Dose Escalation Phase I Study in Healthy Volunteers to Evaluate the Safety of a Natural Product PM701

Khorshid, Faten; Alshazly, H.; Jefery, A. Al; Osman, Amira

doi:10.3923/jpt.2010.91.97

Cited by 10 publications

(8 citation statements)

References 10 publications

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“…The results of the current study of the cytotoxic effects of purified fractions of PMF on different types of cancer cell lines are in accord with those of previous studies [43][44][45][46][47] reporting the cytotoxic effect of PM701 (lyophilized camel urine) on cancer cell lines such as A549, L1210, HCT116, HepG2, MCF-7 and U251. Moreover, other fractions of camel urine such as PM701 and its bioactive fraction PMF and sub-fraction PMFK were shown to have cytotoxic properties against different cancer cell lines.…”

Section: Discussionsupporting

confidence: 80%

“…As with the current study, a previous study [41][42][43][44][45][46] demonstrated that PM701, its bioactive fraction (PMF), and its sub-fraction (PMFK) all exhibit anti-cancer activity. Another study examined the effect of lyophilized PM701 and its bioactive fractions on the growth of breast cancer cells (MCF-7).…”

Section: Discussionmentioning

confidence: 70%

“…This natural product, which has been used for many years for the treatment of a range of human diseases and without any reported harmful effects, is of considerable interest on the basis of its anticancer activity. In fact, early Phase I clinical trials using capsules and syrup containing PMF have been carried out on healthy volunteers to confirm that no harmful side effects were caused [43]. Further work on PMF is required and this agent remains under intensive investigation.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Cytotoxic Effect of Small and Large Molecules of PMF Fraction Extracted from Camel Urine on Cancer Cells

Mahboub

Khorshid

Emwas

2015

BJMMR

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Aim of the work: Animal urine, including that of camels, has long been used for the therapeutic management of human ailments. In this study, we sought to characterize the cytotoxic properties of newly derived purified fractions from previously described camel urine extract (PMF) on various cancer cell lines. Methodology: Two new size dissimilar fractions of PMF (large and small) were obtained by fractionalizing PMF using 3kD and 50kD membrane filters. A SRB cytotoxicity assay of the PMF Mahboub et al.; BJMMR, 6(4): 384-396, 2015; Article no.BJMMR.2015.213 385 fractions was performed on cancer cell lines (A549, HCT116, HepG2, MCF-7, U251 and Hela) as well as normal cell lines (human fibroblast cell line and Vero). Results: This study showed that the newly derived and more purified fraction of PMF (new PMF) possesses effective and selective anti-cancer properties against several types of cancer cell lines. Conclusion: This study, as well as previous ones, suggests that camel urine extracts (old and new PMF) may provide newer therapeutic alternatives to clinically manage cancer patients. However, further studies are needed to verify these positive preliminary results. Original Research Article

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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The Cytotoxic Effect of Small and Large Molecules of PMF Fraction Extracted from Camel Urine on Cancer Cells

Mahboub

Khorshid

Emwas

2015

BJMMR

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“…As a result, it has found to be safe to human use as no change in the architectures and hepatotoxic, nephrotoxic effects and any hematological toxicity were observed under all experimental conditions used [9,[33][34][35]. Notably, these components are found to activate the immune system through enlarging the germinal centers of the white pulp lymph nodules in the spleen [9]. …”

Section: Safety Profilementioning

confidence: 99%

“…Both camel milk and urine are among natural products endowed in agents with such desirable characteristics. These products possess supreme cytotoxic effect against various cancer cells and cell lines (Table 1) [9][10][11]16,23,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51].…”

Section: Cytotoxic Effectmentioning

confidence: 99%