Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non–small-cell lung cancer

Murshed, Hasan; Liu, H.Helen; Liao, Zhongxing; Barker, Jerry L.; Wang, Xiaochun; Tucker, Susan L.; Chandra, Anurag; Guerrero, Thomas; Stevens, Craig W.; Change, Joe Y; Jeter, M.; Cox, James D.; Komaki, Ritsuko; Mohan, Radhe

doi:10.1016/j.ijrobp.2003.09.086

Cited by 248 publications

(159 citation statements)

References 27 publications

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“…Results showed that with IMRT there was a 10% reduction in the predicted rate of radiation pneumonitis and an overall decrease in the MLD of >2 Gy. 12 Christian et al, in a study of 10 patients with NSCLC, retrospectively compared 5 different IMRT plans using different fields (3,5,7, and 9 coplanar field and a 6 noncoplanar field ) to a six-field noncoplanar 3D-CRT plan for each patient. They found that using IMRT reduced the V 20 when more than 3 fields were used as compared to the 3D-CRT plan.…”

Section: Introductionmentioning

confidence: 99%

Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: The Memorial Sloan-Kettering Cancer Center (MSKCC) experience

Sura

Gupta

Yorke

et al. 2008

Radiotherapy and Oncology

126

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Section: Introductionmentioning

confidence: 99%

Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: The Memorial Sloan-Kettering Cancer Center (MSKCC) experience

Sura

Gupta

Yorke

et al. 2008

Radiotherapy and Oncology

126

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“…This risk of radiation pneumonitis can be reduced by up to 10% using intensity-modulated radiotherapy (IMRT), without compromise in tumour dose delivery [7,8].…”

mentioning

confidence: 99%

Functional image-based radiotherapy planning for non-small cell lung cancer: A simulation study

Bates

Bragg

Wild

et al. 2009

Radiotherapy and Oncology

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“…In a planning study by Murshed, it was suggested that if MLD was decreased by 2 Gy the risk of RP could be reduced by 10% 32. It was reported that introducing V5 constraint could significantly decreased the lethal pneumonitis.…”

Section: Discussionmentioning

confidence: 99%

Reducing dose to the lungs through loosing target dose homogeneity requirement for radiotherapy of non small cell lung cancer

Miao

Yan

Tian

et al. 2017

J Applied Clin Med Phys

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It is important to minimize lung dose during intensity‐modulated radiation therapy (IMRT) of nonsmall cell lung cancer (NSCLC). In this study, an approach was proposed to reduce lung dose by relaxing the constraint of target dose homogeneity during treatment planning of IMRT. Ten NSCLC patients with lung tumor on the right side were selected. The total dose for planning target volume (PTV) was 60 Gy (2 Gy/fraction). For each patient, two IMRT plans with six beams were created in Pinnacle treatment planning system. The dose homogeneity of target was controlled by constraints on the maximum and uniform doses of target volume. One IMRT plan was made with homogeneous target dose (the resulting target dose was within 95%–107% of the prescribed dose), while another IMRT plan was made with inhomogeneous target dose (the resulting target dose was more than 95% of the prescribed dose). During plan optimization, the dose of cord and heart in two types of IMRT plans were kept nearly the same. The doses of lungs, PTV and organs at risk (OARs) between two types of IMRT plans were compared and analyzed quantitatively. For all patients, the lung dose was decreased in the IMRT plans with inhomogeneous target dose. On average, the mean dose, V5, V20, and V30 of lung were reduced by 1.4 Gy, 4.8%, 3.7%, and 1.7%, respectively, and the dose to normal tissue was also reduced. These reductions in DVH values were all statistically significant (P < 0.05). There were no significant differences between the two IMRT plans on V25, V30, V40, V50 and mean dose for heart. The maximum doses of cords in two type IMRT plans were nearly the same. IMRT plans with inhomogeneous target dose could protect lungs better and may be considered as a choice for treating NSCLC.

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Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non–small-cell lung cancer

Cited by 248 publications

References 27 publications

Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: The Memorial Sloan-Kettering Cancer Center (MSKCC) experience

Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: The Memorial Sloan-Kettering Cancer Center (MSKCC) experience

Functional image-based radiotherapy planning for non-small cell lung cancer: A simulation study

Reducing dose to the lungs through loosing target dose homogeneity requirement for radiotherapy of non small cell lung cancer

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