Dose and duration-dependent toxicological evaluation of lead acetate in chicks

Hussain, Saeeda; Ali, Shaukat; Mumtaz, Sadaf; Shakir, Hafiz Abdullah; Ahmad, Farooq; Tahir, Hafız Muhammad; Ulhaq, Mazhar; Khan, Muhammad Azmat Ullah; Zahid, Muhammad

doi:10.1007/s11356-020-08016-8

Cited by 28 publications

(16 citation statements)

References 42 publications

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“…The current study was undertaken to evaluate the toxicological effects of lead acetate on biochemical parameters as well as its bioaccumulation in the liver, kidney and brain of broiler birds. The in uence of lead acetate disclosure was equally time and concentration dependent (Hussain et al 2020). Lead is one of the noxious heavy metals that cause toxicity in human beings and birds (Jiao et al 2017).…”

Section: Discussionmentioning

confidence: 99%

“…All animal trials were executed according to local and worldwide procedures. The nearby way is the Wet op de dierproeven (article 9) of Dutch law (international) and an associated rule planned via the Bureau of Animal Research Licensing, Local University as detailed in our earlier papers (Saba et al 2021;Hussain et al 2020;Ara et al 2021;Khan et al 2019;Ali et al 2019;Mumtaz et al 2019;Mughal et al 2019;Dar et al 2019). The rearing and use of animal were carried out using NIH Publication "Guide for the Care and Use of Laboratory Animals" (NRC 2004)…”

Section: Ethical Statementmentioning

confidence: 99%

“…Two weeks old thirty chicks (Gallus domesticus) Ross 308 was purchased from the local market (Hussain et al 2020). The birds were kept in oor pens and fed on a commercially available corn-based starter diet and drinking water at their satiation.…”

Section: Experimental Design and Management Of Chicksmentioning

confidence: 99%

“…Serum was isolated from plasma via centrifuged at 2000 rpm for 10 minutes to analyze the biochemical parameters. For biochemical analyses, serum samples were kept at -20°C (Hussain et al 2020;Naito, 1984). Various biochemical parameters were analyzed by commercially available respective kits or already designated methods (Suleman et al 2016;Mumtaz et al 2019;Ali et al 2019;Khan et al 2019;Hussain et al 2020)…”

Section: Biochemical Analyses (Blood Biochemistry)mentioning

confidence: 99%

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Large scale toxicological evaluation of lead acetate in broiler chicken

Ali¹,

Minhas²,

Awan³

et al. 2021

Preprint

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Among heavy metals, lead is one of the very toxic pollutants of the environment. Its accumulating nature in the body makes it a great threat to public health particularly when humans consume lead intoxicated foods like chickens. The main purpose of the conducted research was to elucidate the bioaccumulation of lead in different organs of chickens and its toxicological effects on various organs and biochemical parameters. An experimental study on the effect of lead acetate toxicity in chicks was conducted by orally administration for consecutive thirty days. Thirty-chicks were categorized into A, B, C, D, E, and F groups with lead acetate dose rate 0, 71, 142, 213, and 284 mg/kg body weight, correspondingly. During the experiment, various biochemical parameters (uric acid, GPT, creatinine, ALP, LDH, ASAT, ALT, glutathione, superoxide dismutase) were measured employing commercially available kits. At the end of experimentation, and lead accumulation in liver, kidney and brain was estimated by absorption spectrophotometer. Some biochemical parameters like uric acid, GPT, creatinine, ALP, LDH, AST, and ALT were increased while the level of glutathione and superoxide dismutase, was found to be decreased after exposure to lead acetate. In present study, the pattern of metal accumulation in different organs directly related with concentration of metal. The order of metal accumulation in organs is; liver > kidney > brain. In the present study, supplementation of lead acetate has affected the exposed chicken. Mostly the blood profile and chemistry are perturbed. These effects might be due to the accumulation of lead in the brain, kidneys, and liver which may result in neurotoxicity, nephrotoxicity, and hepatotoxicity. To refine such outcomes, further studies in the future are recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Ethical Statementmentioning

confidence: 99%

Section: Experimental Design and Management Of Chicksmentioning

confidence: 99%

Section: Biochemical Analyses (Blood Biochemistry)mentioning

confidence: 99%

See 2 more Smart Citations

Large scale toxicological evaluation of lead acetate in broiler chicken

Ali¹,

Minhas²,

Awan³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…All animal trial techniques were directed as per local and worldwide controls. The nearby direction is the Wet op de dierproeven (Article 9) of Dutch Law (International) as detailed in our previous studies (Ali et al, 2020a;Ali et al, 2020b;Hussain et al, 2020;Ara et al, 2020;Ali et al, 2019;Khan et al, 2019;Mumtaz et al, 2019;Mughal et al, 2019;Dar et al, 2019) and The Institutional Bioethics Committee at Government College University Lahore, Pakistan (No. GCU/IIB/21 dated: 08-01-2019).…”

Section: Ethical Statementmentioning

confidence: 99%

Silk derived formulations for accelerated wound healing in diabetic mice

Tariq¹,

Tahir²,

Butt³

et al. 2021

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Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

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Lead exposure does not affect baseline and induced innate immunity in quails

Melhado

Menegário

et al. 2022

J Exp Zool Pt A

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Lead (Pb) is one of the most common metals found in ecosystems in elevated concentrations derived mainly from anthropogenic activities. Pb toxicity is of special concern in birds due to its capacity for bioaccumulation in the liver, bones, and kidneys causing physiological disruptions. Such disruptions can be lethal in a few days after Pb acute intoxication and they are associated with several million deaths of birds. Moreover, Pb may work as an immunosuppressant as it affects the cell‐mediated and humoral immune responses, including components of the acute‐phase response (APR). We (1) examined the effects of Pb contamination on the innate immune system, body mass, and food intake of Japanese quails (Coturnix coturnix japonica), and (2) evaluated the effects of Pb on its APR after exposing the animals to Pb acetate in drinkable water during 7 days. We found that Pb contamination increased the number of circulating white blood cells (WBCs), but no effect was found on body mass, food intake, the heterophil/lymphocyte (H/L) ratio, and haptoglobin (Hp) concentration. When Pb‐exposed birds were injected with lipopolysaccharide from Escherichia coli to activate the APR, they had a negative body mass ratio, reduced food intake, and increased the number of WBCs, the H/L ratio, and the Hp concentration. We conclude that Pb exposure at this dose did not affect baseline values of the constitutive response and that it did not affect the APR of quails, but commend for further studies testing the effect of different Pb doses.

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Dose and duration-dependent toxicological evaluation of lead acetate in chicks

Cited by 28 publications

References 42 publications

Large scale toxicological evaluation of lead acetate in broiler chicken

Large scale toxicological evaluation of lead acetate in broiler chicken

Silk derived formulations for accelerated wound healing in diabetic mice

Lead exposure does not affect baseline and induced innate immunity in quails

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