Dose-Dependent Effects in Plasma Oncotherapy: Critical In Vivo Immune Responses Missed by In Vitro Studies

He, Yanlin; Gong, Fanwu; Jin, Tao; Liu, Qi; Fang, Haopeng; Chen, Yan; Wang, Guomin; Chu, Paul K.; Wu, Zhengwei; Ostrikov, Kostya

doi:10.3390/biom13040707

Cited by 7 publications

(3 citation statements)

References 64 publications

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“…Furthermore, a proper adjustment of these elements may be crucial when defining a suitable dose of different treatments. It has been reported by many researchers that dose-dependent therapy with increased exposure duration results in promising improvements and achievements when it comes to the treatment effects on several cancer cell lines [73]. Multiple studies show that atmospheric plasma, when directed at the damaged tissue location, decreases progress in the spread of metastases [74,75].…”

Section: Cancer Treatmentmentioning

confidence: 99%

The Promising Potential of Cold Atmospheric Plasma Therapies

Stańczyk,

Wiśniewski

2024

Plasma

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The outstanding properties and chemistry of cold atmospheric plasma (CAP) are not sufficiently understood due to their relatively complex systems and transient properties. In this paper, we tried to present a detailed review of the applications of CAP in modern medicine, highlighting the biochemistry of this phenomenon. Due to its unique characteristics, CAP has emerged as a promising tool in various medical applications. CAP, as a partially—or fully ionized—gas-retaining state of quasi-neutrality, contains many particles, such as electrons, charged atoms, and molecules displaying collective behaviour caused by Coulomb interactions. CAP can be generated at atmospheric pressure, making it suitable for medical settings. Cold plasma’s anti-microbial properties create an alternative method to antibiotics when treating infections. It also enhances cell proliferation, migration, and differentiation, leading to accelerated tissue regeneration. CAP can also be a powerful tool in anti-tumour therapies, stem cell proliferation, dental applications, and disease treatment, e.g., neurology. It is our belief that this article contributes to the deeper understanding of cold plasma therapy and its potential in medicine. The objective of this study is to demonstrate the potential of this relatively novel approach as a promising treatment modality. By covering a range of various biomedical fields, we hope to provide a comprehensive overview of CAP applications for multiple medical conditions. In order to gain further insight into the subject, we attempted to gather crucial research and evidence from various studies, hopefully creating a compelling argument in favour of CAP therapy. Our aim is to highlight the innovative aspects of CAP therapy where traditional methods may have limitations. Through this article, we intend to provide a convenient reference source for readers engaged in the examination of CAP’s potential in medicine.

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Section: Cancer Treatmentmentioning

confidence: 99%

The Promising Potential of Cold Atmospheric Plasma Therapies

Stańczyk,

Wiśniewski

2024

Plasma

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“…It can influence cell signaling pathways, leading to alterations in gene expression and cell behavior [26,27]. This capability led to therapeutic applications, such as in wound healing and cancer treatment [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Decontamination of Water-Containing Objects Using Piezoelectric Direct Discharge Plasma and Plasma Jet

Konchekov,

Gudkova,

Burmistrov

et al. 2024

Biomolecules

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Cold atmospheric plasma has become a widespread tool in bacterial decontamination, harnessing reactive oxygen and nitrogen species to neutralize bacteria on surfaces and in the air. This technology is often employed in healthcare, food processing, water treatment, etc. One of the most energy-efficient and universal methods for creating cold atmospheric plasma is the initiation of a piezoelectric direct discharge. The article presents a study of the bactericidal effect of piezoelectric direct discharge plasma generated using the multifunctional source “CAPKO”. This device allows for the modification of the method of plasma generation “on the fly” by replacing a unit (cap) on the working device. The results of the generation of reactive oxygen and nitrogen species in a buffer solution in the modes of direct discharge in air and a plasma jet with an argon flow are presented. The bactericidal effect of these types of plasma against the bacteria E. coli BL21 (DE3) was studied. The issues of scaling the treatment technique are considered.

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“…It was mainly applied to such areas as wound healing [14], oral treatment [15], microbial inactivation, and cancer treatment [16,17]. At present, low-temperature plasma medicine is widely used in dozens of cancers, such as skin cancer [18], melanoma [19], and colon cancer [20]. There are two main ways for LTP to treat cells.…”

Section: Introductionmentioning

confidence: 99%

Low-Temperature Plasma-Activated Medium Inhibits the Migration of Non-Small Cell Lung Cancer Cells via the Wnt/β-Catenin Pathway

Zhang

Yan

et al. 2023

Biomolecules

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This study explored the molecular mechanism of the plasma activation medium (PAM) inhibiting the migration ability of NSCLC (non-small cell lung cancer) cells. The effect of PAM incubation on the cell viability of NSCLC was detected through a cell viability experiment. Transwell cells and microfluidic chips were used to investigate the effects of PAM on the migration capacity of NSCLC cells, and the latter was used for the first time to observe the changes in the migration capacity of cancer cells treated with PAM. Moreover, the molecular mechanisms of PAM affecting the migration ability of NSCLC cells were investigated through intracellular and extracellular ROS detection, mitochondrial membrane potential, and Western blot experiments. The results showed that after long-term treatment with PAM, the high level of ROS produced by PAM reduced the level of the mitochondrial membrane potential of cells and blocked the cell division cycle in the G2/M phase. At the same time, the EMT process was reversed by inhibiting the Wnt/β-catenin signaling pathway. These results suggested that the high ROS levels generated by the PAM treatment reversed the EMT process by inhibiting the WNT/β-catenin pathway in NSCLC cells and thus inhibited the migration of NSCLC cells. Therefore, these results provide good theoretical support for the clinical treatment of NSCLC with PAM.

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Dose-Dependent Effects in Plasma Oncotherapy: Critical In Vivo Immune Responses Missed by In Vitro Studies

Cited by 7 publications

References 64 publications

The Promising Potential of Cold Atmospheric Plasma Therapies

The Promising Potential of Cold Atmospheric Plasma Therapies

Bacterial Decontamination of Water-Containing Objects Using Piezoelectric Direct Discharge Plasma and Plasma Jet

Low-Temperature Plasma-Activated Medium Inhibits the Migration of Non-Small Cell Lung Cancer Cells via the Wnt/β-Catenin Pathway

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