Dose-dependent induction of IL-6 by plant-derived proteases<i>in vitro</i>

Rose, B.; Herder, Christian; Löffler, Heike; Meierhoff, Guido; Schloot, Nanette C.; Walz, Michael; Martin, Stéphan

doi:10.1111/j.1365-2249.2005.02970.x

Cited by 22 publications

(17 citation statements)

References 38 publications

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“…In contrast to the current study, several in vitro studies have shown that bromelain treatment can actually increase production of pro-inflammatory cytokines such as IL-6, TNF, IFN-γ, GM-CSF by macrophages, NK cells, and mixed lymphocyte cultures (42)(43)(44). Additional studies are needed to address the mechanisms by which bromelain affects colon tissues.…”

Section: Discussioncontrasting

confidence: 92%

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro

Onken

Greer

Calingaert

et al. 2008

Clinical Immunology

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Oral bromelain has been anecdotally reported to decrease inflammation in ulcerative colitis (UC). Proteolytically active bromelain is known to decrease expression of mRNAs encoding proinflammatory cytokines by human leukocytes in vitro. To assess the effect of bromelain on mucosal secretion of cytokines in inflammatory bowel disease (IBD), endoscopic colon biopsies from patients with UC, Crohn's disease (CD), and non-IBD controls were treated in vitro with bromelain or media, then cultured. Secretion of pro-inflammatory cytokines and chemokines was measured. Significant increases in granulocyte colony stimulating factor (G-CSF), interferon (IFN)-γ, interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) were detected in the media from actively inflamed areas in UC and CD as compared with non-inflamed IBD tissue and non-IBD controls. In vitro bromelain treatment decreased secretion of G-CSF, granulocyte-macrophage colony stimulating factor (GM-CSF), IFN-γ, CCL4/macrophage inhibitory protein (MIP)-1β, and TNF by inflamed tissue in IBD. Bromelain may be a novel therapy for IBD.

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Section: Discussioncontrasting

confidence: 92%

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro

Onken

Greer

Calingaert

et al. 2008

Clinical Immunology

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“…In addition to secondary metabolites, the proteolytic enzymes present in papaya (papain and chymopapain) have also shown immunomodulatory and anti-inflammatory activities (Rakhimov 2001;Rose et al 2006;Mohr & Desser 2013). The role of transforming growth factor (TGF)-b in anti-inflammation is evident.…”

Section: Anti-inflammatory Activities Of Papaya-associated Phytochemimentioning

confidence: 99%

Anti-inflammatory and immunomodulatory properties of Carica papaya

Pandey

Cabot

Shaw

et al. 2016

Journal of Immunotoxicology

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Chronic inflammation is linked with the generation and progression of various diseases such as cancer, diabetes and atherosclerosis, and anti-inflammatory drugs therefore have the potential to assist in the treatment of these conditions. Carica papaya is a tropical plant that is traditionally used in the treatment of various ailments including inflammatory conditions. A literature search was conducted by using the keywords ''papaya'', ''anti-inflammatory and inflammation'' and ''immunomodulation and immune'' along with cross-referencing. Both in vitro and in vivo investigation studies were included. This is a review of all studies published since 2000 on the antiinflammatory activity of papaya extracts and their effects on various immune-inflammatory mediators. Studies on the anti-inflammatory activities of recognized phytochemicals present in papaya are also included. Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking. ARTICLE HISTORY

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“…Rose et al . () also report a dose‐dependent induction of IL‐6 production, while there was no effect on the production of IFNγ and IL‐10. On the other hand the investigations by Huang et al .…”

Section: Introductionmentioning

confidence: 89%

Placebo‐controlled Randomized Clinical Trial on the Immunomodulating Activities of Low‐ and High‐Dose Bromelain after Oral Administration – New Evidence on the Antiinflammatory Mode of Action of Bromelain

Müller

März

Schmolz³

et al. 2012

Phytotherapy Research

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Bromelain is used for treatment of inflammatory diseases since decades. However, the exact mechanism of action remains poorly understood. While in vitro investigations have shown conflicting effects on the release of various cytokines, no in vivo data were available.In this study, the effects on inflammation-related cytokines of two doses of bromelain were tested in a single dose placebo-controlled 3 x crossover randomised clinical trial. Cytokine circadian profiles were used to investigate the effects of bromelain on the human immune system by using stimulated whole-blood leukocytes.The effects seen in these cultures demonstrated a significant shift in the circadian profiles of the Th1 cell mediator IFNγ (p<0.043) after bromelain 3000 F.I.P., and trends in those of the Th2-type cytokine IL-5 as well as the immunosuppressive cytokine IL-10. This suggests a general effect on the antigen-specific (T cell) compartment of the human immune system. Conclusion:This is the first time that bromelain was shown to modulate the cellular responses of lymphocyte after oral use. It is postulated that the immunomodulating effect of bromelain observed in this trial is part of its known anti-inflammatory activities. Further investigations will be necessary to verify the relevance of these findings to a diseased immune system.

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Dose-dependent induction of IL-6 by plant-derived proteasesin vitro

Cited by 22 publications

References 38 publications

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro

Anti-inflammatory and immunomodulatory properties of Carica papaya

Placebo‐controlled Randomized Clinical Trial on the Immunomodulating Activities of Low‐ and High‐Dose Bromelain after Oral Administration – New Evidence on the Antiinflammatory Mode of Action of Bromelain

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