomitant antipsychotics. This replacement may result in some clinical benefits and fewer side effects.

show abstract

“…Psychotropic medications are widely prescribed 23,24 and the utilization of psychotropic drugs is a topic of increasing interest.…”

Section: Pie Diagram Shows the Psychiatric Disorder For Which Psychotmentioning

confidence: 99%

Patterns of Prescription in a Psychiatry Out Patient Department in a Teaching Hospital in Bangladesh

Any

Parveen

Ara³

et al. 2014

Bangladesh J Physiol Pharmacol

View full text Add to dashboard Cite

A cross-sectional descriptive study was carried out among individuals attending the psychiatry outpatient department from February 1 st 2010 to April 30 th 2010 in Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh to see the patterns of prescription and drug use in psychiatry out-patient department of teaching hospital in Bangladesh.A total of 300 patient were included in this study. The average number of drugs per encounter was 2.44 drugs were prescribed by generic name. The commonest clinical indication were schizophrenia and other psychotic disorder (40%) and use of psychotropic drug (36%) frequently but injection use(8.33%) was very low, additional (anticholinergic) drugs were prescribed 76% of prescription. Average cost of drugs per prescription was 181 taka. So, the study will help to understand the trends in prescribing psychotropic drugs and will provide guidelines for designing appropriate future intervention strategies in order to promote rational prescribing and improve the quality of health care.

show abstract

Dosage finding and outcome in the treatment of schizophrenic inpatients with amisulpride. Results of a drug utilization observation study

Cited by 30 publications

References 33 publications

Gender Aspects in the Clinical Treatment of Schizophrenic Inpatients With Amisulpride: A Therapeutic Drug Monitoring Study

Gender Aspects in the Clinical Treatment of Schizophrenic Inpatients With Amisulpride: A Therapeutic Drug Monitoring Study

Antipsychotic Polypharmacy Versus Monotherapy in Elderly Patients with Chronic Schizophrenia: A Clinical Trial

Patterns of Prescription in a Psychiatry Out Patient Department in a Teaching Hospital in Bangladesh

Contact Info

Product

Resources

About