Dose-response in stereotactic irradiation of lung tumors

Wulf, Joern; Baier, Kurt; Mueller, Gerd; Flentje, Michael

doi:10.1016/j.radonc.2005.09.003

Cited by 228 publications

(128 citation statements)

References 28 publications

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“…A sufficiently long ray is traced from the source position through each target voxel and a raysegment intersection check is performed as depicted in Figure 2a. Depending on whether the ray is inside the segment or not and how close it is to the segment edge, the dose to the target voxel is calculated using Equations (4)(5)(6)(7)(8). The distance between the segment edge and ray is calculated at the isocentre plane as shown in Figure 2b.…”

Section: Dose Calculation To a Moving Targetsupporting

confidence: 53%

“…Moreover, hypofractionated treatments have been shown to result in better clinical outcomes for medically inoperable early-stage lung tumours. [4][5][6][7] Better targeting accuracy coupled with superior normal tissue sparing and higher dose conformality, especially with smaller treatment fields used in stereotactic treatments, allows clinicians to prescribe extremely high doses in very few fractions (approximately three). With the advent of image-guided RT, this type of treatment is becoming increasingly common for lung RT.…”

Section: Discussionmentioning

confidence: 99%

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4D radiobiological modelling of the interplay effect in conventionally and hypofractionated lung tumour IMRT

Selvaraj

Uzan²,

Baker³

et al. 2015

BJR

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Objective: To study the impact of the interplay between respiration-induced tumour motion and multileaf collimator leaf movements in intensity-modulated radiotherapy (IMRT) as a function of number of fractions, dose rate on population mean tumour control probability (TCP pop ) using an in-house developed dose model. Methods: Delivered dose was accumulated in a voxel-byvoxel basis inclusive of tumour motion over the course of treatment. The effect of interplay on dose and TCP pop was studied for conventionally and hypofractionated treatments using digital imaging and communications in medicine data sets. Moreover, the effect of dose rate on interplay was also studied for single-fraction treatments. Simulations were repeated several times to obtain TCP pop for each plan. Results: The average variation observed in mean dose to the target volumes were 20.76% 6 0.36% for the 20-fraction treatment and 20.26% 6 0.68% and 21.05% 6 0.98% for the three-and single-fraction treatments, respectively. For the 20-fraction treatment, the drop in TCP pop was 21.05% 6 0.39%, whereas for the three-and single-fraction treatments, it was 22.80% 6 1.68% and 24.00% 6 2.84%, respectively. By reducing the dose rate from 600 to 300 MU min 21 for the single-fraction treatments, the drop in TCP pop was reduced by approximately 1.5%. Conclusion: The effect of interplay on TCP pop is negligible for conventionally fractionated treatments, whereas considerable drop in TCP pop is observed for the three-and single-fraction treatments. Reduced dose rate could be used in hypofractionated treatments to reduce the interplay effect. Advances in knowledge: A novel in silico dose model is presented to determine the impact of interplay effect in IMRT treatments on TCP pop .

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Section: Dose Calculation To a Moving Targetsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

4D radiobiological modelling of the interplay effect in conventionally and hypofractionated lung tumour IMRT

Selvaraj

Uzan²,

Baker³

et al. 2015

BJR

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“…In a recent review of 18 papers published 1988 Á2000, reporting results with conventional RT, the incidence of local failure of stage I tumours was 40% (6.4 Á70%) [10]. Local failure has been reported up to at least 3 years after RT treatment of stage I NSCLC [29,36,37]. This is similar to our finding with SBRT.…”

Section: Discussionmentioning

confidence: 74%

Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries

et al. 2006

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“…Conventional radiotherapy for early‐stage non‐small cell lung cancer (NSCLC) with or without concurrent chemotherapy is associated with the cancer specific survival rate of below 40% at five years 1 , 2 . Dose escalation and hyprofractional dose delivery have demonstrated an improvement in local control and patients’ survival 3 , 4 . However, the substantial breathing‐induced tumor motion limits their applications.…”

Section: Introductionmentioning

confidence: 99%

A design of a DICOM‐RT‐based tool box for nonrigid 4D dose calculation

Wong

Baker

Leung

et al. 2016

J Applied Clin Med Phys

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The study was aimed to introduce a design of a DICOM‐RT‐based tool box to facilitate 4D dose calculation based on deformable voxel‐dose registration. The computational structure and the calculation algorithm of the tool box were explicitly discussed in the study. The tool box was written in MATLAB in conjunction with CERR. It consists of five main functions which allow a) importation of DICOM‐RT‐based 3D dose plan, b) deformable image registration, c) tracking voxel doses along breathing cycle, d) presentation of temporal dose distribution at different time phase, and e) derivation of 4D dose. The efficacy of using the tool box for clinical application had been verified with nine clinical cases on retrospective‐study basis. The logistic and the robustness of the tool box were tested with 27 applications and the results were shown successful with no computational errors encountered. In the study, the accumulated dose coverage as a function of planning CT taken at end‐inhale, end‐exhale, and mean tumor position were assessed. The results indicated that the majority of the cases (67%) achieved maximum target coverage, while the planning CT was taken at the temporal mean tumor position and 56% at the end‐exhale position. The comparable results to the literature imply that the studied tool box can be reliable for 4D dose calculation. The authors suggest that, with proper application, 4D dose calculation using deformable registration can provide better dose evaluation for treatment with moving target.PACS number(s): 87.55.kh

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Dose-response in stereotactic irradiation of lung tumors

Cited by 228 publications

References 28 publications

4D radiobiological modelling of the interplay effect in conventionally and hypofractionated lung tumour IMRT

4D radiobiological modelling of the interplay effect in conventionally and hypofractionated lung tumour IMRT

Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries

A design of a DICOM‐RT‐based tool box for nonrigid 4D dose calculation

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