Dose- and time- effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution

Ding, Rui; Jin, Yaqing; Liu, Xinneng; Ye, Huaizhuang; Zhu, Ziyi; Zhang, Yuan; Wang, Ting; Xu, Yuzi

doi:10.1038/srep43737

Cited by 42 publications

(27 citation statements)

References 54 publications

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“…Meanwhile, results from multiple analyses, including DNA methylation frequency changes (Table ), hierarchical AMOVA (Table ) and shared DNA methylation state of the 2‐408 locus after multiple challenges, clearly showed time‐dependent effects of DNA methylation changes. Time–effect response of DNA methylation was also found in rats exposed to traffic‐related air pollution (Ding et al., ). All these results demonstrate that DNA methylation can rapidly respond to abiotic stresses and timely DNA methylation‐mediated adjustment of functional genes expression can be essential for survival in harsh environments.…”

Section: Discussionmentioning

confidence: 87%

Rapid response to changing environments during biological invasions: DNA methylation perspectives

Huang

et al. 2017

Molecular Ecology

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Dissecting complex interactions between species and their environments has long been a research hot spot in the fields of ecology and evolutionary biology. The well-recognized Darwinian evolution has well-explained long-term adaptation scenarios; however, "rapid" processes of biological responses to environmental changes remain largely unexplored, particularly molecular mechanisms such as DNA methylation that have recently been proposed to play crucial roles in rapid environmental adaptation. Invasive species, which have capacities to successfully survive rapidly changing environments during biological invasions, provide great opportunities to study molecular mechanisms of rapid environmental adaptation. Here, we used the methylation-sensitive amplified polymorphism (MSAP) technique in an invasive model ascidian, Ciona savignyi, to investigate how species interact with rapidly changing environments at the whole-genome level. We detected quite rapid DNA methylation response: significant changes of DNA methylation frequency and epigenetic differentiation between treatment and control groups occurred only after 1 hr of high-temperature exposure or after 3 hr of low-salinity challenge. In addition, we detected time-dependent hemimethylation changes and increased intragroup epigenetic divergence induced by environmental stresses. Interestingly, we found evidence of DNA methylation resilience, as most stress-induced DNA methylation variation maintained shortly (~48 hr) and quickly returned back to the control levels. Our findings clearly showed that invasive species could rapidly respond to acute environmental changes through DNA methylation modifications, and rapid environmental changes left significant epigenetic signatures at the whole-genome level. All these results provide fundamental background to deeply investigate the contribution of DNA methylation mechanisms to rapid contemporary environmental adaptation.

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Section: Discussionmentioning

confidence: 87%

Rapid response to changing environments during biological invasions: DNA methylation perspectives

Huang

et al. 2017

Molecular Ecology

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“…Several studies revealed that the changes of H3K9ac and H3K27ac were associated with air pollution that induced respiratory disorders. 29,30 A previous study conducted by Cui et al . indicated that the acetylation levels of H3K9ac, H3K14ac, H3K27ac, and H3K18ac were obviously elevated in asthmatic lung tissues compared to the control group, 31 which corroborated with our finding.…”

Section: Discussionmentioning

confidence: 98%

Identification of histone acetylation in a murine model of allergic asthma by proteomic analysis

Ren

Bai

et al. 2020

Exp Biol Med (Maywood)

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The pathogenesis of asthma is closely related to histone acetylation modification, but the specific acetylation sites related to this process remain indistinct. Herein, our study sought to identify differentially modified acetylation sites and their expression distribution in cells involved in asthma in lung tissues. The airway hyper-responsiveness, inflammation, and remodeling were assessed by non-invasive whole-body plethysmography, ELISA, and hematoxylin-eosin staining to confirm the successful establishment of the allergic asthma model. Afterward, the differentially modified acetylation sites in asthmatic lung tissues were identified and validated by using proteomics and western blotting, respectively. The immunohistochemistry analysis was applied to reveal the distribution of identified acetylation sites in asthmatic lung tissues. A total of 15 differentially modified acetylation sites, including 13 upregulated (H3K9ac, H3K14ac, H3K18ac, H3K23ac,H3K27ac, H3K36ac, H2B1KK120ac, H2B2BK20ac, H2BK16ac, H2BK20ac, H2BK108ac, H2BK116ac, and H2BK120ac) and 2 downregulated (H2BK5ac and H2BK11ac) sites were identified and validated. Furthermore, immunohistochemical staining of lung tissues showed that nine of the identified histone acetylation sites (H2BK5, H2BK11, H3K18, H2BK116, H2BK20, H2BK120, H3K9, H3K36, and H3K27) were differentially expressed in airway epithelial cells, and the acetylation of identified H3 histones were observed in both eosinophil and perivascular inflammatory cells. Additionally, differential expression of histone acetylation sites was also observed in nucleus of airway epithelial cells, vascular smooth muscle cells, perivascular inflammatory cells, and airway smooth muscle cells. In conclusion, we identified potential acetylation sites associated with asthma pathogenesis. These findings may contribute greatly in the search for therapeutic approaches for allergic asthma.

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“…Given that the histone acetylation is a dynamic and cell-specific process 23 , CD4 + T lymphocytes rather than PBMCs mixture were isolated from peripheral blood in the present study. As a wide range of autoimmune disease 10,24 or subtle stimuli 25 have been found to be associated with epigenetic changes, we enrolled patients with new-onset diabetes without complications and with insulin as the only medication. Covariates including age, sex and body mass index were well matched with controls, allowing for a more accurate determination of the acetylation pattern specific to type 1 diabetes rather than physiological causes.…”

Section: Discussionmentioning

confidence: 99%

Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes

Wang

Hou

Wisler

et al. 2018

J of Diabetes Invest

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Dose- and time- effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution

Cited by 42 publications

References 54 publications

Rapid response to changing environments during biological invasions: DNA methylation perspectives

Rapid response to changing environments during biological invasions: DNA methylation perspectives

Identification of histone acetylation in a murine model of allergic asthma by proteomic analysis

Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes

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